ENSG00000182287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329235 ENSG00000182287 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1S2 protein_coding protein_coding 24.03947 11.47705 43.04866 1.720878 1.993714 1.906295 17.248904 9.72510046 27.821566 1.55893371 1.4018904 1.515454 0.76186250 0.84626667 0.64660000 -0.1996667 8.049633e-05 4.515853e-07 FALSE TRUE
ENST00000380291 ENSG00000182287 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1S2 protein_coding protein_coding 24.03947 11.47705 43.04866 1.720878 1.993714 1.906295 1.166420 0.39083611 2.242310 0.07299491 0.2463338 2.490321 0.05318333 0.03573333 0.05223333 0.0165000 4.356356e-01 4.515853e-07 FALSE TRUE
MSTRG.33927.4 ENSG00000182287 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1S2 protein_coding   24.03947 11.47705 43.04866 1.720878 1.993714 1.906295 1.959327 0.04934572 5.352648 0.04934572 0.8730941 6.497658 0.05431667 0.00460000 0.12386667 0.1192667 2.974895e-05 4.515853e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182287 E001 6.7785616 0.0029493274 7.906347e-01 8.660877e-01 X 15825806 15825856 51 - 0.839 0.897 0.220
ENSG00000182287 E002 25.1267033 0.0080602501 3.312598e-05 1.949495e-04 X 15825857 15825926 70 - 1.241 1.606 1.261
ENSG00000182287 E003 37.3286021 0.0097165797 4.694201e-07 4.175128e-06 X 15825927 15825984 58 - 1.388 1.791 1.376
ENSG00000182287 E004 423.5340468 0.0030751926 1.756483e-15 6.433718e-14 X 15825985 15826706 722 - 2.501 2.748 0.823
ENSG00000182287 E005 169.1723093 0.0009149678 1.074264e-08 1.317085e-07 X 15826707 15826886 180 - 2.124 2.325 0.671
ENSG00000182287 E006 53.9007309 0.0032370980 4.482742e-01 5.895794e-01 X 15826887 15826891 5 - 1.675 1.739 0.217
ENSG00000182287 E007 81.0790784 0.0040099626 3.390323e-02 7.955588e-02 X 15826892 15826932 41 - 1.831 1.958 0.428
ENSG00000182287 E008 92.6450170 0.0022727635 5.701747e-01 6.966739e-01 X 15826933 15826986 54 - 1.915 1.965 0.169
ENSG00000182287 E009 88.1883792 0.0033287515 8.454840e-01 9.039137e-01 X 15826987 15827028 42 - 1.904 1.922 0.059
ENSG00000182287 E010 233.4540173 0.0001934838 5.416232e-01 6.725874e-01 X 15827029 15827241 213 - 2.314 2.355 0.135
ENSG00000182287 E011 226.1168133 0.0002953203 1.731999e-01 2.923527e-01 X 15827242 15827372 131 - 2.314 2.302 -0.038
ENSG00000182287 E012 3.4052923 0.0044715089 6.932381e-03 2.104880e-02 X 15828192 15828200 9 - 0.704 0.197 -2.824
ENSG00000182287 E013 3.8971937 0.0173528397 4.346571e-02 9.740529e-02 X 15830059 15830137 79 - 0.532 0.864 1.392
ENSG00000182287 E014 22.1718373 0.0098092782 2.523520e-01 3.886900e-01 X 15830138 15830231 94 - 1.285 1.416 0.455
ENSG00000182287 E015 92.3344091 0.0043415662 8.242354e-01 8.892794e-01 X 15830232 15831289 1058 - 1.916 1.958 0.141
ENSG00000182287 E016 16.6426102 0.0170826252 5.965008e-01 7.184427e-01 X 15831290 15831451 162 - 1.218 1.183 -0.122
ENSG00000182287 E017 17.5821693 0.0091851258 1.186227e-01 2.179721e-01 X 15831452 15831568 117 - 1.259 1.116 -0.510
ENSG00000182287 E018 69.7792999 0.0004017058 5.153095e-22 4.113942e-20 X 15831569 15833007 1439 - 1.903 1.347 -1.897
ENSG00000182287 E019 19.7957027 0.0100230768 2.923336e-03 1.003983e-02 X 15833444 15833524 81 - 1.336 1.033 -1.079
ENSG00000182287 E020 1.7820913 0.0081333665 1.630557e-02 4.340187e-02 X 15840497 15840591 95 - 0.507 0.000 -11.148
ENSG00000182287 E021 246.2702434 0.0044204364 2.069186e-02 5.293951e-02 X 15845379 15845516 138 - 2.367 2.290 -0.259
ENSG00000182287 E022 168.4199649 0.0002311134 1.118550e-05 7.348913e-05 X 15845903 15846011 109 - 2.213 2.100 -0.378
ENSG00000182287 E023 182.3978577 0.0023303294 4.417011e-09 5.813057e-08 X 15852346 15852501 156 - 2.267 2.062 -0.686
ENSG00000182287 E024 74.9110968 0.0006109648 3.282372e-15 1.160574e-13 X 15852502 15852524 23 - 1.917 1.512 -1.371
ENSG00000182287 E025 0.7665478 0.0295035483 8.075350e-01 8.777264e-01 X 15852850 15852906 57 - 0.240 0.197 -0.363
ENSG00000182287 E026 94.2417921 0.0021794673 5.313237e-18 2.687789e-16 X 15854688 15854931 244 - 2.021 1.576 -1.503