ENSG00000183049

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378845 ENSG00000183049 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMK1D protein_coding protein_coding 1.479414 1.987633 2.049519 0.1515824 0.1533385 0.04401636 0.4792048 0.6394233 0.6141940 0.09094622 0.17804458 -0.05716471 0.3224542 0.3193667 0.29083333 -0.02853333 0.9048069524 0.0005136528 FALSE TRUE
ENST00000619168 ENSG00000183049 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMK1D protein_coding protein_coding 1.479414 1.987633 2.049519 0.1515824 0.1533385 0.04401636 0.6365150 0.6301312 1.3134625 0.11497513 0.02686752 1.04787771 0.4115917 0.3116333 0.64630000 0.33466667 0.0005136528 0.0005136528 FALSE TRUE
MSTRG.3534.3 ENSG00000183049 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMK1D protein_coding   1.479414 1.987633 2.049519 0.1515824 0.1533385 0.04401636 0.3636941 0.7180781 0.1218628 0.07676422 0.07205921 -2.46505509 0.2659583 0.3690000 0.06286667 -0.30613333 0.0260195338 0.0005136528 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183049 E001 1.998248 0.0100886360 0.461001550 0.60097825 10 12349547 12349651 105 + 0.531 0.407 -0.625
ENSG00000183049 E002 2.664678 0.0059867137 0.015874737 0.04245731 10 12349652 12349732 81 + 0.736 0.350 -1.841
ENSG00000183049 E003 9.599848 0.0018558554 0.002029993 0.00731982 10 12349733 12349910 178 + 1.176 0.857 -1.177
ENSG00000183049 E004 15.124805 0.0012538676 0.104108874 0.19676098 10 12553225 12553356 132 + 1.281 1.146 -0.477
ENSG00000183049 E005 14.396904 0.0247731421 0.559919521 0.68799503 10 12666736 12666810 75 + 1.224 1.168 -0.196
ENSG00000183049 E006 0.000000       10 12666811 12666949 139 +      
ENSG00000183049 E007 24.589450 0.0008625701 0.885529213 0.93077921 10 12760948 12761086 139 + 1.414 1.406 -0.028
ENSG00000183049 E008 22.450125 0.0009790789 0.218284205 0.34834131 10 12769673 12769799 127 + 1.311 1.401 0.312
ENSG00000183049 E009 18.828603 0.0487611878 0.578633395 0.70369365 10 12791158 12791233 76 + 1.240 1.325 0.299
ENSG00000183049 E010 22.135443 0.0039187304 0.552150819 0.68146692 10 12814195 12814307 113 + 1.332 1.379 0.163
ENSG00000183049 E011 18.354604 0.0011039603 0.368782968 0.51319876 10 12816250 12816328 79 + 1.241 1.312 0.251
ENSG00000183049 E012 22.987025 0.0008973076 0.991997730 0.99910151 10 12824465 12824552 88 + 1.378 1.379 0.002
ENSG00000183049 E013 22.227953 0.0009006728 0.921311291 0.95432793 10 12825573 12825690 118 + 1.359 1.368 0.029
ENSG00000183049 E014 4.338382 0.0039143306 0.086860755 0.17037024 10 12825691 12825694 4 + 0.572 0.818 1.028
ENSG00000183049 E015 5.443333 0.0073170215 0.211661321 0.34044474 10 12825695 12826143 449 + 0.708 0.875 0.665
ENSG00000183049 E016 248.493286 0.0017030132 0.937104069 0.96446800 10 12828769 12835545 6777 + 2.392 2.394 0.006