ENSG00000182628

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330137 ENSG00000182628 HEK293_OSMI2_2hA HEK293_TMG_2hB SKA2 protein_coding protein_coding 47.662 35.62077 73.69399 1.455063 2.819614 1.048619 11.668032 6.117158 21.281907 0.5884765 1.0312303 1.79701524 0.2203958 0.17103333 0.28866667 0.117633333 8.527577e-07 8.527577e-07 FALSE TRUE
ENST00000578105 ENSG00000182628 HEK293_OSMI2_2hA HEK293_TMG_2hB SKA2 protein_coding protein_coding 47.662 35.62077 73.69399 1.455063 2.819614 1.048619 3.236478 2.108934 3.717024 0.6222732 1.3523340 0.81468536 0.0691125 0.06053333 0.05196667 -0.008566667 8.846500e-01 8.527577e-07   FALSE
ENST00000581068 ENSG00000182628 HEK293_OSMI2_2hA HEK293_TMG_2hB SKA2 protein_coding protein_coding 47.662 35.62077 73.69399 1.455063 2.819614 1.048619 19.630891 16.124565 31.066442 1.2215074 2.7284336 0.94566669 0.4143125 0.45156667 0.42003333 -0.031533333 6.979812e-01 8.527577e-07   FALSE
ENST00000583927 ENSG00000182628 HEK293_OSMI2_2hA HEK293_TMG_2hB SKA2 protein_coding processed_transcript 47.662 35.62077 73.69399 1.455063 2.819614 1.048619 6.343661 5.544785 5.827355 0.6024124 0.7338729 0.07158386 0.1521292 0.15483333 0.08000000 -0.074833333 1.806018e-02 8.527577e-07   FALSE
ENST00000583976 ENSG00000182628 HEK293_OSMI2_2hA HEK293_TMG_2hB SKA2 protein_coding nonsense_mediated_decay 47.662 35.62077 73.69399 1.455063 2.819614 1.048619 2.766537 2.387415 4.517302 0.2894174 0.6015275 0.91717194 0.0596375 0.06780000 0.06113333 -0.006666667 8.929607e-01 8.527577e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182628 E001 636.462577 0.0046057750 2.156194e-06 1.664838e-05 17 59109857 59111885 2029 - 2.846 2.681 -0.550
ENSG00000182628 E002 38.492034 0.0005634768 4.440203e-01 5.856007e-01 17 59111886 59111887 2 - 1.610 1.542 -0.235
ENSG00000182628 E003 35.288701 0.0006238425 2.396083e-01 3.736549e-01 17 59111888 59111889 2 - 1.583 1.486 -0.331
ENSG00000182628 E004 56.292818 0.0004358102 7.993924e-01 8.720330e-01 17 59111890 59111942 53 - 1.759 1.723 -0.123
ENSG00000182628 E005 42.888666 0.0005466230 6.604802e-01 7.691305e-01 17 59111943 59111955 13 - 1.630 1.630 0.002
ENSG00000182628 E006 131.694355 0.0021286834 4.521906e-04 1.975377e-03 17 59111956 59112046 91 - 2.164 2.002 -0.544
ENSG00000182628 E007 141.174296 0.0021955449 4.397023e-03 1.425593e-02 17 59112047 59112090 44 - 2.185 2.052 -0.446
ENSG00000182628 E008 410.158267 0.0001561170 1.542773e-03 5.774447e-03 17 59112091 59112261 171 - 2.591 2.622 0.103
ENSG00000182628 E009 381.783311 0.0001569527 2.171538e-10 3.613133e-09 17 59112262 59112345 84 - 2.535 2.624 0.298
ENSG00000182628 E010 3.798874 0.0042197993 7.832495e-01 8.608824e-01 17 59119299 59119318 20 - 0.689 0.628 -0.261
ENSG00000182628 E011 178.843655 0.0012768727 9.380792e-01 9.650802e-01 17 59119319 59119386 68 - 2.251 2.222 -0.097
ENSG00000182628 E012 209.150353 0.0022189181 4.591058e-01 5.993358e-01 17 59119387 59119495 109 - 2.326 2.274 -0.174
ENSG00000182628 E013 1.109218 0.0119546033 5.485905e-01 6.784309e-01 17 59124307 59124428 122 - 0.282 0.378 0.603
ENSG00000182628 E014 291.000155 0.0007552292 7.280556e-03 2.195291e-02 17 59131281 59131367 87 - 2.437 2.475 0.126
ENSG00000182628 E015 0.000000       17 59151769 59151801 33 -      
ENSG00000182628 E016 34.914991 0.0007119256 3.877744e-02 8.877239e-02 17 59154956 59155130 175 - 1.500 1.601 0.345
ENSG00000182628 E017 220.716641 0.0020281654 2.393505e-06 1.830611e-05 17 59155131 59155260 130 - 2.282 2.403 0.402