ENSG00000182871

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000651438 ENSG00000182871 HEK293_OSMI2_2hA HEK293_TMG_2hB COL18A1 protein_coding protein_coding 34.30154 45.5121 20.84394 3.233534 0.6459568 -1.126247 28.260395 39.619230 15.600675 2.714396 0.4026789 -1.3440320 0.8212000 0.8709 0.7487667 -0.1221333 7.780355e-10 7.780355e-10 FALSE TRUE
MSTRG.21489.1 ENSG00000182871 HEK293_OSMI2_2hA HEK293_TMG_2hB COL18A1 protein_coding   34.30154 45.5121 20.84394 3.233534 0.6459568 -1.126247 4.596478 3.904112 4.861825 1.965988 0.2733926 0.3157774 0.1392708 0.0809 0.2329000 0.1520000 5.406306e-01 7.780355e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182871 E001 0.3332198 0.0292181607 5.072872e-01   21 45405123 45405132 10 + 0.180 0.081 -1.319
ENSG00000182871 E002 6.8008065 0.0282257636 2.731524e-04 1.270386e-03 21 45405133 45405163 31 + 1.142 0.637 -1.949
ENSG00000182871 E003 6.9459792 0.0121924902 3.638128e-05 2.117718e-04 21 45405164 45405164 1 + 1.157 0.635 -2.013
ENSG00000182871 E004 40.6753482 0.0150686643 2.458757e-08 2.816058e-07 21 45405165 45405241 77 + 1.838 1.393 -1.517
ENSG00000182871 E005 75.2658137 0.0193256403 4.742962e-05 2.687423e-04 21 45405379 45405473 95 + 2.031 1.713 -1.071
ENSG00000182871 E006 0.0000000       21 45455522 45455530 9 +      
ENSG00000182871 E007 0.9975554 0.1500827320 7.034333e-01 8.021194e-01 21 45455531 45456176 646 + 0.180 0.267 0.722
ENSG00000182871 E008 0.1482932 0.0421383247 1.000000e+00   21 45456177 45456881 705 + 0.000 0.081 7.797
ENSG00000182871 E009 635.1408664 0.0020979692 1.641152e-13 4.528934e-12 21 45468242 45468786 545 + 2.871 2.683 -0.625
ENSG00000182871 E010 254.7989894 0.0011257595 7.248122e-07 6.205138e-06 21 45473895 45473981 87 + 2.442 2.300 -0.474
ENSG00000182871 E011 237.4956034 0.0009535136 5.333477e-08 5.714995e-07 21 45475476 45475535 60 + 2.421 2.265 -0.520
ENSG00000182871 E012 296.7843034 0.0002433118 1.210990e-06 9.881059e-06 21 45476351 45476480 130 + 2.489 2.375 -0.382
ENSG00000182871 E013 229.8969635 0.0031353084 2.485410e-01 3.842071e-01 21 45477411 45477487 77 + 2.331 2.288 -0.144
ENSG00000182871 E014 361.0512152 0.0002055819 7.763071e-01 8.559665e-01 21 45477750 45477965 216 + 2.498 2.489 -0.027
ENSG00000182871 E015 149.6416962 0.0003475387 2.765048e-01 4.159726e-01 21 45478327 45478353 27 + 2.141 2.102 -0.128
ENSG00000182871 E016 233.9056882 0.0002946053 2.364265e-01 3.700240e-01 21 45479902 45479964 63 + 2.330 2.296 -0.113
ENSG00000182871 E017 294.5029386 0.0014139494 1.062958e-02 3.028321e-02 21 45480070 45480156 87 + 2.461 2.387 -0.246
ENSG00000182871 E018 251.7930133 0.0002432249 2.362022e-03 8.344109e-03 21 45480467 45480520 54 + 2.394 2.315 -0.263
ENSG00000182871 E019 352.7573705 0.0008939825 5.245315e-01 6.580377e-01 21 45480700 45480858 159 + 2.468 2.485 0.055
ENSG00000182871 E020 248.4490876 0.0002162554 1.429803e-01 2.521028e-01 21 45481963 45482025 63 + 2.300 2.336 0.122
ENSG00000182871 E021 164.5371042 0.0002322749 8.544651e-01 9.099618e-01 21 45482795 45482821 27 + 2.158 2.150 -0.027
ENSG00000182871 E022 309.0165973 0.0001836601 9.888042e-01 9.970316e-01 21 45486861 45486992 132 + 2.424 2.422 -0.006
ENSG00000182871 E023 284.6537792 0.0011830483 4.499628e-01 5.911437e-01 21 45487447 45487509 63 + 2.403 2.382 -0.070
ENSG00000182871 E024 247.8051057 0.0002128178 9.298577e-02 1.797906e-01 21 45488418 45488444 27 + 2.359 2.314 -0.151
ENSG00000182871 E025 244.1975851 0.0001937330 3.566598e-02 8.293314e-02 21 45489486 45489521 36 + 2.361 2.305 -0.187
ENSG00000182871 E026 370.7175709 0.0001306736 3.102266e-02 7.396084e-02 21 45490275 45490346 72 + 2.536 2.489 -0.157
ENSG00000182871 E027 293.8140020 0.0001600974 9.973332e-01 1.000000e+00 21 45490836 45490871 36 + 2.404 2.401 -0.008
ENSG00000182871 E028 354.9791332 0.0001607406 4.771180e-01 6.157301e-01 21 45491225 45491314 90 + 2.497 2.479 -0.059
ENSG00000182871 E029 201.8773772 0.0002342501 4.774929e-01 6.160294e-01 21 45492535 45492564 30 + 2.224 2.242 0.061
ENSG00000182871 E030 205.6726183 0.0002011088 1.333194e-01 2.387281e-01 21 45492687 45492713 27 + 2.216 2.257 0.136
ENSG00000182871 E031 208.2627887 0.0001937012 1.346560e-01 2.406212e-01 21 45493163 45493194 32 + 2.221 2.262 0.135
ENSG00000182871 E032 210.9074752 0.0003135102 8.340218e-03 2.464252e-02 21 45493195 45493225 31 + 2.202 2.277 0.250
ENSG00000182871 E033 275.2106415 0.0001688550 4.989458e-03 1.589971e-02 21 45493501 45493575 75 + 2.322 2.390 0.228
ENSG00000182871 E034 215.5350411 0.0001786854 6.661393e-01 7.736429e-01 21 45494545 45494571 27 + 2.260 2.269 0.032
ENSG00000182871 E035 270.4367093 0.0001523207 5.049669e-01 6.408224e-01 21 45494862 45494915 54 + 2.354 2.369 0.047
ENSG00000182871 E036 364.3793141 0.0001341552 2.714397e-01 4.101995e-01 21 45495358 45495432 75 + 2.478 2.499 0.071
ENSG00000182871 E037 325.0481377 0.0001804668 7.234473e-01 8.172869e-01 21 45496500 45496568 69 + 2.441 2.447 0.019
ENSG00000182871 E038 295.3461905 0.0001831341 4.939282e-01 6.309596e-01 21 45497050 45497092 43 + 2.417 2.398 -0.061
ENSG00000182871 E039 307.3610142 0.0015697219 6.693097e-01 7.761495e-01 21 45497599 45497661 63 + 2.431 2.419 -0.040
ENSG00000182871 E040 3.0496396 0.0199349339 2.387218e-01 3.726650e-01 21 45497662 45497812 151 + 0.708 0.513 -0.863
ENSG00000182871 E041 248.5697993 0.0027867782 6.129676e-02 1.288172e-01 21 45504011 45504054 44 + 2.376 2.313 -0.212
ENSG00000182871 E042 212.6881148 0.0011392357 1.775679e-01 2.980845e-01 21 45504416 45504434 19 + 2.294 2.251 -0.143
ENSG00000182871 E043 286.2236902 0.0008769943 2.227890e-01 3.537003e-01 21 45504435 45504556 122 + 2.364 2.398 0.112
ENSG00000182871 E044 255.2686657 0.0001990167 2.259669e-08 2.608222e-07 21 45505134 45505278 145 + 2.223 2.372 0.499
ENSG00000182871 E045 191.8289332 0.0016572388 3.637236e-04 1.633587e-03 21 45505358 45505431 74 + 2.121 2.249 0.428
ENSG00000182871 E046 17.7195439 0.0039018113 4.406173e-01 5.823017e-01 21 45505835 45505837 3 + 1.267 1.194 -0.256
ENSG00000182871 E047 303.5712189 0.0001573988 3.449305e-06 2.548598e-05 21 45505838 45505966 129 + 2.328 2.439 0.371
ENSG00000182871 E048 8.9868735 0.0620607955 6.297636e-03 1.939444e-02 21 45506019 45507560 1542 + 1.216 0.780 -1.619
ENSG00000182871 E049 194.5675852 0.0002154447 4.993346e-09 6.518118e-08 21 45507561 45507593 33 + 2.078 2.259 0.606
ENSG00000182871 E050 323.2549116 0.0010364563 7.295843e-07 6.242325e-06 21 45509356 45509601 246 + 2.333 2.473 0.467
ENSG00000182871 E051 382.1507507 0.0002272376 2.893465e-07 2.687182e-06 21 45510064 45510261 198 + 2.428 2.540 0.374
ENSG00000182871 E052 428.8858629 0.0015229986 1.822390e-03 6.671556e-03 21 45511111 45511226 116 + 2.503 2.588 0.284
ENSG00000182871 E053 1249.0930732 0.0022728781 2.726950e-06 2.060434e-05 21 45512188 45513720 1533 + 2.942 3.060 0.392