ENSG00000183250

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330551 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA lncRNA 7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 0.61901031 1.0881369 0.0000000 0.25521697 0.00000000 -6.7789142 0.07120417 0.09373333 0.00000000 -0.093733333 1.067036e-09 1.067036e-09 FALSE TRUE
ENST00000397841 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA lncRNA 7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 3.44844841 4.7777430 2.2319302 0.71902803 0.25822075 -1.0946044 0.45958333 0.41556667 0.41933333 0.003766667 1.000000e+00 1.067036e-09 FALSE TRUE
ENST00000654166 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA lncRNA 7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 0.52746041 1.3088607 0.9446710 0.14703579 0.12472513 -0.4662166 0.07485000 0.11463333 0.17750000 0.062866667 1.596827e-01 1.067036e-09 FALSE TRUE
ENST00000660377 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA lncRNA 7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 0.84427390 2.4537021 0.8259736 0.05657917 0.20632894 -1.5592986 0.09358750 0.22013333 0.15440000 -0.065733333 5.460293e-01 1.067036e-09 FALSE TRUE
ENST00000663249 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA lncRNA 7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 0.43113530 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.06157917 0.00000000 0.00000000 0.000000000   1.067036e-09 FALSE TRUE
ENST00000667826 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA lncRNA 7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 0.96833336 0.9604101 0.8372017 0.14195152 0.08593859 -0.1958891 0.15068750 0.08326667 0.15713333 0.073866667 1.955252e-02 1.067036e-09 FALSE TRUE
MSTRG.21476.9 ENSG00000183250 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01547 lncRNA   7.573523 11.47201 5.331014 1.411974 0.06991061 -1.10419 0.05749748 0.0000000 0.3895710 0.00000000 0.20475942 5.3203798 0.01244167 0.00000000 0.07226667 0.072266667 1.041340e-01 1.067036e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183250 E001 51.251199 0.0004708100 7.438624e-01 8.323735e-01 21 44932814 44933306 493 - 1.651 1.669 0.062
ENSG00000183250 E002 17.469849 0.0105819982 2.804988e-01 4.203554e-01 21 44933307 44933314 8 - 1.295 1.191 -0.367
ENSG00000183250 E003 183.645268 0.0025395409 3.571407e-01 5.015559e-01 21 44933315 44934073 759 - 2.191 2.225 0.114
ENSG00000183250 E004 68.599320 0.0004594353 5.122679e-01 6.471783e-01 21 44934074 44934228 155 - 1.806 1.778 -0.096
ENSG00000183250 E005 64.026645 0.0028231857 5.137180e-01 6.484923e-01 21 44934229 44934368 140 - 1.779 1.750 -0.099
ENSG00000183250 E006 31.937938 0.0012060567 2.052805e-01 3.327752e-01 21 44934369 44934724 356 - 1.521 1.439 -0.282
ENSG00000183250 E007 8.529791 0.0033878222 6.305304e-01 7.457134e-01 21 44934725 44934729 5 - 0.962 0.907 -0.210
ENSG00000183250 E008 37.886683 0.0007061757 8.161750e-02 1.620893e-01 21 44934730 44934933 204 - 1.453 1.565 0.383
ENSG00000183250 E009 68.793104 0.0007159030 4.408234e-01 5.824818e-01 21 44934934 44935004 71 - 1.765 1.802 0.126
ENSG00000183250 E010 74.907501 0.0003752830 2.334317e-01 3.664723e-01 21 44935005 44935093 89 - 1.786 1.840 0.182
ENSG00000183250 E011 41.727243 0.0005483495 2.008682e-01 3.272720e-01 21 44935094 44935096 3 - 1.515 1.593 0.267
ENSG00000183250 E012 121.835767 0.0006350252 7.698149e-02 1.546626e-01 21 44935627 44935890 264 - 1.987 2.051 0.214
ENSG00000183250 E013 17.603378 0.0126851706 1.350940e-01 2.412232e-01 21 44937539 44937682 144 - 1.306 1.165 -0.495
ENSG00000183250 E014 24.660222 0.0008212120 9.701728e-02 1.859195e-01 21 44937683 44938443 761 - 1.438 1.319 -0.413
ENSG00000183250 E015 22.123363 0.0009361834 6.782040e-01 7.827356e-01 21 44938444 44938607 164 - 1.285 1.319 0.120
ENSG00000183250 E016 20.911999 0.0009998888 9.498814e-01 9.726566e-01 21 44938608 44938760 153 - 1.285 1.281 -0.014
ENSG00000183250 E017 16.941069 0.0011257653 2.979033e-01 4.392898e-01 21 44938761 44938835 75 - 1.262 1.173 -0.317
ENSG00000183250 E018 28.087295 0.0007542791 1.921908e-03 6.983520e-03 21 44938836 44939050 215 - 1.551 1.346 -0.709
ENSG00000183250 E019 39.587981 0.0005312772 6.927909e-07 5.954142e-06 21 44939051 44939592 542 - 1.735 1.459 -0.941
ENSG00000183250 E020 75.670345 0.0004199468 1.868563e-01 3.097870e-01 21 44939593 44939769 177 - 1.786 1.845 0.201
ENSG00000183250 E021 46.143402 0.0097080608 1.852008e-01 3.077373e-01 21 44939770 44939941 172 - 1.540 1.643 0.353