ENSG00000182240

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328735 ENSG00000182240 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE2 protein_coding protein_coding 23.84152 39.26139 18.21391 2.267758 0.3611746 -1.107646 3.0745254 4.6239206 2.579670 0.69861136 0.09735542 -0.8394653 0.12406667 0.1166000 0.14193333 0.02533333 5.043598e-01 1.199743e-19 FALSE  
ENST00000330333 ENSG00000182240 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE2 protein_coding protein_coding 23.84152 39.26139 18.21391 2.267758 0.3611746 -1.107646 0.8410592 0.3397414 1.703239 0.03957167 0.10300223 2.2923659 0.04569583 0.0088000 0.09346667 0.08466667 1.199743e-19 1.199743e-19 FALSE  
ENST00000465326 ENSG00000182240 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE2 protein_coding processed_transcript 23.84152 39.26139 18.21391 2.267758 0.3611746 -1.107646 9.5978053 14.0257584 8.540228 2.22876488 0.56069135 -0.7150722 0.42217917 0.3541000 0.46806667 0.11396667 2.410310e-01 1.199743e-19 FALSE  
ENST00000466122 ENSG00000182240 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE2 protein_coding processed_transcript 23.84152 39.26139 18.21391 2.267758 0.3611746 -1.107646 2.1855748 5.3685132 0.000000 3.19370592 0.00000000 -9.0710636 0.07284167 0.1470333 0.00000000 -0.14703333 2.308681e-01 1.199743e-19 FALSE  
ENST00000487994 ENSG00000182240 HEK293_OSMI2_2hA HEK293_TMG_2hB BACE2 protein_coding processed_transcript 23.84152 39.26139 18.21391 2.267758 0.3611746 -1.107646 6.7148706 11.4394677 4.586733 1.40107878 0.38137655 -1.3165998 0.28402083 0.2892333 0.25200000 -0.03723333 6.660395e-01 1.199743e-19 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182240 E001 6.7088418 0.0035086453 1.324470e-05 8.552626e-05 21 41167801 41168159 359 + 1.136 0.619 -2.003
ENSG00000182240 E002 10.2194507 0.0402940162 1.781474e-07 1.724553e-06 21 41168160 41168200 41 + 1.372 0.669 -2.619
ENSG00000182240 E003 10.0710558 0.0139033256 3.652220e-09 4.877359e-08 21 41168201 41168213 13 + 1.354 0.686 -2.486
ENSG00000182240 E004 111.8145622 0.0037625336 1.797202e-06 1.412347e-05 21 41168214 41168575 362 + 2.139 1.940 -0.666
ENSG00000182240 E005 1.9583928 0.0074214596 4.807041e-01 6.189288e-01 21 41225476 41225695 220 + 0.525 0.411 -0.573
ENSG00000182240 E006 94.0636987 0.0003288738 2.618489e-01 3.995705e-01 21 41226266 41226302 37 + 1.955 1.923 -0.108
ENSG00000182240 E007 118.2078442 0.0005121551 9.133176e-01 9.490666e-01 21 41226303 41226354 52 + 2.020 2.036 0.052
ENSG00000182240 E008 0.0000000       21 41230118 41230223 106 +      
ENSG00000182240 E009 0.1482932 0.0414179351 1.000000e+00   21 41236628 41236664 37 + 0.000 0.088 8.691
ENSG00000182240 E010 291.6215757 0.0001756827 2.624474e-02 6.444740e-02 21 41237513 41237729 217 + 2.376 2.437 0.205
ENSG00000182240 E011 0.1482932 0.0414179351 1.000000e+00   21 41241745 41241818 74 + 0.000 0.088 8.691
ENSG00000182240 E012 255.6519137 0.0001829623 3.556961e-01 5.000532e-01 21 41241819 41241939 121 + 2.340 2.374 0.112
ENSG00000182240 E013 117.4599580 0.0002651149 6.215791e-02 1.302729e-01 21 41241940 41241947 8 + 1.973 2.052 0.264
ENSG00000182240 E014 210.8332495 0.0003773782 5.570030e-02 1.191820e-01 21 41243376 41243510 135 + 2.233 2.297 0.213
ENSG00000182240 E015 179.2650251 0.0013017859 4.915667e-03 1.569560e-02 21 41245962 41246063 102 + 2.131 2.236 0.351
ENSG00000182240 E016 1.5467209 0.0091320969 1.476485e-01 2.584957e-01 21 41246064 41246271 208 + 0.167 0.448 1.941
ENSG00000182240 E017 239.4518685 0.0002536725 2.026405e-03 7.308620e-03 21 41250752 41250901 150 + 2.268 2.358 0.301
ENSG00000182240 E018 0.1515154 0.0428375275 2.302043e-01   21 41252465 41252524 60 + 0.167 0.000 -11.198
ENSG00000182240 E019 254.5578410 0.0003987707 1.598597e-04 7.912461e-04 21 41257158 41257326 169 + 2.280 2.388 0.359
ENSG00000182240 E020 703.2833893 0.0029059157 2.090105e-09 2.915145e-08 21 41275371 41276744 1374 + 2.684 2.844 0.533
ENSG00000182240 E021 75.6849204 0.0009481876 1.015369e-100 3.205978e-97 21 41276745 41279693 2949 + 2.275 1.350 -3.129
ENSG00000182240 E022 85.4758831 0.0022535068 1.120827e-40 4.059986e-38 21 41279694 41282530 2837 + 2.215 1.650 -1.900