ENSG00000182134

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368824 ENSG00000182134 HEK293_OSMI2_2hA HEK293_TMG_2hB TDRKH protein_coding protein_coding 9.938326 10.77234 8.246828 1.041178 0.3807439 -0.3850112 0.9731792 0.6807157 1.0670431 0.68071574 1.0670431 0.6409120 0.09544583 0.06070000 0.12310000 0.0624000000 1.0000000000 0.0002443977 FALSE TRUE
ENST00000368827 ENSG00000182134 HEK293_OSMI2_2hA HEK293_TMG_2hB TDRKH protein_coding protein_coding 9.938326 10.77234 8.246828 1.041178 0.3807439 -0.3850112 0.5023584 0.4730817 0.3622833 0.05561537 0.0762104 -0.3758664 0.05038333 0.04376667 0.04423333 0.0004666667 1.0000000000 0.0002443977 FALSE TRUE
ENST00000458431 ENSG00000182134 HEK293_OSMI2_2hA HEK293_TMG_2hB TDRKH protein_coding protein_coding 9.938326 10.77234 8.246828 1.041178 0.3807439 -0.3850112 3.5857890 3.7835831 2.6788347 0.68116970 0.8292390 -0.4965801 0.36273333 0.35446667 0.33143333 -0.0230333333 0.9314049192 0.0002443977 FALSE TRUE
ENST00000525790 ENSG00000182134 HEK293_OSMI2_2hA HEK293_TMG_2hB TDRKH protein_coding nonsense_mediated_decay 9.938326 10.77234 8.246828 1.041178 0.3807439 -0.3850112 2.6077537 4.0671174 1.5830156 0.47115379 0.1338124 -1.3557891 0.26081250 0.37906667 0.19153333 -0.1875333333 0.0002443977 0.0002443977 FALSE TRUE
MSTRG.2235.12 ENSG00000182134 HEK293_OSMI2_2hA HEK293_TMG_2hB TDRKH protein_coding   9.938326 10.77234 8.246828 1.041178 0.3807439 -0.3850112 0.3329170 0.2932812 0.8344809 0.17046165 0.4562090 1.4774086 0.03702917 0.02540000 0.10250000 0.0771000000 0.7680378387 0.0002443977 FALSE TRUE
MSTRG.2235.4 ENSG00000182134 HEK293_OSMI2_2hA HEK293_TMG_2hB TDRKH protein_coding   9.938326 10.77234 8.246828 1.041178 0.3807439 -0.3850112 0.6814838 0.0000000 0.8336231 0.00000000 0.4171397 6.3985267 0.06816667 0.00000000 0.10406667 0.1040666667 0.1659443739 0.0002443977 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182134 E001 20.7086086 0.0009630746 0.0005867762 0.002484867 1 151770107 151770172 66 - 1.114 1.400 1.008
ENSG00000182134 E002 15.4426774 0.0022314981 0.0106354840 0.030297889 1 151770173 151770173 1 - 1.025 1.267 0.867
ENSG00000182134 E003 32.9722087 0.0170608073 0.0100226687 0.028818938 1 151770174 151770257 84 - 1.353 1.577 0.771
ENSG00000182134 E004 59.8813688 0.0057172253 0.0059208953 0.018400221 1 151770258 151770562 305 - 1.653 1.814 0.544
ENSG00000182134 E005 5.7120463 0.0029447427 0.3782190652 0.522502071 1 151771564 151771919 356 - 0.732 0.851 0.471
ENSG00000182134 E006 4.5540658 0.0362009349 0.7758350127 0.855624580 1 151771920 151771986 67 - 0.699 0.741 0.171
ENSG00000182134 E007 1.6521528 0.0086971229 0.1877034545 0.310846057 1 151773479 151773491 13 - 0.255 0.494 1.406
ENSG00000182134 E008 1.2490032 0.0134408999 0.3925291608 0.536494278 1 151773492 151773493 2 - 0.255 0.413 0.988
ENSG00000182134 E009 1.3972964 0.0358465623 0.3023402352 0.444207806 1 151773494 151773497 4 - 0.255 0.453 1.202
ENSG00000182134 E010 61.7615492 0.0186499795 0.1785606831 0.299350339 1 151773498 151773925 428 - 1.707 1.821 0.385
ENSG00000182134 E011 41.4557895 0.0054583913 0.8074532658 0.877665901 1 151773926 151773997 72 - 1.604 1.623 0.066
ENSG00000182134 E012 51.4044733 0.0098126909 0.4799966871 0.618334188 1 151773998 151774098 101 - 1.672 1.722 0.168
ENSG00000182134 E013 49.0340165 0.0066225769 0.8390867223 0.899435850 1 151774099 151774227 129 - 1.693 1.682 -0.040
ENSG00000182134 E014 43.1319538 0.0004865424 0.8873195000 0.931995080 1 151774228 151774412 185 - 1.625 1.635 0.033
ENSG00000182134 E015 74.8918346 0.0050933831 0.8861102809 0.931178034 1 151774413 151774504 92 - 1.858 1.868 0.033
ENSG00000182134 E016 82.3926123 0.0030698850 0.4912985543 0.628588081 1 151774710 151774806 97 - 1.884 1.918 0.114
ENSG00000182134 E017 83.9917435 0.0060639547 0.8120388064 0.880752035 1 151775065 151775166 102 - 1.921 1.911 -0.035
ENSG00000182134 E018 103.8646589 0.0003315794 0.5150014770 0.649722612 1 151775392 151775543 152 - 1.988 2.013 0.083
ENSG00000182134 E019 63.2361337 0.0003694158 0.3021259683 0.443982239 1 151775820 151775884 65 - 1.762 1.810 0.164
ENSG00000182134 E020 100.2859590 0.0003252269 0.8559913948 0.910977922 1 151776096 151776268 173 - 1.995 1.991 -0.015
ENSG00000182134 E021 80.4034973 0.0003768563 0.7619146153 0.845655929 1 151776439 151776599 161 - 1.904 1.894 -0.033
ENSG00000182134 E022 0.4741261 0.0212726249 0.3552649639 0.499629904 1 151778633 151778684 52 - 0.255 0.102 -1.592
ENSG00000182134 E023 112.1634244 0.0002805604 0.7719278542 0.852812392 1 151778685 151779006 322 - 2.032 2.044 0.039
ENSG00000182134 E024 62.0748829 0.0050176036 0.0892688335 0.174026168 1 151779103 151779207 105 - 1.843 1.749 -0.318
ENSG00000182134 E025 34.4874315 0.0042686416 0.0822846304 0.163116728 1 151779208 151779242 35 - 1.604 1.490 -0.389
ENSG00000182134 E026 0.4449813 0.0212906432 0.3546776791 0.499009463 1 151779743 151779950 208 - 0.255 0.102 -1.595
ENSG00000182134 E027 32.5292512 0.0014920876 0.0797672142 0.159194103 1 151779951 151779978 28 - 1.572 1.464 -0.372
ENSG00000182134 E028 27.5011611 0.0041310212 0.0404695470 0.091881096 1 151779979 151779989 11 - 1.523 1.377 -0.504
ENSG00000182134 E029 42.3412012 0.0124193714 0.0702056446 0.143697924 1 151779990 151780050 61 - 1.703 1.563 -0.477
ENSG00000182134 E030 30.6322396 0.0006779307 0.0110174974 0.031202545 1 151780051 151780086 36 - 1.582 1.426 -0.533
ENSG00000182134 E031 40.0547009 0.0005879218 0.0539403911 0.116160202 1 151780087 151780128 42 - 1.660 1.556 -0.356
ENSG00000182134 E032 31.3530651 0.0062100669 0.2034922244 0.330587709 1 151780129 151780140 12 - 1.549 1.456 -0.319
ENSG00000182134 E033 60.0648703 0.0148294168 0.4466524567 0.588132449 1 151781481 151781587 107 - 1.804 1.747 -0.192
ENSG00000182134 E034 0.0000000       1 151781909 151782019 111 -      
ENSG00000182134 E035 0.0000000       1 151782780 151782898 119 -      
ENSG00000182134 E036 60.0488485 0.0120105117 0.4093549556 0.552972450 1 151782899 151783049 151 - 1.802 1.748 -0.180
ENSG00000182134 E037 0.1482932 0.0413805797 0.6954920874   1 151783050 151783188 139 - 0.000 0.102 9.650
ENSG00000182134 E038 0.1472490 0.0454240239 0.3338484395   1 151783624 151783771 148 - 0.146 0.000 -11.113
ENSG00000182134 E039 12.5822797 0.0089351481 0.9284289914 0.958962392 1 151790380 151790398 19 - 1.127 1.119 -0.027
ENSG00000182134 E040 15.5932342 0.0179967921 0.7996179819 0.872198776 1 151790399 151790404 6 - 1.187 1.219 0.112
ENSG00000182134 E041 24.0860848 0.0212269052 0.8575305061 0.912025892 1 151790405 151790522 118 - 1.391 1.376 -0.051
ENSG00000182134 E042 0.0000000       1 151790810 151791416 607 -