ENSG00000182173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333213 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding protein_coding 59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 18.186920 30.634250 8.451249 6.5108905 0.2607038 -1.8566738 0.25813333 0.28723333 0.25193333 -0.035300000 0.88229458 0.0002488542 FALSE TRUE
ENST00000545228 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding protein_coding 59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 4.033507 6.421953 2.235617 0.7168696 0.4317084 -1.5181453 0.06791667 0.06036667 0.06630000 0.005933333 0.90977667 0.0002488542 FALSE TRUE
ENST00000579449 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding retained_intron 59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 4.990711 4.570424 2.786794 0.7415623 1.4573586 -0.7117071 0.10691250 0.04290000 0.08413333 0.041233333 1.00000000 0.0002488542 TRUE TRUE
ENST00000583634 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding retained_intron 59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 5.242115 10.997537 3.705300 1.0047094 0.9369682 -1.5669409 0.09335000 0.10363333 0.10870000 0.005066667 1.00000000 0.0002488542   FALSE
MSTRG.15074.1 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding   59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 3.888162 7.454856 1.016095 1.2970359 0.2529706 -2.8629501 0.07228750 0.07046667 0.02966667 -0.040800000 0.08140776 0.0002488542 FALSE TRUE
MSTRG.15074.18 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding   59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 8.154276 23.665478 2.538762 4.5999090 0.2703792 -3.2155249 0.11420833 0.22493333 0.07556667 -0.149366667 0.00350287 0.0002488542 FALSE TRUE
MSTRG.15074.6 ENSG00000182173 HEK293_OSMI2_2hA HEK293_TMG_2hB TSEN54 protein_coding   59.81214 105.9476 33.59118 4.539728 1.476743 -1.656904 5.452130 10.797308 3.546738 2.2539458 0.5180602 -1.6033807 0.08384167 0.10316667 0.10593333 0.002766667 0.96814293 0.0002488542 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182173 E001 1.036165 0.0135289615 5.779862e-01 7.031527e-01 17 75515649 75515704 56 + 0.339 0.234 -0.726
ENSG00000182173 E002 4.713624 0.0035347760 1.066733e-03 4.190116e-03 17 75515944 75516024 81 + 0.995 0.545 -1.826
ENSG00000182173 E003 3.277430 0.0047750370 1.013949e-03 4.006876e-03 17 75516025 75516059 35 + 0.909 0.416 -2.143
ENSG00000182173 E004 7.863537 0.0933198461 1.069431e-02 3.043877e-02 17 75516060 75516184 125 + 1.165 0.739 -1.604
ENSG00000182173 E005 9.167015 0.0072144072 3.834975e-03 1.267821e-02 17 75516185 75516386 202 + 1.165 0.828 -1.249
ENSG00000182173 E006 0.926596 0.0761036476 3.646729e-03 1.214574e-02 17 75516526 75516527 2 + 0.598 0.072 -4.048
ENSG00000182173 E007 3.064618 0.0691790946 1.785850e-03 6.553999e-03 17 75516528 75516535 8 + 0.909 0.354 -2.499
ENSG00000182173 E008 3.209791 0.0508680742 5.334593e-04 2.284874e-03 17 75516536 75516538 3 + 0.940 0.353 -2.616
ENSG00000182173 E009 8.264673 0.0495345341 4.138863e-04 1.827770e-03 17 75516539 75516547 9 + 1.230 0.713 -1.938
ENSG00000182173 E010 10.065308 0.0645053522 1.196710e-03 4.629195e-03 17 75516548 75516551 4 + 1.286 0.800 -1.786
ENSG00000182173 E011 18.135787 0.0214221526 1.437640e-03 5.431707e-03 17 75516552 75516560 9 + 1.432 1.093 -1.193
ENSG00000182173 E012 60.090643 0.0209030176 1.903021e-02 4.940006e-02 17 75516561 75516596 36 + 1.835 1.640 -0.661
ENSG00000182173 E013 70.727731 0.0262688090 7.097274e-02 1.449548e-01 17 75516597 75516616 20 + 1.875 1.722 -0.516
ENSG00000182173 E014 123.554949 0.0110377980 8.718974e-02 1.708842e-01 17 75516746 75516811 66 + 2.075 1.974 -0.338
ENSG00000182173 E015 95.153657 0.0039889303 7.707470e-02 1.548050e-01 17 75516812 75516814 3 + 1.953 1.863 -0.304
ENSG00000182173 E016 196.812570 0.0037736408 5.499007e-01 6.795942e-01 17 75516815 75516910 96 + 2.214 2.191 -0.077
ENSG00000182173 E017 13.550121 0.0185455844 2.313559e-02 5.802875e-02 17 75516911 75516969 59 + 1.273 1.017 -0.918
ENSG00000182173 E018 23.850553 0.0010297151 6.347547e-02 1.324876e-01 17 75516970 75517008 39 + 1.413 1.264 -0.518
ENSG00000182173 E019 150.816202 0.0002822022 3.726136e-01 5.170558e-01 17 75517009 75517014 6 + 2.104 2.072 -0.107
ENSG00000182173 E020 249.297276 0.0012038048 6.674082e-01 7.746483e-01 17 75517015 75517072 58 + 2.307 2.294 -0.043
ENSG00000182173 E021 7.169217 0.0049526412 4.329911e-01 5.754352e-01 17 75517073 75517160 88 + 0.909 0.804 -0.405
ENSG00000182173 E022 369.573179 0.0001355962 9.340991e-01 9.624838e-01 17 75517161 75517244 84 + 2.470 2.468 -0.008
ENSG00000182173 E023 4.124494 0.0051338119 4.427591e-09 5.826171e-08 17 75517245 75517475 231 + 1.128 0.317 -3.534
ENSG00000182173 E024 487.337452 0.0001424404 2.459329e-01 3.811863e-01 17 75517557 75517655 99 + 2.571 2.593 0.074
ENSG00000182173 E025 257.530491 0.0002075286 4.540442e-01 5.947282e-01 17 75518995 75519002 8 + 2.296 2.315 0.066
ENSG00000182173 E026 371.617288 0.0001831530 5.556952e-01 6.845226e-01 17 75519003 75519047 45 + 2.460 2.473 0.043
ENSG00000182173 E027 5.314198 0.0198625592 3.656544e-03 1.217372e-02 17 75519755 75519944 190 + 1.020 0.606 -1.644
ENSG00000182173 E028 8.030792 0.0023969139 3.583190e-04 1.612358e-03 17 75521355 75521408 54 + 1.165 0.752 -1.550
ENSG00000182173 E029 519.997691 0.0002625358 1.101876e-04 5.688086e-04 17 75521409 75521510 102 + 2.552 2.630 0.261
ENSG00000182173 E030 21.285667 0.0010128496 3.496814e-10 5.629341e-09 17 75521511 75521675 165 + 1.590 1.113 -1.661
ENSG00000182173 E031 9.761689 0.0018629362 2.521544e-08 2.882567e-07 17 75521676 75521704 29 + 1.325 0.738 -2.169
ENSG00000182173 E032 841.719517 0.0002489066 2.922622e-16 1.187904e-14 17 75521705 75522006 302 + 2.714 2.849 0.449
ENSG00000182173 E033 838.057681 0.0012450599 1.818550e-09 2.566630e-08 17 75522007 75522333 327 + 2.716 2.848 0.441
ENSG00000182173 E034 99.808605 0.0003837768 1.090696e-18 5.996200e-17 17 75522334 75522521 188 + 2.148 1.810 -1.136
ENSG00000182173 E035 29.286920 0.0233329041 5.602844e-08 5.972217e-07 17 75522522 75522535 14 + 1.750 1.218 -1.831
ENSG00000182173 E036 81.767401 0.0067788732 2.456508e-20 1.631760e-18 17 75522536 75522899 364 + 2.172 1.658 -1.729
ENSG00000182173 E037 63.509786 0.0024811510 5.305764e-17 2.356767e-15 17 75522900 75523151 252 + 2.014 1.588 -1.439
ENSG00000182173 E038 43.894605 0.0288898329 5.751989e-06 4.038757e-05 17 75523152 75523249 98 + 1.868 1.431 -1.484
ENSG00000182173 E039 30.843210 0.0460913567 1.199085e-04 6.135398e-04 17 75523250 75523274 25 + 1.729 1.278 -1.551
ENSG00000182173 E040 304.598061 0.0020925805 1.590406e-01 2.738422e-01 17 75523275 75523335 61 + 2.351 2.398 0.157
ENSG00000182173 E041 54.957837 0.0082855281 2.040561e-03 7.352608e-03 17 75523336 75523662 327 + 1.813 1.605 -0.702
ENSG00000182173 E042 534.953276 0.0008987310 7.630593e-02 1.535904e-01 17 75523663 75523779 117 + 2.598 2.639 0.138
ENSG00000182173 E043 1113.209316 0.0020728325 4.701495e-03 1.509973e-02 17 75524262 75524794 533 + 2.895 2.962 0.224