ENSG00000183020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332231 ENSG00000183020 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A2 protein_coding protein_coding 53.21053 78.10955 34.80032 1.179489 1.528647 -1.166169 4.3313065 5.946148 2.790986 2.23820266 0.9113412 -1.0884448 0.07520000 0.07530000 0.07983333 0.004533333 0.991336752 2.239765e-05 FALSE TRUE
ENST00000448903 ENSG00000183020 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A2 protein_coding protein_coding 53.21053 78.10955 34.80032 1.179489 1.528647 -1.166169 18.5461001 35.427220 9.546244 0.09271368 0.6077685 -1.8907498 0.32485833 0.45373333 0.27636667 -0.177366667 0.000153907 2.239765e-05 FALSE TRUE
ENST00000528815 ENSG00000183020 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A2 protein_coding nonsense_mediated_decay 53.21053 78.10955 34.80032 1.179489 1.528647 -1.166169 2.9565954 5.554166 1.920871 1.84776895 0.9266756 -1.5269135 0.05851667 0.07183333 0.05576667 -0.016066667 0.843604170 2.239765e-05 TRUE TRUE
ENST00000529438 ENSG00000183020 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A2 protein_coding processed_transcript 53.21053 78.10955 34.80032 1.179489 1.528647 -1.166169 11.0816346 21.182737 4.766157 1.77470673 1.4461594 -2.1496476 0.18980417 0.27193333 0.13433333 -0.137600000 0.104315421 2.239765e-05 FALSE FALSE
ENST00000534485 ENSG00000183020 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A2 protein_coding protein_coding 53.21053 78.10955 34.80032 1.179489 1.528647 -1.166169 0.5183198 0.000000 2.114318 0.00000000 1.0803099 7.7308561 0.01445000 0.00000000 0.06026667 0.060266667 0.117045751 2.239765e-05 FALSE FALSE
MSTRG.4936.14 ENSG00000183020 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A2 protein_coding   53.21053 78.10955 34.80032 1.179489 1.528647 -1.166169 8.7113806 5.424444 8.954111 2.53796148 1.1455400 0.7220281 0.19310000 0.06850000 0.25753333 0.189033333 0.010714305 2.239765e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183020 E001 0.0000000       11 924881 924937 57 +      
ENSG00000183020 E002 2.6778234 0.0059769759 3.194943e-01 4.625732e-01 11 925809 925869 61 + 0.633 0.467 -0.770
ENSG00000183020 E003 3.4141928 0.0082040354 3.857239e-01 5.299074e-01 11 925870 925871 2 + 0.685 0.546 -0.613
ENSG00000183020 E004 6.5392642 0.0206533133 6.955476e-03 2.110844e-02 11 925872 925879 8 + 1.058 0.689 -1.424
ENSG00000183020 E005 7.3831418 0.0447278545 1.451264e-02 3.939215e-02 11 925880 925880 1 + 1.097 0.740 -1.358
ENSG00000183020 E006 48.1692935 0.0240703015 4.920948e-04 2.130147e-03 11 925881 925899 19 + 1.832 1.522 -1.052
ENSG00000183020 E007 84.8701595 0.0313181063 5.975349e-03 1.854298e-02 11 925900 925944 45 + 2.037 1.784 -0.853
ENSG00000183020 E008 120.4783205 0.0301198658 1.308237e-03 5.004375e-03 11 925945 926000 56 + 2.207 1.925 -0.947
ENSG00000183020 E009 180.0086988 0.0203132182 2.732580e-03 9.470547e-03 11 926001 926088 88 + 2.341 2.118 -0.743
ENSG00000183020 E010 0.0000000       11 932687 932777 91 +      
ENSG00000183020 E011 0.0000000       11 933555 933597 43 +      
ENSG00000183020 E012 0.0000000       11 940735 940894 160 +      
ENSG00000183020 E013 0.0000000       11 942279 942394 116 +      
ENSG00000183020 E014 0.4428904 0.5110180070 8.183847e-01 8.852096e-01 11 943100 943314 215 + 0.000 0.149 8.790
ENSG00000183020 E015 5.8626844 0.0028316574 5.652867e-05 3.142552e-04 11 946461 946963 503 + 1.098 0.591 -1.992
ENSG00000183020 E016 1.4371390 0.0091320969 2.372348e-01 3.709795e-01 11 956786 956982 197 + 0.504 0.293 -1.187
ENSG00000183020 E017 225.9475834 0.0054640864 2.507825e-04 1.178557e-03 11 959437 959505 69 + 2.394 2.235 -0.533
ENSG00000183020 E018 352.3629155 0.0042245343 5.818302e-05 3.225246e-04 11 970169 970311 143 + 2.579 2.431 -0.494
ENSG00000183020 E019 393.3331349 0.0019929278 5.583790e-05 3.108346e-04 11 972062 972217 156 + 2.604 2.488 -0.385
ENSG00000183020 E020 216.5333835 0.0043997611 1.517975e-01 2.641118e-01 11 972218 972255 38 + 2.305 2.246 -0.197
ENSG00000183020 E021 370.1958086 0.0023771834 1.260575e-02 3.498258e-02 11 977095 977224 130 + 2.550 2.474 -0.255
ENSG00000183020 E022 323.6595185 0.0019621986 7.681635e-03 2.298013e-02 11 981198 981299 102 + 2.495 2.414 -0.270
ENSG00000183020 E023 2.3572891 0.0065448966 4.281541e-01 5.709504e-01 11 984191 984644 454 + 0.573 0.437 -0.659
ENSG00000183020 E024 357.6365677 0.0001463307 1.321313e-02 3.640843e-02 11 984645 984753 109 + 2.517 2.464 -0.176
ENSG00000183020 E025 0.2214452 0.0413623914 1.000000e+00   11 985384 985431 48 + 0.000 0.077 8.772
ENSG00000183020 E026 51.8148949 0.0004316472 9.718731e-01 9.864324e-01 11 985432 985434 3 + 1.647 1.646 -0.004
ENSG00000183020 E027 405.9495435 0.0001394172 3.453516e-02 8.077861e-02 11 985435 985537 103 + 2.564 2.522 -0.141
ENSG00000183020 E028 310.0558816 0.0010938879 1.730714e-01 2.921842e-01 11 985538 985582 45 + 2.443 2.406 -0.123
ENSG00000183020 E029 517.5975359 0.0002684272 1.206475e-01 2.208872e-01 11 986785 986953 169 + 2.658 2.629 -0.097
ENSG00000183020 E030 0.1817044 0.0400654388 1.000000e+00   11 986954 987097 144 + 0.000 0.077 8.779
ENSG00000183020 E031 495.3104596 0.0002045925 9.279730e-06 6.214929e-05 11 988552 988689 138 + 2.679 2.597 -0.274
ENSG00000183020 E032 2.5713448 0.0069068579 2.911041e-01 4.319399e-01 11 988690 988827 138 + 0.322 0.521 1.080
ENSG00000183020 E033 6.5645203 0.0024701028 1.924957e-02 4.987822e-02 11 991993 992502 510 + 1.014 0.720 -1.135
ENSG00000183020 E034 617.7587737 0.0007029816 1.193160e-02 3.336785e-02 11 992503 992685 183 + 2.752 2.702 -0.164
ENSG00000183020 E035 453.6871123 0.0002541111 6.934307e-01 7.944626e-01 11 993284 993381 98 + 2.587 2.580 -0.023
ENSG00000183020 E036 414.0561298 0.0002652051 2.152040e-02 5.468486e-02 11 993754 993862 109 + 2.502 2.553 0.170
ENSG00000183020 E037 396.2272349 0.0001556996 6.943943e-03 2.107783e-02 11 993863 993985 123 + 2.474 2.533 0.197
ENSG00000183020 E038 304.7900544 0.0002278140 4.519843e-01 5.928860e-01 11 994072 994245 174 + 2.391 2.411 0.064
ENSG00000183020 E039 0.7717446 0.2616639684 2.233413e-01 3.543806e-01 11 996064 996101 38 + 0.422 0.141 -2.106
ENSG00000183020 E040 1.6511217 0.1823367628 7.555589e-01 8.408528e-01 11 996102 996225 124 + 0.423 0.369 -0.297
ENSG00000183020 E041 155.8260847 0.0014062600 3.347327e-01 4.784635e-01 11 1000432 1000562 131 + 2.085 2.122 0.123
ENSG00000183020 E042 139.2830092 0.0017901740 1.506553e-01 2.625660e-01 11 1000563 1000598 36 + 2.020 2.079 0.199
ENSG00000183020 E043 3.9020354 0.0041850123 3.578846e-01 5.023088e-01 11 1000599 1000684 86 + 0.732 0.591 -0.600
ENSG00000183020 E044 2.4962208 0.0082036761 2.766490e-02 6.734554e-02 11 1001326 1001444 119 + 0.732 0.372 -1.698
ENSG00000183020 E045 10.3972613 0.0310462150 8.673686e-06 5.844996e-05 11 1001646 1002767 1122 + 1.340 0.770 -2.096
ENSG00000183020 E046 5.0301821 0.0314513554 4.194378e-02 9.462591e-02 11 1002768 1003236 469 + 0.939 0.630 -1.236
ENSG00000183020 E047 5.8864801 0.0116009878 2.391881e-02 5.963711e-02 11 1003237 1003721 485 + 0.990 0.686 -1.187
ENSG00000183020 E048 141.8771807 0.0010288974 2.951420e-01 4.362639e-01 11 1003722 1003731 10 + 2.044 2.085 0.137
ENSG00000183020 E049 287.2582532 0.0020985338 9.594030e-02 1.842956e-01 11 1003732 1003804 73 + 2.336 2.392 0.189
ENSG00000183020 E050 14.8046425 0.0011982604 1.231345e-18 6.720677e-17 11 1004785 1005287 503 + 1.571 0.806 -2.744
ENSG00000183020 E051 20.0631511 0.0009443505 1.875240e-17 8.872594e-16 11 1005288 1006274 987 + 1.647 1.003 -2.257
ENSG00000183020 E052 6.9771015 0.0023263103 2.491305e-07 2.344262e-06 11 1006275 1006464 190 + 1.214 0.611 -2.315
ENSG00000183020 E053 6.6822107 0.0916354775 4.744881e-02 1.046344e-01 11 1006465 1006527 63 + 1.079 0.712 -1.403
ENSG00000183020 E054 250.6161262 0.0034717182 4.994531e-01 6.357753e-01 11 1006528 1006543 16 + 2.300 2.327 0.091
ENSG00000183020 E055 415.9627526 0.0021875938 1.143237e-02 3.219271e-02 11 1006544 1006617 74 + 2.479 2.558 0.262
ENSG00000183020 E056 23.4541860 0.0041715268 1.034310e-11 2.148071e-10 11 1006618 1006988 371 + 1.647 1.126 -1.809
ENSG00000183020 E057 46.2113973 0.0007136337 4.703543e-13 1.216015e-11 11 1006989 1008011 1023 + 1.859 1.471 -1.320
ENSG00000183020 E058 284.6152736 0.0012353142 5.083939e-04 2.191239e-03 11 1008012 1008013 2 + 2.293 2.400 0.357
ENSG00000183020 E059 417.6585754 0.0006438128 1.059265e-04 5.492517e-04 11 1008014 1008080 67 + 2.470 2.564 0.313
ENSG00000183020 E060 368.1896039 0.0006148961 7.279392e-04 2.999339e-03 11 1008081 1008135 55 + 2.422 2.507 0.284
ENSG00000183020 E061 30.5366395 0.0250976856 2.044685e-03 7.364528e-03 11 1008136 1009027 892 + 1.636 1.341 -1.014
ENSG00000183020 E062 10.8350424 0.0038164970 9.696829e-01 9.850261e-01 11 1009028 1009099 72 + 0.990 0.995 0.018
ENSG00000183020 E063 588.4645841 0.0010238732 3.747557e-05 2.175333e-04 11 1009100 1009216 117 + 2.617 2.714 0.323
ENSG00000183020 E064 2.5840317 0.0065180997 9.526287e-01 9.743323e-01 11 1009284 1009327 44 + 0.504 0.495 -0.048
ENSG00000183020 E065 380.3291089 0.0012517432 1.442092e-03 5.446789e-03 11 1009328 1009334 7 + 2.434 2.524 0.300
ENSG00000183020 E066 537.6379658 0.0023863535 1.187534e-02 3.323210e-02 11 1009335 1009397 63 + 2.594 2.671 0.256
ENSG00000183020 E067 1.7306895 0.1250138221 3.213071e-01 4.645374e-01 11 1009654 1009682 29 + 0.190 0.412 1.530
ENSG00000183020 E068 624.9746156 0.0019761258 1.577468e-04 7.816458e-04 11 1009683 1009799 117 + 2.636 2.741 0.350
ENSG00000183020 E069 419.5470351 0.0029789740 9.336237e-03 2.712431e-02 11 1009800 1009817 18 + 2.476 2.566 0.301
ENSG00000183020 E070 13.2731629 0.0156747493 2.013582e-01 3.278729e-01 11 1009818 1010547 730 + 1.184 1.038 -0.527
ENSG00000183020 E071 1230.5913481 0.0015763374 4.061152e-14 1.220646e-12 11 1010548 1012245 1698 + 2.877 3.045 0.559