ENSG00000182165

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432193 ENSG00000182165 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53TG1 lncRNA lncRNA 22.42325 41.0967 9.397123 3.366861 0.555114 -2.127548 3.320413 5.291704 1.344194 0.8002078 0.1334232 -1.969022 0.1499625 0.1305000 0.1430333 0.01253333 8.674860e-01 4.296016e-21   FALSE
ENST00000685722 ENSG00000182165 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53TG1 lncRNA lncRNA 22.42325 41.0967 9.397123 3.366861 0.555114 -2.127548 3.003332 6.612925 0.000000 0.9269386 0.0000000 -9.371325 0.1180833 0.1610000 0.0000000 -0.16100000 4.296016e-21 4.296016e-21   FALSE
ENST00000690980 ENSG00000182165 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53TG1 lncRNA lncRNA 22.42325 41.0967 9.397123 3.366861 0.555114 -2.127548 4.493283 7.563750 3.326699 1.1558219 0.4307307 -1.182586 0.2118542 0.1826667 0.3582667 0.17560000 3.075992e-02 4.296016e-21   FALSE
MSTRG.30169.6 ENSG00000182165 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53TG1 lncRNA   22.42325 41.0967 9.397123 3.366861 0.555114 -2.127548 6.029545 12.468791 1.942844 1.5898137 0.5328528 -2.675830 0.2575125 0.3009333 0.2018333 -0.09910000 2.346303e-01 4.296016e-21   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182165 E001 0.2966881 0.0277167186 1.740738e-02   7 87322943 87324586 1644 - 0.375 0.000 -12.167
ENSG00000182165 E002 0.0000000       7 87324587 87324589 3 -      
ENSG00000182165 E003 4.4048342 0.0059716596 2.290123e-08 2.640505e-07 7 87324590 87325114 525 - 1.146 0.379 -3.224
ENSG00000182165 E004 2.0628691 0.0324559250 1.692839e-04 8.321092e-04 7 87325115 87325136 22 - 0.855 0.209 -3.313
ENSG00000182165 E005 5.6411505 0.0029178614 2.959123e-06 2.216762e-05 7 87325137 87325345 209 - 1.146 0.541 -2.393
ENSG00000182165 E006 2.9526399 0.0053647536 4.675505e-02 1.033885e-01 7 87325346 87325346 1 - 0.763 0.432 -1.494
ENSG00000182165 E007 4.7572505 0.0034840038 4.556044e-01 5.961205e-01 7 87325347 87325351 5 - 0.763 0.643 -0.495
ENSG00000182165 E008 88.0604784 0.0005295138 6.646523e-02 1.374963e-01 7 87325352 87325444 93 - 1.746 1.834 0.296
ENSG00000182165 E009 3.7932952 0.0048655748 6.904927e-02 1.418014e-01 7 87326263 87326449 187 - 0.811 0.521 -1.239
ENSG00000182165 E010 3.2053923 0.0415125370 4.081107e-01 5.516889e-01 7 87329935 87330031 97 - 0.646 0.481 -0.754
ENSG00000182165 E011 3.5385103 0.0139221044 8.897560e-01 9.335335e-01 7 87330032 87330094 63 - 0.573 0.542 -0.143
ENSG00000182165 E012 1.7174575 0.0111967536 2.766361e-07 2.578367e-06 7 87339149 87341354 2206 - 0.895 0.063 -5.466
ENSG00000182165 E013 0.6976476 0.1036194766 1.919279e-01 3.161863e-01 7 87341355 87341401 47 - 0.374 0.118 -2.132
ENSG00000182165 E014 0.8491631 0.0163643812 4.344885e-02 9.737557e-02 7 87341402 87341469 68 - 0.485 0.117 -2.728
ENSG00000182165 E015 1.1155605 0.0130265361 2.501780e-02 6.190875e-02 7 87341470 87341522 53 - 0.573 0.166 -2.561
ENSG00000182165 E016 168.3087667 0.0003278183 1.613322e-01 2.768179e-01 7 87341523 87341637 115 - 2.062 2.106 0.147
ENSG00000182165 E017 118.0316750 0.0003352600 3.201118e-01 4.632286e-01 7 87341638 87341652 15 - 1.916 1.954 0.126
ENSG00000182165 E018 149.2488675 0.0006915378 8.563119e-01 9.111511e-01 7 87341653 87341684 32 - 2.046 2.048 0.007
ENSG00000182165 E019 3.3633496 0.2019706873 8.426584e-01 9.019566e-01 7 87344776 87345042 267 - 0.574 0.515 -0.274
ENSG00000182165 E020 171.3810133 0.0003296796 8.193825e-01 8.859527e-01 7 87345043 87345199 157 - 2.117 2.106 -0.038
ENSG00000182165 E021 92.6028530 0.0056977376 8.517788e-01 9.080966e-01 7 87345200 87345233 34 - 1.855 1.838 -0.055
ENSG00000182165 E022 109.5551605 0.0020830504 6.671992e-01 7.745125e-01 7 87345234 87345304 71 - 1.902 1.917 0.053
ENSG00000182165 E023 185.1018839 0.0003456041 1.866609e-01 3.095444e-01 7 87345305 87345552 248 - 2.106 2.144 0.129