ENSG00000182208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329957 ENSG00000182208 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB2 protein_coding protein_coding 41.91106 74.7765 24.63207 6.607605 0.451269 -1.601654 18.197206 35.730778 8.783970 1.5069074 0.1073737 -2.0229846 0.40250417 0.48180000 0.35690000 -0.12490000 0.005253747 0.005253747 FALSE TRUE
ENST00000526462 ENSG00000182208 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB2 protein_coding processed_transcript 41.91106 74.7765 24.63207 6.607605 0.451269 -1.601654 16.806442 28.884709 11.945621 3.8427226 0.6790963 -1.2731163 0.41977083 0.38336667 0.48430000 0.10093333 0.049816237 0.005253747 FALSE FALSE
ENST00000526698 ENSG00000182208 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB2 protein_coding retained_intron 41.91106 74.7765 24.63207 6.607605 0.451269 -1.601654 2.239382 2.453021 1.985163 0.6179442 0.2866300 -0.3039224 0.06517917 0.03190000 0.08103333 0.04913333 0.008850985 0.005253747 TRUE FALSE
MSTRG.4942.4 ENSG00000182208 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB2 protein_coding   41.91106 74.7765 24.63207 6.607605 0.451269 -1.601654 3.432063 6.451084 1.351144 0.9040973 0.1434920 -2.2469567 0.07970000 0.08556667 0.05473333 -0.03083333 0.034035702 0.005253747 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182208 E001 16.4423700 0.0087710797 8.482979e-01 9.057924e-01 11 1469457 1469481 25 - 1.116 1.141 0.090
ENSG00000182208 E002 225.7997653 0.0021698088 8.077936e-03 2.397751e-02 11 1469482 1469673 192 - 2.155 2.257 0.338
ENSG00000182208 E003 160.3077897 0.0045086759 2.978997e-02 7.155144e-02 11 1469674 1469703 30 - 2.002 2.110 0.363
ENSG00000182208 E004 654.2725768 0.0002115229 2.196045e-07 2.088630e-06 11 1469704 1470244 541 - 2.622 2.713 0.304
ENSG00000182208 E005 105.5650801 0.0052823845 4.396265e-01 5.813795e-01 11 1470245 1470270 26 - 1.941 1.901 -0.134
ENSG00000182208 E006 476.8967581 0.0006581007 9.070823e-01 9.450053e-01 11 1470271 1470484 214 - 2.556 2.561 0.014
ENSG00000182208 E007 199.3833136 0.0002054753 6.434553e-02 1.339435e-01 11 1470485 1470488 4 - 2.228 2.173 -0.185
ENSG00000182208 E008 230.1284185 0.0002162630 1.612464e-01 2.767120e-01 11 1471295 1471304 10 - 2.276 2.237 -0.131
ENSG00000182208 E009 425.5591701 0.0001674783 7.694293e-01 8.510943e-01 11 1471305 1471419 115 - 2.515 2.509 -0.017
ENSG00000182208 E010 39.1916039 0.0367243872 6.056911e-02 1.275881e-01 11 1471420 1473436 2017 - 1.663 1.444 -0.747
ENSG00000182208 E011 326.8054558 0.0001584355 4.608120e-03 1.484255e-02 11 1480393 1480486 94 - 2.448 2.383 -0.217
ENSG00000182208 E012 15.7523116 0.0021647338 6.301492e-08 6.654767e-07 11 1480487 1480578 92 - 1.461 0.979 -1.711
ENSG00000182208 E013 13.3658722 0.0016546662 1.839712e-04 8.948844e-04 11 1480579 1480664 86 - 1.315 0.947 -1.323
ENSG00000182208 E014 10.0551076 0.0563122113 1.329720e-02 3.661232e-02 11 1480665 1480724 60 - 1.192 0.838 -1.308
ENSG00000182208 E015 251.2745158 0.0002195792 2.390430e-01 3.729973e-01 11 1480725 1480885 161 - 2.307 2.276 -0.104
ENSG00000182208 E016 0.2998086 0.0292033253 3.305131e-01   11 1481220 1481585 366 - 0.213 0.067 -1.928
ENSG00000182208 E017 0.5848540 0.0522975743 5.679012e-01 6.946441e-01 11 1486447 1486779 333 - 0.001 0.177 8.676
ENSG00000182208 E018 4.8584901 0.0046411895 3.915238e-01 5.354409e-01 11 1501077 1501248 172 - 0.783 0.654 -0.534