ENSG00000182934

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332118 ENSG00000182934 HEK293_OSMI2_2hA HEK293_TMG_2hB SRPRA protein_coding protein_coding 89.37661 93.47961 90.1134 4.436305 1.545858 -0.05290422 80.97275 90.19586 78.91415 4.595041 0.897961 -0.1927544 0.9042667 0.9645333 0.8759333 -0.0886 9.227559e-12 9.227559e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182934 E001 1091.890421 0.0065554116 1.969987e-06 1.534573e-05 11 126262938 126263322 385 - 2.896 3.105 0.695
ENSG00000182934 E002 912.609603 0.0015025031 1.762397e-15 6.451805e-14 11 126263323 126263473 151 - 2.829 3.022 0.645
ENSG00000182934 E003 1561.258899 0.0014921914 4.782088e-05 2.707244e-04 11 126263474 126263840 367 - 3.125 3.224 0.330
ENSG00000182934 E004 1109.183750 0.0001878950 8.568463e-01 9.115323e-01 11 126263841 126264044 204 - 3.025 3.048 0.075
ENSG00000182934 E005 28.566570 0.0157223622 4.508202e-05 2.567846e-04 11 126264045 126264190 146 - 1.633 1.287 -1.189
ENSG00000182934 E006 651.091804 0.0001245396 6.388078e-01 7.523793e-01 11 126264191 126264289 99 - 2.800 2.814 0.046
ENSG00000182934 E007 824.484136 0.0004169024 7.762650e-01 8.559425e-01 11 126264376 126264539 164 - 2.896 2.921 0.083
ENSG00000182934 E008 16.156015 0.0419912001 2.134993e-04 1.021900e-03 11 126264540 126264755 216 - 1.446 0.987 -1.627
ENSG00000182934 E009 439.298202 0.0015550386 5.384815e-01 6.699044e-01 11 126264959 126265020 62 - 2.615 2.650 0.115
ENSG00000182934 E010 460.609145 0.0024309263 5.900084e-01 7.129707e-01 11 126265021 126265079 59 - 2.636 2.669 0.112
ENSG00000182934 E011 510.010977 0.0004597176 7.624039e-01 8.459857e-01 11 126265080 126265172 93 - 2.692 2.707 0.048
ENSG00000182934 E012 847.551844 0.0004630159 5.653319e-04 2.403888e-03 11 126265268 126265440 173 - 2.941 2.907 -0.112
ENSG00000182934 E013 6.486153 0.0026096797 4.301451e-04 1.890493e-03 11 126265441 126265657 217 - 1.069 0.658 -1.596
ENSG00000182934 E014 681.687434 0.0009837487 1.037843e-02 2.969123e-02 11 126265737 126265823 87 - 2.845 2.813 -0.105
ENSG00000182934 E015 774.179773 0.0001248590 1.247775e-05 8.109614e-05 11 126265963 126266081 119 - 2.904 2.866 -0.128
ENSG00000182934 E016 631.211210 0.0014767984 3.532650e-02 8.227709e-02 11 126266187 126266278 92 - 2.810 2.781 -0.096
ENSG00000182934 E017 6.711861 0.0025139928 6.903322e-02 1.417715e-01 11 126266279 126266401 123 - 0.982 0.781 -0.770
ENSG00000182934 E018 830.898436 0.0011686950 6.704445e-02 1.384557e-01 11 126266476 126266629 154 - 2.922 2.905 -0.057
ENSG00000182934 E019 854.750410 0.0006946193 1.153250e-03 4.482252e-03 11 126266763 126266922 160 - 2.946 2.911 -0.117
ENSG00000182934 E020 4.421876 0.0449398390 5.418696e-04 2.316654e-03 11 126267174 126267174 1 - 0.966 0.396 -2.467
ENSG00000182934 E021 821.450162 0.0009357610 1.194924e-04 6.115592e-04 11 126267175 126267335 161 - 2.938 2.885 -0.174
ENSG00000182934 E022 11.132478 0.0016124929 5.103299e-05 2.869708e-04 11 126267336 126267548 213 - 1.259 0.876 -1.399
ENSG00000182934 E023 383.110849 0.0021245010 1.206434e-02 3.368836e-02 11 126267549 126267577 29 - 2.607 2.554 -0.175
ENSG00000182934 E024 584.834200 0.0005991893 1.396441e-03 5.294843e-03 11 126267578 126267712 135 - 2.782 2.743 -0.132
ENSG00000182934 E025 414.749802 0.0005451573 4.207696e-07 3.778967e-06 11 126268003 126268086 84 - 2.659 2.576 -0.277
ENSG00000182934 E026 401.227228 0.0048205134 3.375957e-03 1.136701e-02 11 126268688 126268867 180 - 2.648 2.556 -0.304
ENSG00000182934 E027 74.046798 0.0051687324 5.629964e-01 6.905379e-01 11 126268868 126268982 115 - 1.871 1.860 -0.038
ENSG00000182934 E028 0.000000       11 126268986 126269144 159 -