ENSG00000182272

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329962 ENSG00000182272 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT4 protein_coding protein_coding 15.96438 23.48521 14.37107 3.529708 0.1684143 -0.7081951 1.2262728 0.8935858 1.7430516 0.8935858 0.27437829 0.9561349 0.07459583 0.02926667 0.1215333 0.092266667 0.123717827 0.003577606 FALSE TRUE
ENST00000524443 ENSG00000182272 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT4 protein_coding retained_intron 15.96438 23.48521 14.37107 3.529708 0.1684143 -0.7081951 1.6969353 2.0071045 2.2641076 0.3551565 0.31873917 0.1730147 0.11320833 0.08506667 0.1571000 0.072033333 0.021721915 0.003577606 FALSE FALSE
ENST00000526584 ENSG00000182272 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT4 protein_coding nonsense_mediated_decay 15.96438 23.48521 14.37107 3.529708 0.1684143 -0.7081951 3.3631103 5.9579609 2.1102823 1.0483408 0.11587235 -1.4929817 0.19974167 0.25323333 0.1469667 -0.106266667 0.008424543 0.003577606   FALSE
ENST00000530717 ENSG00000182272 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT4 protein_coding retained_intron 15.96438 23.48521 14.37107 3.529708 0.1684143 -0.7081951 0.9280356 0.6036712 1.7386130 0.3659600 0.39659745 1.5106732 0.05817500 0.02256667 0.1214000 0.098833333 0.015349491 0.003577606 FALSE TRUE
MSTRG.4885.3 ENSG00000182272 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT4 protein_coding   15.96438 23.48521 14.37107 3.529708 0.1684143 -0.7081951 5.4077037 9.1080820 4.0089457 1.4281352 0.15251025 -1.1819133 0.34223750 0.38746667 0.2787667 -0.108700000 0.003577606 0.003577606 FALSE TRUE
MSTRG.4885.5 ENSG00000182272 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT4 protein_coding   15.96438 23.48521 14.37107 3.529708 0.1684143 -0.7081951 0.9083836 1.1920575 0.8763046 0.1704437 0.06071871 -0.4396315 0.05988750 0.05376667 0.0609000 0.007133333 0.823628498 0.003577606 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182272 E001 1.269254 0.1120000523 6.619496e-03 2.023891e-02 11 369499 369539 41 + 0.616 0.093 -3.710
ENSG00000182272 E002 7.602943 0.0025566959 1.061926e-04 5.504918e-04 11 369540 369795 256 + 1.144 0.702 -1.680
ENSG00000182272 E003 36.196639 0.0077932288 1.823328e-01 3.041400e-01 11 369796 369954 159 + 1.585 1.498 -0.298
ENSG00000182272 E004 70.971002 0.0020680681 7.252794e-02 1.475585e-01 11 372109 372212 104 + 1.865 1.787 -0.265
ENSG00000182272 E005 78.506092 0.0006526322 2.875570e-01 4.280581e-01 11 372662 372754 93 + 1.883 1.843 -0.134
ENSG00000182272 E006 4.171833 0.0040970601 3.105785e-03 1.057727e-02 11 372755 372807 53 + 0.911 0.497 -1.739
ENSG00000182272 E007 85.614515 0.0007048752 3.445210e-01 4.886133e-01 11 372852 372947 96 + 1.915 1.882 -0.111
ENSG00000182272 E008 94.795901 0.0005602797 1.625719e-01 2.785015e-01 11 373026 373116 91 + 1.970 1.922 -0.163
ENSG00000182272 E009 94.474679 0.0011752108 9.713408e-01 9.860974e-01 11 373191 373291 101 + 1.936 1.940 0.016
ENSG00000182272 E010 89.619433 0.0003771677 9.840158e-01 9.940860e-01 11 373449 373516 68 + 1.910 1.916 0.021
ENSG00000182272 E011 88.848008 0.0003948516 1.156000e-01 2.136963e-01 11 373750 373828 79 + 1.953 1.897 -0.189
ENSG00000182272 E012 84.046372 0.0007950264 1.937828e-01 3.185275e-01 11 375461 375527 67 + 1.924 1.876 -0.163
ENSG00000182272 E013 110.158465 0.0003137041 8.842886e-03 2.588911e-02 11 375639 375773 135 + 2.065 1.979 -0.288
ENSG00000182272 E014 12.243207 0.0014967275 3.561181e-02 8.283058e-02 11 375774 375846 73 + 1.209 1.011 -0.712
ENSG00000182272 E015 110.689793 0.0003314025 5.993282e-04 2.530724e-03 11 375847 375956 110 + 2.083 1.969 -0.381
ENSG00000182272 E016 107.379566 0.0002896969 4.120948e-03 1.348082e-02 11 376074 376174 101 + 2.058 1.962 -0.321
ENSG00000182272 E017 86.089725 0.0004039730 7.311411e-02 1.485053e-01 11 376251 376351 101 + 1.945 1.878 -0.223
ENSG00000182272 E018 60.956326 0.0027800032 6.928636e-02 1.421788e-01 11 376421 376796 376 + 1.815 1.725 -0.303
ENSG00000182272 E019 13.174825 0.0042504831 1.217848e-03 4.700751e-03 11 376797 376872 76 + 1.295 0.991 -1.090
ENSG00000182272 E020 25.317312 0.0120446047 3.682056e-01 5.126099e-01 11 376873 376987 115 + 1.429 1.357 -0.249
ENSG00000182272 E021 106.565326 0.0054843532 9.804635e-01 9.917660e-01 11 376988 377327 340 + 1.985 1.994 0.031
ENSG00000182272 E022 136.888614 0.0004265744 4.197519e-02 9.467881e-02 11 379418 379701 284 + 2.043 2.116 0.246
ENSG00000182272 E023 88.361703 0.0003080395 9.677284e-02 1.855431e-01 11 379866 379981 116 + 1.857 1.930 0.245
ENSG00000182272 E024 67.099871 0.0017559175 1.611257e-02 4.298658e-02 11 379982 380019 38 + 1.700 1.827 0.430
ENSG00000182272 E025 6.692088 0.0027403272 3.001414e-01 4.417855e-01 11 380101 380129 29 + 0.934 0.810 -0.475
ENSG00000182272 E026 96.190960 0.0003575154 3.327791e-03 1.122838e-02 11 380130 380202 73 + 1.857 1.979 0.411
ENSG00000182272 E027 165.197529 0.0003619558 4.248348e-04 1.869496e-03 11 380292 380445 154 + 2.100 2.213 0.377
ENSG00000182272 E028 5.182916 0.0074765544 2.326968e-01 3.656503e-01 11 380671 380824 154 + 0.860 0.702 -0.630
ENSG00000182272 E029 159.841507 0.0053233867 3.758146e-03 1.246292e-02 11 380825 380951 127 + 2.065 2.207 0.476
ENSG00000182272 E030 17.208824 0.0201458375 7.862627e-01 8.631011e-01 11 381084 381158 75 + 1.232 1.217 -0.052
ENSG00000182272 E031 9.474711 0.0789045513 4.043166e-01 5.480265e-01 11 381159 381194 36 + 1.052 0.950 -0.379
ENSG00000182272 E032 193.765087 0.0021837746 2.155792e-07 2.053231e-06 11 381669 382117 449 + 2.111 2.301 0.636