ENSG00000182606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341421 ENSG00000182606 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAK1 protein_coding protein_coding 14.65263 16.38479 11.95193 0.7637622 0.1266159 -0.4547873 3.352921 4.0377753 2.402809 0.1839482 0.06117487 -0.7464157 0.2263375 0.24753333 0.2009667 -0.04656667 0.310888099 0.007532191 FALSE TRUE
ENST00000673621 ENSG00000182606 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAK1 protein_coding protein_coding 14.65263 16.38479 11.95193 0.7637622 0.1266159 -0.4547873 2.964011 3.2823637 2.575254 0.2459759 0.26117111 -0.3488176 0.2008708 0.20090000 0.2150667 0.01416667 0.885875088 0.007532191 FALSE TRUE
MSTRG.22779.1 ENSG00000182606 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAK1 protein_coding   14.65263 16.38479 11.95193 0.7637622 0.1266159 -0.4547873 1.396658 0.8139067 2.602190 0.3054053 0.50385986 1.6647070 0.1068083 0.04816667 0.2185000 0.17033333 0.011345947 0.007532191 FALSE TRUE
MSTRG.22779.5 ENSG00000182606 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAK1 protein_coding   14.65263 16.38479 11.95193 0.7637622 0.1266159 -0.4547873 6.375304 7.8829561 4.043470 0.6520263 0.13284270 -0.9614081 0.4275667 0.48063333 0.3382000 -0.14243333 0.007532191 0.007532191 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182606 E001 7.0742026 0.0079708843 3.676438e-04 1.649005e-03 3 42013620 42013801 182 + 1.081 0.687 -1.516
ENSG00000182606 E002 37.2957131 0.0084367045 5.728871e-06 4.023271e-05 3 42013802 42014117 316 + 1.713 1.444 -0.919
ENSG00000182606 E003 2.9193184 0.0189703430 1.302515e-01 2.345121e-01 3 42086534 42086667 134 + 0.693 0.489 -0.917
ENSG00000182606 E004 48.8646953 0.0005858333 5.393919e-04 2.307727e-03 3 42087104 42087199 96 + 1.756 1.635 -0.410
ENSG00000182606 E005 94.9957042 0.0002914057 2.112386e-06 1.634677e-05 3 42087200 42087400 201 + 2.039 1.922 -0.395
ENSG00000182606 E006 0.2998086 0.0292194609 8.207749e-01   3 42091357 42091560 204 + 0.133 0.113 -0.269
ENSG00000182606 E007 117.3781559 0.0026835327 1.191183e-04 6.098742e-04 3 42125420 42125614 195 + 2.122 2.021 -0.335
ENSG00000182606 E008 0.0000000       3 42149235 42149358 124 +      
ENSG00000182606 E009 0.0000000       3 42149359 42149599 241 +      
ENSG00000182606 E010 0.0000000       3 42151335 42151432 98 +      
ENSG00000182606 E011 0.0000000       3 42160169 42160211 43 +      
ENSG00000182606 E012 0.3686942 0.0297093864 8.240145e-01 8.891139e-01 3 42160212 42160473 262 + 0.133 0.113 -0.263
ENSG00000182606 E013 87.0776444 0.0017228849 4.898835e-05 2.766723e-04 3 42176814 42176890 77 + 2.001 1.885 -0.389
ENSG00000182606 E014 97.7261386 0.0003911099 4.904951e-08 5.298370e-07 3 42184685 42184801 117 + 2.063 1.920 -0.478
ENSG00000182606 E015 0.1451727 0.0429961570 3.664358e-01   3 42184802 42184923 122 + 0.133 0.000 -11.567
ENSG00000182606 E016 75.1049246 0.0027329557 1.090152e-02 3.092511e-02 3 42188045 42188145 101 + 1.910 1.845 -0.221
ENSG00000182606 E017 86.0998185 0.0041681887 8.424338e-05 4.481161e-04 3 42189016 42189124 109 + 2.005 1.871 -0.452
ENSG00000182606 E018 89.2225431 0.0012076222 2.055785e-03 7.398039e-03 3 42191558 42191636 79 + 1.983 1.913 -0.236
ENSG00000182606 E019 52.2966182 0.0043349740 1.255184e-01 2.278956e-01 3 42193075 42193076 2 + 1.734 1.699 -0.118
ENSG00000182606 E020 108.5412687 0.0011728691 1.166222e-02 3.272901e-02 3 42193077 42193205 129 + 2.053 2.014 -0.132
ENSG00000182606 E021 87.0827464 0.0007088058 7.270342e-02 1.478472e-01 3 42193824 42193898 75 + 1.941 1.924 -0.058
ENSG00000182606 E022 101.0605995 0.0003000433 1.934920e-01 3.181627e-01 3 42194804 42194941 138 + 1.995 2.002 0.025
ENSG00000182606 E023 83.5120266 0.0003909151 8.953475e-03 2.616314e-02 3 42199177 42199253 77 + 1.945 1.896 -0.163
ENSG00000182606 E024 145.3309679 0.0030888365 1.266325e-02 3.511747e-02 3 42200818 42201054 237 + 2.181 2.138 -0.142
ENSG00000182606 E025 54.0837131 0.0209674970 3.282391e-01 4.717300e-01 3 42202436 42202449 14 + 1.745 1.718 -0.095
ENSG00000182606 E026 137.9395424 0.0016362223 9.861380e-01 9.953376e-01 3 42202450 42202702 253 + 2.100 2.155 0.184
ENSG00000182606 E027 64.4776790 0.0016086039 7.536161e-01 8.394935e-01 3 42202703 42202752 50 + 1.785 1.823 0.130
ENSG00000182606 E028 9.7192642 0.0022286242 4.243001e-07 3.807246e-06 3 42202753 42204189 1437 + 0.497 1.192 2.764
ENSG00000182606 E029 126.1909052 0.0007288114 4.905179e-01 6.278687e-01 3 42209767 42209922 156 + 2.076 2.107 0.103
ENSG00000182606 E030 52.6876498 0.0004699498 2.318936e-01 3.647134e-01 3 42209923 42209985 63 + 1.649 1.761 0.381
ENSG00000182606 E031 296.3596933 0.0064709390 1.080373e-07 1.090661e-06 3 42209986 42212623 2638 + 2.278 2.560 0.941
ENSG00000182606 E032 88.0075548 0.0003144170 1.165348e-03 4.523361e-03 3 42219494 42219596 103 + 1.977 1.908 -0.233
ENSG00000182606 E033 0.2965864 0.2612550065 3.694192e-01   3 42220499 42220591 93 + 0.000 0.198 10.680
ENSG00000182606 E034 1002.7904763 0.0029535359 4.876744e-11 9.079054e-10 3 42222942 42225890 2949 + 2.865 3.063 0.659