ENSG00000182400

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330149 ENSG00000182400 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6B protein_coding protein_coding 9.56907 2.997277 16.05192 0.3314901 0.8988134 2.417115 6.0134164 2.54383813 9.7499850 0.18142387 0.77354610 1.934212 0.65939583 0.859700000 0.60620000 -0.25350000 1.432284e-01 5.774136e-06 FALSE  
ENST00000347691 ENSG00000182400 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6B protein_coding protein_coding 9.56907 2.997277 16.05192 0.3314901 0.8988134 2.417115 1.7135982 0.38914091 2.5915383 0.19486380 0.33372578 2.704395 0.18187500 0.121100000 0.16346667 0.04236667 7.720440e-01 5.774136e-06 FALSE  
ENST00000555269 ENSG00000182400 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6B protein_coding nonsense_mediated_decay 9.56907 2.997277 16.05192 0.3314901 0.8988134 2.417115 0.6384549 0.03526322 1.1487850 0.03526322 0.58472560 4.678130 0.05289167 0.009766667 0.07436667 0.06460000 6.570322e-01 5.774136e-06    
ENST00000556765 ENSG00000182400 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6B protein_coding nonsense_mediated_decay 9.56907 2.997277 16.05192 0.3314901 0.8988134 2.417115 0.2057475 0.00000000 1.0088206 0.00000000 0.87177167 6.670756 0.01220417 0.000000000 0.05933333 0.05933333 5.703435e-01 5.774136e-06    
MSTRG.9437.6 ENSG00000182400 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6B protein_coding   9.56907 2.997277 16.05192 0.3314901 0.8988134 2.417115 0.3979265 0.00000000 0.9741533 0.00000000 0.05194008 6.620811 0.02946250 0.000000000 0.06073333 0.06073333 5.774136e-06 5.774136e-06    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182400 E001 1.932461 0.0094774788 3.015524e-01 4.433733e-01 14 39143212 39143279 68 - 0.437 0.239 -1.245
ENSG00000182400 E002 0.590154 0.0197576919 7.076879e-01 8.055165e-01 14 39147811 39147811 1 - 0.156 0.238 0.754
ENSG00000182400 E003 0.590154 0.0197576919 7.076879e-01 8.055165e-01 14 39147812 39147813 2 - 0.156 0.238 0.754
ENSG00000182400 E004 169.610329 0.0070910963 6.925152e-18 3.458870e-16 14 39147814 39148381 568 - 2.014 2.434 1.404
ENSG00000182400 E005 230.972290 0.0004422219 8.269221e-13 2.058309e-11 14 39148382 39149324 943 - 2.212 2.431 0.730
ENSG00000182400 E006 72.625389 0.0071061693 7.776151e-01 8.569055e-01 14 39149325 39149500 176 - 1.763 1.775 0.041
ENSG00000182400 E007 78.816322 0.0003854887 1.936520e-01 3.183816e-01 14 39149501 39149987 487 - 1.807 1.780 -0.091
ENSG00000182400 E008 10.694063 0.0016505842 6.112184e-01 7.303761e-01 14 39149988 39149989 2 - 0.986 0.957 -0.107
ENSG00000182400 E009 50.672417 0.0047599443 8.734090e-03 2.562127e-02 14 39149990 39150117 128 - 1.640 1.481 -0.543
ENSG00000182400 E010 90.007458 0.0005431447 3.223266e-06 2.395316e-05 14 39150118 39150381 264 - 1.890 1.687 -0.687
ENSG00000182400 E011 54.300118 0.0017167585 2.657548e-04 1.240128e-03 14 39151746 39151796 51 - 1.675 1.460 -0.733
ENSG00000182400 E012 48.836395 0.0169175459 1.369279e-02 3.752109e-02 14 39151797 39151810 14 - 1.626 1.429 -0.675
ENSG00000182400 E013 52.503225 0.0005707329 4.497688e-04 1.965749e-03 14 39151811 39151839 29 - 1.658 1.460 -0.678
ENSG00000182400 E014 50.857562 0.0004429005 1.769195e-03 6.501188e-03 14 39154211 39154294 84 - 1.643 1.471 -0.588
ENSG00000182400 E015 68.411337 0.0003964392 8.327956e-06 5.634867e-05 14 39158285 39158402 118 - 1.777 1.549 -0.774
ENSG00000182400 E016 5.281976 0.0219105990 3.332193e-01 4.769119e-01 14 39158403 39159449 1047 - 0.739 0.594 -0.614
ENSG00000182400 E017 5.475437 0.0030064637 9.361572e-02 1.807788e-01 14 39159450 39159482 33 - 0.772 0.505 -1.162
ENSG00000182400 E018 59.880858 0.0006354954 1.772902e-03 6.512786e-03 14 39159483 39159550 68 - 1.713 1.558 -0.526
ENSG00000182400 E019 37.355009 0.0159089604 2.913003e-02 7.025344e-02 14 39170015 39170017 3 - 1.518 1.342 -0.605
ENSG00000182400 E020 100.211699 0.0050446856 4.602262e-04 2.007378e-03 14 39170018 39170532 515 - 1.933 1.763 -0.571