ENSG00000183023

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402441 ENSG00000183023 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC8A1 protein_coding protein_coding 0.4637271 0.2033855 0.8055248 0.06165099 0.06098307 1.934267 0.02235939 0.07045728 0.00000000 0.070457282 0.00000000 -3.0082230 0.05332917 0.2365333 0.00000000 -0.2365333 4.422851e-01 5.812019e-06 FALSE TRUE
ENST00000406391 ENSG00000183023 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC8A1 protein_coding protein_coding 0.4637271 0.2033855 0.8055248 0.06165099 0.06098307 1.934267 0.17811287 0.00000000 0.54454925 0.000000000 0.04313277 5.7932437 0.26851250 0.0000000 0.67676667 0.6767667 5.812019e-06 5.812019e-06 FALSE TRUE
ENST00000406785 ENSG00000183023 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC8A1 protein_coding protein_coding 0.4637271 0.2033855 0.8055248 0.06165099 0.06098307 1.934267 0.06959739 0.07767195 0.06711572 0.004426675 0.03544566 -0.1850904 0.23415417 0.4858000 0.08963333 -0.3961667 1.369631e-01 5.812019e-06 FALSE TRUE
ENST00000407929 ENSG00000183023 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC8A1 protein_coding nonsense_mediated_decay 0.4637271 0.2033855 0.8055248 0.06165099 0.06098307 1.934267 0.08959850 0.05069154 0.09858557 0.050691535 0.05348570 0.8392651 0.22200833 0.2255333 0.12466667 -0.1008667 9.900977e-01 5.812019e-06 TRUE TRUE
ENST00000408028 ENSG00000183023 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC8A1 protein_coding protein_coding 0.4637271 0.2033855 0.8055248 0.06165099 0.06098307 1.934267 0.06614903 0.00000000 0.00000000 0.000000000 0.00000000 0.0000000 0.11198333 0.0000000 0.00000000 0.0000000   5.812019e-06 FALSE TRUE
ENST00000417271 ENSG00000183023 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC8A1 protein_coding protein_coding 0.4637271 0.2033855 0.8055248 0.06165099 0.06098307 1.934267 0.01873063 0.00000000 0.03220276 0.000000000 0.03220276 2.0773372 0.05595417 0.0000000 0.03480000 0.0348000 1.000000e+00 5.812019e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183023 E001 41.4477272 0.017004755 3.148645e-05 0.0001863834 2 40097270 40114730 17461 - 1.492 1.764 0.927
ENSG00000183023 E002 6.2501429 0.009953011 8.233850e-01 0.8887131662 2 40114731 40115030 300 - 0.813 0.875 0.238
ENSG00000183023 E003 2.6530217 0.006230623 8.427366e-01 0.9020148149 2 40115031 40115044 14 - 0.518 0.577 0.275
ENSG00000183023 E004 2.8681242 0.009339825 6.063138e-01 0.7264994856 2 40115045 40115112 68 - 0.518 0.627 0.499
ENSG00000183023 E005 1.7318380 0.019292199 7.476713e-01 0.8351114078 2 40115113 40115249 137 - 0.376 0.456 0.432
ENSG00000183023 E006 0.7697675 0.029678004 1.089758e-01 0.2040234961 2 40115250 40115252 3 - 0.090 0.379 2.602
ENSG00000183023 E007 5.2183971 0.037675674 3.948145e-01 0.5386424385 2 40115253 40115629 377 - 0.813 0.713 -0.402
ENSG00000183023 E008 5.8584348 0.055434749 3.411635e-01 0.4850717143 2 40139401 40139676 276 - 0.857 0.753 -0.411
ENSG00000183023 E009 3.1710820 0.271023449 4.929734e-01 0.6300544228 2 40160765 40160864 100 - 0.625 0.580 -0.200
ENSG00000183023 E010 3.6923358 0.045245446 9.299337e-01 0.9599042178 2 40164854 40164984 131 - 0.648 0.673 0.107
ENSG00000183023 E011 0.1515154 0.042744864 8.754721e-01   2 40170281 40170349 69 - 0.090 0.000 -8.320
ENSG00000183023 E012 0.0000000       2 40174706 40174720 15 -      
ENSG00000183023 E013 2.7377409 0.012914310 9.944521e-01 1.0000000000 2 40174825 40174842 18 - 0.547 0.577 0.136
ENSG00000183023 E014 0.0000000       2 40175261 40175281 21 -      
ENSG00000183023 E015 4.4955054 0.003747950 1.981269e-01 0.3238668805 2 40177752 40177855 104 - 0.781 0.627 -0.642
ENSG00000183023 E016 0.0000000       2 40178387 40178493 107 -      
ENSG00000183023 E017 21.9525343 0.001011270 4.718808e-04 0.0020525889 2 40428473 40430019 1547 - 1.415 1.198 -0.758
ENSG00000183023 E018 1.8133244 0.007847889 1.560441e-01 0.2698502077 2 40430020 40430060 41 - 0.518 0.284 -1.312
ENSG00000183023 E019 2.5969378 0.009279596 1.148165e-01 0.2125617981 2 40430061 40430271 211 - 0.624 0.378 -1.213
ENSG00000183023 E020 0.7708142 0.015520147 4.636208e-01 0.6033921498 2 40430272 40430280 9 - 0.283 0.165 -0.989
ENSG00000183023 E021 1.0738451 0.012198908 2.181174e-01 0.3481480228 2 40430281 40430301 21 - 0.376 0.165 -1.575
ENSG00000183023 E022 0.5891098 0.018497784 1.284520e-01 0.2320056417 2 40430302 40430304 3 - 0.283 0.000 -10.161
ENSG00000183023 E023 0.4449813 0.021574696 1.000000e+00 1.0000000000 2 40446415 40446648 234 - 0.164 0.165 0.008
ENSG00000183023 E024 1.1919493 0.012211961 1.495254e-01 0.2610171204 2 40451904 40452008 105 - 0.416 0.165 -1.799
ENSG00000183023 E025 0.5964967 0.019936565 6.733377e-01 0.7790509656 2 40452009 40452069 61 - 0.227 0.165 -0.577
ENSG00000183023 E026 0.2934659 0.030175101 6.524158e-01   2 40452070 40452090 21 - 0.090 0.165 1.008
ENSG00000183023 E027 0.0000000       2 40453161 40453349 189 -      
ENSG00000183023 E028 0.0000000       2 40453350 40453438 89 -      
ENSG00000183023 E029 0.0000000       2 40512349 40512361 13 -      
ENSG00000183023 E030 0.0000000       2 40512362 40512435 74 -      
ENSG00000183023 E031 0.0000000       2 40610930 40611053 124 -