ENSG00000183337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378444 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding protein_coding 53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 3.718483 1.14893666 6.9923969 0.29180235 0.86113672 2.5950471 0.06892917 0.023833333 0.123966667 0.10013333 1.286476e-05 9.992588e-34 FALSE TRUE
ENST00000378463 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding processed_transcript 53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 3.126172 6.14976033 0.1963240 1.70646605 0.19632396 -4.8998909 0.06127500 0.122266667 0.003500000 -0.11876667 4.904339e-03 9.992588e-34 FALSE TRUE
ENST00000397354 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding protein_coding 53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 6.824244 4.82783514 7.0362251 1.00737378 0.59578281 0.5424890 0.12555000 0.097700000 0.124766667 0.02706667 6.083732e-01 9.992588e-34 FALSE TRUE
ENST00000427012 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding protein_coding 53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 15.114547 10.05216053 14.8979195 2.41024223 0.54606483 0.5671388 0.28027500 0.199800000 0.264166667 0.06436667 4.509013e-01 9.992588e-34 FALSE TRUE
ENST00000672265 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding retained_intron 53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 3.054281 10.15860591 0.2502842 2.02403010 0.05007951 -5.2878904 0.06323333 0.207733333 0.004466667 -0.20326667 2.120812e-17 9.992588e-34 FALSE TRUE
ENST00000673391 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding protein_coding 53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 10.226310 7.99418550 10.8905039 2.03392976 1.17447616 0.4455683 0.19158333 0.162333333 0.193033333 0.03070000 7.650305e-01 9.992588e-34 FALSE TRUE
MSTRG.34103.4 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding   53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 1.304856 0.06530093 3.5473185 0.03422896 0.11097891 5.5619786 0.02306667 0.001266667 0.062900000 0.06163333 9.992588e-34 9.992588e-34 FALSE TRUE
MSTRG.34103.5 ENSG00000183337 HEK293_OSMI2_2hA HEK293_TMG_2hB BCOR protein_coding   53.32154 49.2838 56.39528 3.149319 0.07335606 0.1944238 1.529918 0.04859987 3.0595680 0.03508707 0.53246311 5.7109944 0.02692917 0.001066667 0.054266667 0.05320000 7.516023e-12 9.992588e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183337 E001 0.0000000       X 40049815 40049819 5 -      
ENSG00000183337 E002 1.3660607 0.0410364710 9.952000e-04 3.941416e-03 X 40049820 40049991 172 - 0.000 0.577 14.985
ENSG00000183337 E003 1.6940691 0.0084385131 2.706952e-04 1.260474e-03 X 40051246 40051247 2 - 0.000 0.618 15.200
ENSG00000183337 E004 1.6940691 0.0084385131 2.706952e-04 1.260474e-03 X 40051248 40051250 3 - 0.000 0.618 15.200
ENSG00000183337 E005 4.6015653 0.0037900464 2.362658e-10 3.907109e-09 X 40051251 40051253 3 - 0.000 1.003 16.728
ENSG00000183337 E006 4.6015653 0.0037900464 2.362658e-10 3.907109e-09 X 40051254 40051254 1 - 0.000 1.003 16.728
ENSG00000183337 E007 33.1365337 0.0165292887 2.420272e-19 1.437797e-17 X 40051255 40051271 17 - 0.918 1.774 3.003
ENSG00000183337 E008 50.8757274 0.0006211998 1.431793e-55 1.227370e-52 X 40051272 40051311 40 - 1.017 1.959 3.260
ENSG00000183337 E009 63.7189863 0.0003969644 1.702363e-40 6.096551e-38 X 40051312 40051317 6 - 1.387 2.010 2.116
ENSG00000183337 E010 1348.4554814 0.0021955718 9.838045e-68 1.360429e-64 X 40051318 40052108 791 - 2.904 3.271 1.219
ENSG00000183337 E011 240.7472556 0.0002138490 1.344376e-09 1.945074e-08 X 40052109 40052112 4 - 2.324 2.429 0.352
ENSG00000183337 E012 478.0634858 0.0005819279 7.567741e-16 2.906316e-14 X 40052113 40052218 106 - 2.611 2.733 0.405
ENSG00000183337 E013 632.0086253 0.0004715212 9.104961e-13 2.251250e-11 X 40052219 40052400 182 - 2.752 2.838 0.286
ENSG00000183337 E014 9.9027826 0.0018335943 2.644089e-01 4.023778e-01 X 40053838 40053885 48 - 0.991 1.073 0.299
ENSG00000183337 E015 507.8855716 0.0016010965 1.949506e-03 7.070375e-03 X 40053886 40054042 157 - 2.682 2.724 0.139
ENSG00000183337 E016 336.6878471 0.0001499500 4.895743e-03 1.564054e-02 X 40054256 40054333 78 - 2.516 2.534 0.061
ENSG00000183337 E017 436.9871729 0.0001374334 5.646035e-02 1.205306e-01 X 40055368 40055513 146 - 2.639 2.635 -0.013
ENSG00000183337 E018 5.1119436 0.0253340029 8.203611e-01 8.866820e-01 X 40055514 40056233 720 - 0.811 0.745 -0.263
ENSG00000183337 E019 431.6873502 0.0001766187 2.094291e-02 5.346772e-02 X 40057155 40057321 167 - 2.630 2.634 0.013
ENSG00000183337 E020 583.7475253 0.0005154097 5.953373e-03 1.848508e-02 X 40062139 40062393 255 - 2.756 2.769 0.044
ENSG00000183337 E021 667.6788680 0.0008177234 4.968909e-01 6.334672e-01 X 40062746 40063071 326 - 2.833 2.811 -0.073
ENSG00000183337 E022 545.2202947 0.0002333922 1.426315e-01 2.516237e-01 X 40063608 40063850 243 - 2.763 2.702 -0.203
ENSG00000183337 E023 101.4517298 0.0054799191 2.312614e-01 3.639911e-01 X 40063851 40063952 102 - 2.049 1.957 -0.311
ENSG00000183337 E024 581.8381273 0.0001428275 3.688800e-02 8.525567e-02 X 40064336 40064599 264 - 2.795 2.726 -0.230
ENSG00000183337 E025 1.9563176 0.0081518630 8.535101e-01 9.093486e-01 X 40067992 40068120 129 - 0.495 0.439 -0.282
ENSG00000183337 E026 456.6950038 0.0001164731 6.608664e-03 2.020873e-02 X 40070973 40071159 187 - 2.697 2.614 -0.278
ENSG00000183337 E027 152.0249868 0.0003190700 2.806636e-04 1.301071e-03 X 40071637 40071690 54 - 2.252 2.106 -0.485
ENSG00000183337 E028 5.7858363 0.0515794278 5.922217e-02 1.253061e-01 X 40071906 40072348 443 - 0.964 0.621 -1.368
ENSG00000183337 E029 2777.6972552 0.0036202961 5.268786e-22 4.202761e-20 X 40072349 40075180 2832 - 3.557 3.299 -0.857
ENSG00000183337 E030 212.6838444 0.0118219431 6.123934e-12 1.319564e-10 X 40076454 40076532 79 - 2.499 2.062 -1.463
ENSG00000183337 E031 214.1027986 0.0025162100 1.729100e-27 2.349876e-25 X 40077844 40077969 126 - 2.498 2.075 -1.413
ENSG00000183337 E032 1.7800150 0.0080338142 3.718326e-04 1.665426e-03 X 40095796 40096192 397 - 0.667 0.000 -15.483
ENSG00000183337 E033 1.0812319 0.1740750025 5.069618e-01 6.425917e-01 X 40096460 40096612 153 - 0.402 0.229 -1.135
ENSG00000183337 E034 154.1897522 0.0116326458 9.227951e-11 1.638433e-09 X 40097215 40097930 716 - 2.358 1.929 -1.434
ENSG00000183337 E035 28.1234833 0.0104349911 5.531226e-10 8.601118e-09 X 40097931 40097979 49 - 1.671 1.086 -2.035
ENSG00000183337 E036 3.9524817 0.0038731739 1.853456e-03 6.768936e-03 X 40098176 40098456 281 - 0.885 0.380 -2.257
ENSG00000183337 E037 0.9202533 0.0538037933 1.706426e-01 2.889940e-01 X 40098765 40098837 73 - 0.401 0.130 -2.118
ENSG00000183337 E038 4.2480464 0.0153243126 4.666227e-01 6.061663e-01 X 40098972 40099167 196 - 0.790 0.652 -0.566
ENSG00000183337 E039 5.3446503 0.0041888319 7.771754e-01 8.565890e-01 X 40144652 40144663 12 - 0.789 0.795 0.023
ENSG00000183337 E040 23.3082290 0.0008116024 2.119626e-01 3.408223e-01 X 40144664 40144906 243 - 1.359 1.411 0.182
ENSG00000183337 E041 9.9762625 0.0132725477 3.232998e-03 1.095263e-02 X 40146445 40146467 23 - 1.200 0.817 -1.417
ENSG00000183337 E042 21.8428830 0.0236144741 4.702252e-02 1.038656e-01 X 40146468 40146629 162 - 1.470 1.228 -0.845
ENSG00000183337 E043 1.9315304 0.0076044139 2.023339e-04 9.738955e-04 X 40177007 40177329 323 - 0.694 0.000 -15.599