ENSG00000183291

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331835 ENSG00000183291 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOF protein_coding protein_coding 188.7142 68.71155 320.7921 9.302 7.412058 2.222849 40.14755 22.689213 66.41005 2.062446 2.586566 1.548977 0.2299708 0.3338667 0.2072333 -0.12663333 6.077481e-06 4.688672e-09   FALSE
ENST00000370554 ENSG00000183291 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOF protein_coding protein_coding 188.7142 68.71155 320.7921 9.302 7.412058 2.222849 71.02500 25.628245 115.67268 4.073750 4.413136 2.173803 0.3767125 0.3710000 0.3603667 -0.01063333 8.713214e-01 4.688672e-09   FALSE
ENST00000469566 ENSG00000183291 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOF protein_coding processed_transcript 188.7142 68.71155 320.7921 9.302 7.412058 2.222849 59.59568 9.852008 108.39679 5.006997 10.279701 3.458430 0.2829167 0.1381000 0.3374000 0.19930000 6.162844e-01 4.688672e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183291 E001 15.5584382 6.425731e-03 1.121008e-28 1.680155e-26 1 86858684 86858788 105 - 0.592 1.669 3.970
ENSG00000183291 E002 56.8981910 4.508552e-04 2.889106e-17 1.328477e-15 1 86862445 86862724 280 - 1.564 1.980 1.406
ENSG00000183291 E003 403.5252830 1.782708e-04 2.691679e-19 1.587085e-17 1 86862725 86862826 102 - 2.496 2.682 0.620
ENSG00000183291 E004 1757.5446259 9.512077e-04 9.991687e-11 1.762636e-09 1 86862827 86863166 340 - 3.156 3.261 0.349
ENSG00000183291 E005 1419.7448295 1.484910e-03 1.731674e-01 2.923082e-01 1 86863167 86863300 134 - 3.084 3.114 0.101
ENSG00000183291 E006 1855.3942520 1.125099e-04 9.445933e-01 9.692269e-01 1 86863301 86863516 216 - 3.208 3.215 0.026
ENSG00000183291 E007 1313.3303184 8.142307e-05 6.621136e-04 2.760038e-03 1 86863517 86863605 89 - 3.067 3.035 -0.109
ENSG00000183291 E008 0.2924217 2.749024e-02 1.000000e+00   1 86866072 86866169 98 - 0.128 0.000 -8.417
ENSG00000183291 E009 3.4999987 4.756770e-03 5.868188e-01 7.102856e-01 1 86866806 86866847 42 - 0.629 0.541 -0.397
ENSG00000183291 E010 873.0548241 1.532229e-04 1.376155e-04 6.930786e-04 1 86868053 86868095 43 - 2.894 2.844 -0.168
ENSG00000183291 E011 617.9720299 6.423226e-04 3.535826e-02 8.233991e-02 1 86868096 86868102 7 - 2.742 2.703 -0.128
ENSG00000183291 E012 1171.4269965 8.279883e-05 1.201360e-06 9.809666e-06 1 86880662 86880725 64 - 3.023 2.969 -0.178
ENSG00000183291 E013 21.5944241 1.058323e-03 7.562411e-01 8.413550e-01 1 86887156 86887196 41 - 1.298 1.277 -0.072
ENSG00000183291 E014 1528.3404580 8.655531e-04 2.049787e-06 1.590783e-05 1 86903281 86903448 168 - 3.142 3.065 -0.256
ENSG00000183291 E015 6.3393845 4.324086e-03 7.223577e-01 8.164795e-01 1 86913806 86914027 222 - 0.800 0.856 0.218
ENSG00000183291 E016 769.2637812 1.476615e-03 9.968450e-04 3.947106e-03 1 86914028 86914297 270 - 2.844 2.768 -0.251
ENSG00000183291 E017 37.4239014 4.175635e-03 1.528466e-02 4.113348e-02 1 86914298 86914314 17 - 1.479 1.656 0.605
ENSG00000183291 E018 46.3337402 2.850974e-03 4.973006e-01 6.338402e-01 1 86914315 86914424 110 - 1.606 1.657 0.172