ENSG00000182473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332065 ENSG00000182473 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC7 protein_coding protein_coding 70.70827 106.8213 49.87843 4.775898 0.5885988 -1.098557 44.074553 65.676043 29.0297191 4.3212208 0.40777650 -1.1775594 0.61480833 0.61396667 0.5820667 -0.03190000 6.196513e-01 1.828384e-10 FALSE  
ENST00000465252 ENSG00000182473 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC7 protein_coding retained_intron 70.70827 106.8213 49.87843 4.775898 0.5885988 -1.098557 3.447102 8.882908 0.7435047 3.0913017 0.07068693 -3.5609669 0.04044167 0.08566667 0.0149000 -0.07076667 1.980155e-02 1.828384e-10 FALSE  
ENST00000589210 ENSG00000182473 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC7 protein_coding protein_coding 70.70827 106.8213 49.87843 4.775898 0.5885988 -1.098557 11.151413 20.578579 6.4354384 2.1040900 0.35110142 -1.6754939 0.14852083 0.19160000 0.1290333 -0.06256667 2.372494e-02 1.828384e-10 FALSE  
ENST00000634349 ENSG00000182473 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC7 protein_coding protein_coding 70.70827 106.8213 49.87843 4.775898 0.5885988 -1.098557 4.304985 5.195243 6.3271611 0.6390934 0.15446609 0.2838712 0.07204167 0.04840000 0.1269000 0.07850000 1.828384e-10 1.828384e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182473 E001 17.3765484 0.0078141474 2.262591e-04 1.075771e-03 17 76081016 76081016 1 - 0.844 1.298 1.657
ENSG00000182473 E002 17.3765484 0.0078141474 2.262591e-04 1.075771e-03 17 76081017 76081017 1 - 0.844 1.298 1.657
ENSG00000182473 E003 703.9285298 0.0022326977 9.967738e-15 3.280108e-13 17 76081018 76081246 229 - 2.593 2.844 0.837
ENSG00000182473 E004 3072.2475560 0.0033726578 9.935549e-12 2.070693e-10 17 76081247 76082390 1144 - 3.267 3.477 0.698
ENSG00000182473 E005 296.8949009 0.0001569017 9.251009e-08 9.450906e-07 17 76082391 76082391 1 - 2.290 2.452 0.541
ENSG00000182473 E006 1554.2890343 0.0017303646 8.520969e-08 8.766331e-07 17 76082392 76082891 500 - 3.020 3.169 0.495
ENSG00000182473 E007 1621.4879895 0.0007447507 5.921818e-06 4.146783e-05 17 76082892 76083518 627 - 3.074 3.177 0.344
ENSG00000182473 E008 396.9388279 0.0001741874 2.102460e-01 3.388386e-01 17 76083519 76083575 57 - 2.499 2.555 0.184
ENSG00000182473 E009 214.3615454 0.0002009399 1.935883e-02 5.011098e-02 17 76083576 76083576 1 - 2.201 2.297 0.319
ENSG00000182473 E010 461.8737717 0.0001512262 5.882014e-02 1.246106e-01 17 76083577 76083647 71 - 2.558 2.624 0.219
ENSG00000182473 E011 600.3830866 0.0002469645 2.056687e-01 3.332656e-01 17 76083648 76083750 103 - 2.682 2.734 0.173
ENSG00000182473 E012 734.2246851 0.0003775682 7.533214e-01 8.393043e-01 17 76084006 76084139 134 - 2.782 2.817 0.118
ENSG00000182473 E013 446.8054767 0.0004388102 3.825872e-01 5.267940e-01 17 76084248 76084289 42 - 2.586 2.597 0.038
ENSG00000182473 E014 7.4990549 0.0023938877 2.587894e-02 6.369442e-02 17 76084290 76084516 227 - 1.040 0.801 -0.906
ENSG00000182473 E015 536.9677005 0.0001740554 5.076349e-02 1.105300e-01 17 76084517 76084580 64 - 2.677 2.672 -0.019
ENSG00000182473 E016 8.0210262 0.0101949175 2.359332e-02 5.897380e-02 17 76084581 76084716 136 - 1.078 0.828 -0.934
ENSG00000182473 E017 6.0420188 0.0027971549 3.321158e-01 4.757472e-01 17 76085110 76085313 204 - 0.874 0.770 -0.405
ENSG00000182473 E018 428.6921308 0.0001614535 2.542825e-01 3.909421e-01 17 76085314 76085368 55 - 2.569 2.576 0.022
ENSG00000182473 E019 396.9298735 0.0008985055 7.257718e-01 8.189684e-01 17 76085369 76085409 41 - 2.525 2.547 0.073
ENSG00000182473 E020 498.2664935 0.0018959272 2.539530e-01 3.905750e-01 17 76085677 76085797 121 - 2.639 2.640 0.002
ENSG00000182473 E021 316.7129226 0.0011315542 2.553552e-01 3.922220e-01 17 76086080 76086145 66 - 2.442 2.442 -0.003
ENSG00000182473 E022 0.3332198 0.0305143866 5.031542e-01   17 76086854 76086892 39 - 0.176 0.084 -1.228
ENSG00000182473 E023 1.5983211 0.0599971268 2.093146e-03 7.512652e-03 17 76087277 76087653 377 - 0.698 0.155 -3.223
ENSG00000182473 E024 350.3983485 0.0002215198 4.137681e-01 5.571776e-01 17 76087654 76087720 67 - 2.477 2.488 0.037
ENSG00000182473 E025 29.7270318 0.0185854813 6.397898e-05 3.509461e-04 17 76087721 76088059 339 - 1.647 1.313 -1.149
ENSG00000182473 E026 383.8511836 0.0004283004 8.282885e-01 8.920872e-01 17 76088060 76088122 63 - 2.507 2.532 0.083
ENSG00000182473 E027 40.3844963 0.0006252641 9.199730e-12 1.928584e-10 17 76088123 76088463 341 - 1.787 1.431 -1.216
ENSG00000182473 E028 487.2917570 0.0006270919 1.672334e-03 6.194518e-03 17 76088464 76088562 99 - 2.656 2.620 -0.121
ENSG00000182473 E029 545.6336039 0.0005580649 7.414033e-07 6.335151e-06 17 76088771 76088923 153 - 2.728 2.660 -0.225
ENSG00000182473 E030 531.4713786 0.0003422905 3.293320e-13 8.696816e-12 17 76089175 76089320 146 - 2.742 2.637 -0.349
ENSG00000182473 E031 43.2906758 0.0134896712 1.974925e-07 1.893823e-06 17 76089321 76089808 488 - 1.831 1.454 -1.282
ENSG00000182473 E032 89.9423487 0.0003624983 1.318200e-04 6.668687e-04 17 76090329 76090397 69 - 1.987 1.862 -0.423
ENSG00000182473 E033 16.3580787 0.0244675071 1.290136e-05 8.352268e-05 17 76090398 76090481 84 - 1.469 1.015 -1.605
ENSG00000182473 E034 150.7366798 0.0009345608 2.331145e-05 1.423322e-04 17 76091143 76091235 93 - 2.201 2.086 -0.384
ENSG00000182473 E035 102.9950007 0.0054837965 1.667276e-21 1.261927e-19 17 76092315 76094413 2099 - 2.235 1.789 -1.498
ENSG00000182473 E036 442.1337767 0.0007605867 1.076729e-09 1.587169e-08 17 76094414 76094510 97 - 2.663 2.557 -0.351
ENSG00000182473 E037 413.4633377 0.0005005276 8.033781e-11 1.440719e-09 17 76094511 76094581 71 - 2.635 2.526 -0.363
ENSG00000182473 E038 480.1536565 0.0012083479 2.021211e-10 3.384411e-09 17 76097796 76097913 118 - 2.710 2.589 -0.402
ENSG00000182473 E039 395.0311589 0.0021020146 7.678012e-08 7.973340e-07 17 76097914 76097988 75 - 2.628 2.503 -0.415
ENSG00000182473 E040 298.9896924 0.0021073635 6.276016e-07 5.444012e-06 17 76097989 76098018 30 - 2.507 2.384 -0.411
ENSG00000182473 E041 2.9159933 0.0713869862 6.580990e-01 7.672961e-01 17 76101012 76101270 259 - 0.601 0.546 -0.247
ENSG00000182473 E042 456.8659775 0.0009050843 3.911681e-12 8.706017e-11 17 76101271 76101376 106 - 2.692 2.565 -0.422
ENSG00000182473 E043 548.7628746 0.0043098396 2.496608e-05 1.514101e-04 17 76101679 76101863 185 - 2.764 2.650 -0.382
ENSG00000182473 E044 1.6983276 0.0081333665 2.791319e-03 9.648002e-03 17 76103084 76103360 277 - 0.698 0.214 -2.644
ENSG00000182473 E045 314.3202078 0.0049375885 1.121221e-03 4.374486e-03 17 76103361 76103426 66 - 2.510 2.413 -0.324
ENSG00000182473 E046 2.2456031 0.0095751579 1.883091e-01 3.116039e-01 17 76103427 76103523 97 - 0.601 0.396 -1.003
ENSG00000182473 E047 273.5803306 0.0121510014 2.900408e-02 7.001448e-02 17 76103633 76103677 45 - 2.445 2.356 -0.296
ENSG00000182473 E048 210.0015908 0.0167431567 4.405997e-02 9.849351e-02 17 76103678 76103787 110 - 2.336 2.239 -0.323
ENSG00000182473 E049 2.6247030 0.0601374933 5.047626e-01 6.406490e-01 17 76120331 76120454 124 - 0.397 0.551 0.773
ENSG00000182473 E050 2.6214953 0.0728307786 8.328753e-01 8.952991e-01 17 76120864 76120978 115 - 0.476 0.546 0.338
ENSG00000182473 E051 1.2898899 0.0113367296 5.886661e-01 7.118575e-01 17 76121428 76121576 149 - 0.397 0.314 -0.493