ENSG00000182150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000456993 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding nonsense_mediated_decay 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.2046967 0.22694823 0.07069515 0.139811639 0.07069515 -1.5540180 0.07818333 0.12790000 0.009966667 -0.11793333 3.026942e-01 3.205507e-10 FALSE TRUE
ENST00000653738 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding protein_coding 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.6955444 0.09733507 0.50897886 0.097335072 0.50897886 2.2735542 0.13160000 0.05476667 0.064466667 0.00970000 8.800285e-01 3.205507e-10 FALSE TRUE
ENST00000665077 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding protein_coding 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.2509148 0.16622089 0.60724669 0.166220888 0.03090342 1.8084623 0.05331667 0.09410000 0.082066667 -0.01203333 6.701531e-01 3.205507e-10 FALSE TRUE
ENST00000668220 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding protein_coding 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.4975322 0.00000000 0.96007497 0.000000000 0.24434026 6.6000243 0.07917500 0.00000000 0.128433333 0.12843333 2.133091e-04 3.205507e-10 FALSE TRUE
ENST00000682148 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding retained_intron 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.1973631 0.08023081 0.23282435 0.034012847 0.03147119 1.4282211 0.05508333 0.04393333 0.031366667 -0.01256667 9.021081e-01 3.205507e-10 TRUE FALSE
ENST00000682983 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding nonsense_mediated_decay 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.3506766 0.00000000 0.54330242 0.000000000 0.27804870 5.7899963 0.05421667 0.00000000 0.076166667 0.07616667 4.206546e-01 3.205507e-10 TRUE TRUE
ENST00000683128 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding nonsense_mediated_decay 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.1714070 0.34612846 0.03999770 0.176142734 0.02008646 -2.8324640 0.08892083 0.18863333 0.005600000 -0.18303333 8.900094e-02 3.205507e-10 TRUE TRUE
ENST00000683230 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding processed_transcript 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.1506191 0.23554453 0.00000000 0.119599082 0.00000000 -4.6179128 0.05697083 0.12786667 0.000000000 -0.12786667 5.052597e-02 3.205507e-10 FALSE TRUE
ENST00000683937 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding protein_coding 4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.1508329 0.15019404 0.97582885 0.150194040 0.48814738 2.6215167 0.03369583 0.07786667 0.136633333 0.05876667 7.210407e-01 3.205507e-10 FALSE TRUE
MSTRG.33064.11 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding   4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.6346924 0.00000000 1.59300426 0.000000000 0.15881860 7.3246345 0.08938750 0.00000000 0.214866667 0.21486667 3.205507e-10 3.205507e-10 FALSE TRUE
MSTRG.33064.27 ENSG00000182150 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC6L2 protein_coding   4.581604 1.824142 7.392354 0.05236192 0.2523195 2.012879 0.1677796 0.24886112 0.22778419 0.004516856 0.22778419 -0.1225255 0.06090833 0.13676667 0.028866667 -0.10790000 1.208507e-01 3.205507e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182150 E001 0.0000000       9 95871264 95871269 6 +      
ENSG00000182150 E002 0.0000000       9 95874985 95875058 74 +      
ENSG00000182150 E003 0.0000000       9 95875059 95875124 66 +      
ENSG00000182150 E004 0.0000000       9 95875125 95875132 8 +      
ENSG00000182150 E005 0.5963950 0.4136306675 1.040730e-01 1.967107e-01 9 95875233 95875617 385 + 0.067 0.450 3.446
ENSG00000182150 E006 0.2924217 0.0290785164 1.000000e+00   9 95875618 95875649 32 + 0.125 0.000 -10.707
ENSG00000182150 E007 0.2924217 0.0290785164 1.000000e+00   9 95875650 95875655 6 + 0.125 0.000 -10.707
ENSG00000182150 E008 0.4439371 0.0215781326 5.727826e-01 6.988462e-01 9 95875656 95875660 5 + 0.176 0.000 -11.301
ENSG00000182150 E009 1.9887747 0.0074226701 2.012703e-01 3.277797e-01 9 95875661 95875676 16 + 0.476 0.214 -1.645
ENSG00000182150 E010 3.2390005 0.0076940627 1.737570e-01 2.930678e-01 9 95875677 95875683 7 + 0.619 0.357 -1.307
ENSG00000182150 E011 3.8343513 0.0041740417 5.521191e-01 6.814512e-01 9 95875684 95875690 7 + 0.652 0.550 -0.453
ENSG00000182150 E012 4.5643674 0.0082838843 3.051576e-01 4.472024e-01 9 95875691 95875701 11 + 0.726 0.550 -0.760
ENSG00000182150 E013 7.9610132 0.0179245214 4.030747e-02 9.159875e-02 9 95875702 95875712 11 + 0.953 0.622 -1.323
ENSG00000182150 E014 13.5826380 0.0361170839 9.852045e-02 1.882365e-01 9 95875713 95875762 50 + 1.145 0.905 -0.879
ENSG00000182150 E015 25.5388925 0.0350539897 9.275708e-02 1.794307e-01 9 95875763 95876005 243 + 1.399 1.194 -0.716
ENSG00000182150 E016 13.0760839 0.0082578081 1.119095e-01 2.083772e-01 9 95876006 95876046 41 + 1.129 0.936 -0.708
ENSG00000182150 E017 11.3391588 0.0015541190 1.800464e-01 3.012307e-01 9 95876047 95876084 38 + 1.066 0.904 -0.602
ENSG00000182150 E018 4.0901726 0.0117308709 8.817826e-04 3.550425e-03 9 95876143 95877105 963 + 0.476 0.968 2.054
ENSG00000182150 E019 47.3791427 0.0005080659 7.656328e-02 1.539926e-01 9 95880869 95881293 425 + 1.642 1.533 -0.372
ENSG00000182150 E020 31.2640183 0.0235351014 4.265420e-07 3.825550e-06 9 95881294 95883331 2038 + 1.274 1.759 1.664
ENSG00000182150 E021 19.4973763 0.0281012114 2.143696e-02 5.450865e-02 9 95897849 95897971 123 + 1.304 0.995 -1.107
ENSG00000182150 E022 0.0000000       9 95906588 95906710 123 +      
ENSG00000182150 E023 10.4395200 0.0113558864 2.379435e-01 3.717427e-01 9 95907078 95907122 45 + 1.027 0.868 -0.596
ENSG00000182150 E024 19.2028663 0.0235738583 5.776728e-03 1.802523e-02 9 95907123 95907271 149 + 1.304 0.937 -1.324
ENSG00000182150 E025 25.7727710 0.0099248800 3.679979e-03 1.223863e-02 9 95915668 95915829 162 + 1.417 1.117 -1.053
ENSG00000182150 E026 34.1105944 0.0041021852 1.220462e-03 4.709881e-03 9 95916227 95916434 208 + 1.530 1.260 -0.936
ENSG00000182150 E027 22.4361749 0.0008469183 7.181035e-05 3.890154e-04 9 95921175 95921315 141 + 1.373 0.968 -1.448
ENSG00000182150 E028 17.2318551 0.0273568337 2.352259e-02 5.882649e-02 9 95922305 95922418 114 + 1.250 0.940 -1.122
ENSG00000182150 E029 18.7703580 0.0459646906 1.184422e-01 2.177101e-01 9 95923260 95923379 120 + 1.273 1.053 -0.783
ENSG00000182150 E030 14.4337549 0.0141993854 1.795727e-02 4.704351e-02 9 95928079 95928150 72 + 1.179 0.869 -1.142
ENSG00000182150 E031 0.1451727 0.0425828632 1.000000e+00   9 95928151 95928277 127 + 0.067 0.000 -9.667
ENSG00000182150 E032 23.8526443 0.0172355036 1.974513e-01 3.230357e-01 9 95928719 95928864 146 + 1.354 1.216 -0.482
ENSG00000182150 E033 0.5212538 0.0212740770 8.760037e-02 1.714991e-01 9 95928865 95929117 253 + 0.067 0.357 2.939
ENSG00000182150 E034 22.9422250 0.0008120567 5.085518e-03 1.616314e-02 9 95941454 95941549 96 + 1.361 1.096 -0.935
ENSG00000182150 E035 0.1472490 0.0428245298 1.000000e+00   9 95941550 95942518 969 + 0.067 0.000 -9.666
ENSG00000182150 E036 0.7665478 0.0184090557 1.000000e+00 1.000000e+00 9 95954728 95954922 195 + 0.221 0.214 -0.060
ENSG00000182150 E037 23.6053181 0.0007904864 2.818393e-03 9.728646e-03 9 95955914 95956013 100 + 1.376 1.096 -0.989
ENSG00000182150 E038 28.9595399 0.0006415156 6.626127e-03 2.025494e-02 9 95966562 95966714 153 + 1.454 1.229 -0.783
ENSG00000182150 E039 1.1103636 0.0115578059 6.255136e-01 7.416181e-01 9 95966715 95967318 604 + 0.263 0.357 0.617
ENSG00000182150 E040 0.1451727 0.0425828632 1.000000e+00   9 95967319 95967458 140 + 0.067 0.000 -9.667
ENSG00000182150 E041 2.1747455 0.0075481845 5.405415e-01 6.716776e-01 9 95967459 95967625 167 + 0.476 0.357 -0.645
ENSG00000182150 E042 0.3268771 0.0285734290 3.276815e-01   9 95967626 95968840 1215 + 0.067 0.214 1.940
ENSG00000182150 E043 0.0000000       9 95970391 95970575 185 +      
ENSG00000182150 E044 23.9340039 0.0009118638 3.371969e-02 7.919486e-02 9 95970576 95970656 81 + 1.367 1.177 -0.667
ENSG00000182150 E045 0.5889961 0.9276525175 1.000000e+00 1.000000e+00 9 95970657 95971543 887 + 0.221 0.000 -10.549
ENSG00000182150 E046 0.1451727 0.0425828632 1.000000e+00   9 95971544 95971595 52 + 0.067 0.000 -9.667
ENSG00000182150 E047 0.0000000       9 95971596 95971932 337 +      
ENSG00000182150 E048 28.3924652 0.0261210660 7.433058e-03 2.234435e-02 9 95971933 95972086 154 + 1.458 1.142 -1.107
ENSG00000182150 E049 27.8751496 0.0768925538 6.274635e-02 1.312782e-01 9 95972087 95972281 195 + 1.443 1.171 -0.949
ENSG00000182150 E050 77.5600097 0.0006396173 9.400832e-05 4.937919e-04 9 95972282 95973088 807 + 1.865 1.665 -0.675
ENSG00000182150 E051 16.0795959 0.0010890857 4.504175e-02 1.002782e-01 9 95978061 95978077 17 + 1.212 0.997 -0.777
ENSG00000182150 E052 27.5225332 0.0007254377 1.344690e-01 2.403697e-01 9 95978078 95978215 138 + 1.411 1.290 -0.421
ENSG00000182150 E053 4.4154340 0.0046594916 3.388274e-01 4.827258e-01 9 95978216 95979714 1499 + 0.712 0.550 -0.705
ENSG00000182150 E054 8.0315797 0.0166748079 4.605604e-02 1.021397e-01 9 95979715 95981064 1350 + 0.812 1.074 0.984
ENSG00000182150 E055 0.9244034 0.0141668469 4.951074e-03 1.579466e-02 9 95981561 95981619 59 + 0.067 0.551 3.941
ENSG00000182150 E056 5.5428821 0.0880732057 1.469255e-01 2.574989e-01 9 95982910 95984665 1756 + 0.683 0.959 1.083
ENSG00000182150 E057 13.1966354 0.0946894601 6.226428e-01 7.394107e-01 9 95994214 95997245 3032 + 1.054 1.169 0.412
ENSG00000182150 E058 2.7700843 0.0055200708 2.839765e-01 4.241814e-01 9 95997246 95997413 168 + 0.563 0.357 -1.060
ENSG00000182150 E059 26.9270687 0.0007388475 8.033254e-02 1.600795e-01 9 96004520 96004701 182 + 1.405 1.260 -0.505
ENSG00000182150 E060 1.0371996 0.0254067879 1.492037e-01 2.605746e-01 9 96004702 96005415 714 + 0.335 0.000 -12.363
ENSG00000182150 E061 99.2200568 0.0038637237 7.371096e-01 8.273730e-01 9 96012225 96013647 1423 + 1.932 1.919 -0.044
ENSG00000182150 E062 202.1840349 0.0002515623 1.768323e-53 1.311913e-50 9 96013648 96018447 4800 + 2.118 2.487 1.234
ENSG00000182150 E063 7.8831993 0.0357008797 6.978847e-02 1.430217e-01 9 96038876 96039127 252 + 0.812 1.072 0.976
ENSG00000182150 E064 23.5249649 0.0179404950 6.446950e-06 4.476124e-05 9 96039128 96040580 1453 + 1.180 1.611 1.494
ENSG00000182150 E065 0.0000000       9 96120367 96121154 788 +