ENSG00000182446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331134 ENSG00000182446 HEK293_OSMI2_2hA HEK293_TMG_2hB NPLOC4 protein_coding protein_coding 65.25966 91.35176 50.6379 3.303134 1.447243 -0.8510882 54.470833 82.060334 41.707882 2.5414320 0.8075393 -0.97619491 0.82523750 0.89863333 0.82413333 -0.07450000 7.611878e-05 3.687145e-05 FALSE  
ENST00000574964 ENSG00000182446 HEK293_OSMI2_2hA HEK293_TMG_2hB NPLOC4 protein_coding processed_transcript 65.25966 91.35176 50.6379 3.303134 1.447243 -0.8510882 4.003081 3.488844 3.335238 0.2103004 0.4004636 -0.06476947 0.06233333 0.03826667 0.06563333 0.02736667 1.760205e-02 3.687145e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182446 E001 4028.2690632 0.0042801380 5.254859e-16 2.058981e-14 17 81556887 81558788 1902 - 3.389 3.641 0.838
ENSG00000182446 E002 688.9214416 0.0002136653 7.181885e-10 1.095480e-08 17 81558789 81559013 225 - 2.709 2.848 0.462
ENSG00000182446 E003 357.6262142 0.0002807367 2.864508e-04 1.324787e-03 17 81559014 81559063 50 - 2.440 2.558 0.394
ENSG00000182446 E004 319.4098943 0.0001495177 1.060560e-01 1.996917e-01 17 81559064 81559090 27 - 2.422 2.497 0.249
ENSG00000182446 E005 358.9165192 0.0007510056 3.213717e-01 4.646060e-01 17 81559091 81559124 34 - 2.482 2.545 0.210
ENSG00000182446 E006 396.5323053 0.0008169127 8.087797e-03 2.400302e-02 17 81559125 81559181 57 - 2.496 2.598 0.340
ENSG00000182446 E007 472.6931258 0.0001713279 2.840046e-02 6.881779e-02 17 81559182 81559267 86 - 2.588 2.668 0.265
ENSG00000182446 E008 374.3654621 0.0009831955 6.772464e-03 2.063202e-02 17 81559268 81559315 48 - 2.468 2.575 0.357
ENSG00000182446 E009 419.5612468 0.0001631950 1.086954e-06 8.953440e-06 17 81559316 81559395 80 - 2.495 2.631 0.451
ENSG00000182446 E010 273.8662253 0.0001588327 8.868221e-07 7.448386e-06 17 81559396 81559416 21 - 2.295 2.453 0.527
ENSG00000182446 E011 25.3423886 0.0022220950 4.115413e-01 5.550961e-01 17 81560562 81560629 68 - 1.401 1.377 -0.082
ENSG00000182446 E012 35.8605544 0.0032611540 4.689449e-01 6.082862e-01 17 81560721 81560889 169 - 1.540 1.530 -0.034
ENSG00000182446 E013 75.5892352 0.0003703993 2.127340e-04 1.018546e-03 17 81561766 81563412 1647 - 1.928 1.811 -0.393
ENSG00000182446 E014 15.1548225 0.0828776393 2.318070e-01 3.646015e-01 17 81563413 81563568 156 - 1.301 1.104 -0.701
ENSG00000182446 E015 25.2732112 0.0340672179 1.921841e-02 4.981012e-02 17 81563569 81563920 352 - 1.524 1.298 -0.782
ENSG00000182446 E016 17.0645639 0.0029252042 2.445620e-02 6.076109e-02 17 81563921 81563979 59 - 1.319 1.162 -0.555
ENSG00000182446 E017 14.2716470 0.0012795005 1.486817e-03 5.593684e-03 17 81563980 81564212 233 - 1.301 1.053 -0.883
ENSG00000182446 E018 7.9964359 0.0035360695 8.276581e-02 1.638837e-01 17 81564213 81564246 34 - 1.021 0.854 -0.629
ENSG00000182446 E019 29.4255961 0.0199668818 7.464290e-04 3.065572e-03 17 81564247 81564908 662 - 1.615 1.347 -0.919
ENSG00000182446 E020 32.3752589 0.0039230017 4.219546e-04 1.858592e-03 17 81564909 81565504 596 - 1.614 1.413 -0.692
ENSG00000182446 E021 443.7634392 0.0001659793 7.820856e-03 2.333104e-02 17 81565505 81565607 103 - 2.553 2.643 0.299
ENSG00000182446 E022 0.1451727 0.0431373898 2.575819e-01   17 81566388 81566470 83 - 0.156 0.000 -22.879
ENSG00000182446 E023 0.2924217 0.0290785164 7.614166e-02   17 81566471 81566635 165 - 0.270 0.000 -23.884
ENSG00000182446 E024 0.0000000       17 81566875 81566985 111 -      
ENSG00000182446 E025 530.1392439 0.0001381295 1.557225e-02 4.178399e-02 17 81567417 81567533 117 - 2.695 2.693 -0.005
ENSG00000182446 E026 0.2934659 0.0291058657 6.310253e-01   17 81567934 81567953 20 - 0.156 0.095 -0.818
ENSG00000182446 E027 4.5555991 0.0046837087 1.842920e-01 3.066156e-01 17 81567954 81568075 122 - 0.555 0.789 0.990
ENSG00000182446 E028 496.4012139 0.0015785019 3.257921e-02 7.696187e-02 17 81569016 81569111 96 - 2.674 2.660 -0.046
ENSG00000182446 E029 388.4639968 0.0016167463 7.540725e-03 2.262003e-02 17 81572017 81572088 72 - 2.580 2.548 -0.107
ENSG00000182446 E030 1.5780558 0.0089248383 1.139206e-01 2.112394e-01 17 81572089 81572108 20 - 0.156 0.472 2.184
ENSG00000182446 E031 0.3697384 0.0250710171 4.421009e-01 5.837504e-01 17 81588091 81588187 97 - 0.000 0.173 21.999
ENSG00000182446 E032 546.6255527 0.0012197699 1.788984e-04 8.732065e-04 17 81588944 81589104 161 - 2.738 2.692 -0.152
ENSG00000182446 E033 501.4787215 0.0009021556 5.361161e-09 6.956070e-08 17 81596116 81596242 127 - 2.726 2.641 -0.285
ENSG00000182446 E034 463.1822467 0.0005432766 3.944716e-11 7.446339e-10 17 81597245 81597316 72 - 2.697 2.604 -0.308
ENSG00000182446 E035 1.6962749 0.1215696457 7.395070e-01 8.291797e-01 17 81597317 81597319 3 - 0.436 0.395 -0.225
ENSG00000182446 E036 479.9376720 0.0003579915 1.039146e-12 2.544438e-11 17 81600341 81600427 87 - 2.712 2.619 -0.311
ENSG00000182446 E037 282.4516314 0.0006882285 2.536074e-06 1.929370e-05 17 81604548 81604571 24 - 2.472 2.395 -0.260
ENSG00000182446 E038 365.2302926 0.0008103260 3.365436e-10 5.427528e-09 17 81604572 81604608 37 - 2.601 2.495 -0.355
ENSG00000182446 E039 391.5448748 0.0003942148 3.618979e-11 6.870476e-10 17 81604609 81604663 55 - 2.625 2.529 -0.320
ENSG00000182446 E040 402.0963417 0.0011737344 8.566673e-10 1.285184e-08 17 81604664 81604727 64 - 2.646 2.537 -0.362
ENSG00000182446 E041 471.0585502 0.0039308252 2.663785e-05 1.604241e-04 17 81606691 81606814 124 - 2.711 2.608 -0.340
ENSG00000182446 E042 356.3486476 0.0025346460 6.204494e-05 3.415338e-04 17 81608728 81608800 73 - 2.577 2.494 -0.276
ENSG00000182446 E043 222.2793094 0.0007968010 1.026079e-04 5.341053e-04 17 81608801 81608810 10 - 2.364 2.296 -0.228
ENSG00000182446 E044 220.7391471 0.0025792636 1.014780e-03 4.009907e-03 17 81608811 81608822 12 - 2.364 2.290 -0.247
ENSG00000182446 E045 4.0354436 0.0960587872 1.186825e-01 2.180630e-01 17 81608823 81608919 97 - 0.847 0.569 -1.157
ENSG00000182446 E046 285.1389213 0.0004221588 4.538787e-06 3.262743e-05 17 81610210 81610258 49 - 2.471 2.403 -0.229
ENSG00000182446 E047 2.9023865 0.0055841067 7.876178e-03 2.346873e-02 17 81612679 81612873 195 - 0.156 0.670 3.092
ENSG00000182446 E048 0.4482035 0.0325096796 2.296154e-02 5.766547e-02 17 81613050 81613125 76 - 0.361 0.000 -24.469
ENSG00000182446 E049 525.0384569 0.0006630881 1.801071e-10 3.041336e-09 17 81613318 81613494 177 - 2.747 2.660 -0.290
ENSG00000182446 E050 0.1817044 0.0396409236 9.229516e-01   17 81614318 81614381 64 - 0.000 0.095 21.003
ENSG00000182446 E051 335.0322265 0.0044685461 1.178625e-03 4.568905e-03 17 81622166 81622278 113 - 2.549 2.468 -0.269
ENSG00000182446 E052 234.0600739 0.0112207018 4.949099e-06 3.525444e-05 17 81629725 81629805 81 - 2.474 2.259 -0.717
ENSG00000182446 E053 0.3332198 0.0297026274 6.316728e-01   17 81629864 81629875 12 - 0.156 0.095 -0.816
ENSG00000182446 E054 0.6653823 0.0172671820 9.979788e-02 1.901785e-01 17 81636397 81636478 82 - 0.361 0.095 -2.399
ENSG00000182446 E055 154.0963329 0.0308121997 1.357135e-05 8.742694e-05 17 81636916 81637112 197 - 2.360 2.021 -1.134
ENSG00000182446 E056 0.0000000       17 81648430 81648465 36 -