ENSG00000182095

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328270 ENSG00000182095 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC18 protein_coding protein_coding 18.30287 24.72949 14.12016 2.150778 0.6206369 -0.8080379 3.0195392 4.596718 1.7051704 0.2926753 0.32541256 -1.4253874 0.1567875 0.1868000 0.1195333 -0.06726667 1.308124e-01 1.24861e-14 FALSE FALSE
ENST00000430969 ENSG00000182095 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC18 protein_coding protein_coding 18.30287 24.72949 14.12016 2.150778 0.6206369 -0.8080379 5.3740058 6.477642 4.0306062 1.1460768 0.27120162 -0.6831225 0.2913792 0.2577333 0.2871667 0.02943333 7.998214e-01 1.24861e-14 FALSE TRUE
ENST00000440081 ENSG00000182095 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC18 protein_coding protein_coding 18.30287 24.72949 14.12016 2.150778 0.6206369 -0.8080379 5.6195474 7.595425 5.2972747 0.4064986 0.31905052 -0.5190576 0.3155083 0.3093333 0.3749667 0.06563333 1.696885e-01 1.24861e-14 FALSE FALSE
MSTRG.29435.1 ENSG00000182095 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC18 protein_coding   18.30287 24.72949 14.12016 2.150778 0.6206369 -0.8080379 1.5484608 4.022533 0.1862818 0.1299141 0.09326909 -4.3606880 0.0759625 0.1660000 0.0131000 -0.15290000 4.416296e-04 1.24861e-14 FALSE TRUE
MSTRG.29435.5 ENSG00000182095 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC18 protein_coding   18.30287 24.72949 14.12016 2.150778 0.6206369 -0.8080379 0.5780646 0.000000 1.3907210 0.0000000 0.28026220 7.1300259 0.0385875 0.0000000 0.0991000 0.09910000 1.248610e-14 1.24861e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182095 E001 0.3299976 0.0258445334 4.724649e-01   7 5306294 5306638 345 - 0.000 0.162 9.228
ENSG00000182095 E002 0.0000000       7 5306639 5306789 151 -      
ENSG00000182095 E003 3.9061698 0.0129242072 1.135213e-04 5.839970e-04 7 5306790 5306810 21 - 0.000 0.762 13.746
ENSG00000182095 E004 123.3600003 0.0146018250 2.355206e-08 2.707607e-07 7 5306811 5307299 489 - 1.730 2.134 1.359
ENSG00000182095 E005 310.7117264 0.0099407948 5.457425e-05 3.045878e-04 7 5307300 5307944 645 - 2.284 2.501 0.723
ENSG00000182095 E006 56.1824429 0.0040860148 3.113521e-03 1.059980e-02 7 5307945 5307956 12 - 1.578 1.758 0.611
ENSG00000182095 E007 78.4896911 0.0003985540 1.425606e-04 7.145647e-04 7 5307957 5308007 51 - 1.723 1.894 0.580
ENSG00000182095 E008 53.5259001 0.0004446599 1.325244e-02 3.650611e-02 7 5308008 5308024 17 - 1.589 1.721 0.447
ENSG00000182095 E009 210.8223256 0.0038945859 1.007783e-03 3.985335e-03 7 5308025 5308312 288 - 2.179 2.314 0.452
ENSG00000182095 E010 118.1882739 0.0003058650 1.079289e-04 5.585951e-04 7 5308875 5308949 75 - 1.922 2.063 0.473
ENSG00000182095 E011 207.2427797 0.0039147235 4.721204e-02 1.042105e-01 7 5309132 5309368 237 - 2.214 2.294 0.265
ENSG00000182095 E012 226.1257801 0.0029371906 4.580394e-02 1.016746e-01 7 5312503 5313110 608 - 2.251 2.328 0.255
ENSG00000182095 E013 287.1934855 0.0001948373 1.195057e-02 3.341402e-02 7 5313111 5313859 749 - 2.367 2.423 0.187
ENSG00000182095 E014 50.5139582 0.0008208161 5.804176e-01 7.051694e-01 7 5313860 5313863 4 - 1.691 1.658 -0.112
ENSG00000182095 E015 1.0277444 0.0706106724 1.049566e-01 1.980272e-01 7 5314980 5314983 4 - 0.000 0.333 11.685
ENSG00000182095 E016 128.7615879 0.0009442882 8.367035e-01 8.978682e-01 7 5314984 5315148 165 - 2.064 2.069 0.016
ENSG00000182095 E017 123.1931896 0.0002866523 8.076655e-01 8.777978e-01 7 5315956 5316072 117 - 2.042 2.048 0.018
ENSG00000182095 E018 0.3268771 0.0292066388 6.028981e-01   7 5320140 5320317 178 - 0.166 0.089 -1.040
ENSG00000182095 E019 109.8054218 0.0002615787 6.696838e-01 7.763834e-01 7 5320318 5320426 109 - 2.008 1.989 -0.063
ENSG00000182095 E020 95.1292685 0.0004746701 3.730691e-02 8.604749e-02 7 5320532 5320607 76 - 1.871 1.954 0.278
ENSG00000182095 E021 0.0000000       7 5320608 5320662 55 -      
ENSG00000182095 E022 107.6403709 0.0004680794 1.260764e-02 3.498577e-02 7 5321073 5321190 118 - 1.915 2.009 0.317
ENSG00000182095 E023 55.3475701 0.0055992210 1.906056e-01 3.145250e-01 7 5324214 5324221 8 - 1.643 1.727 0.285
ENSG00000182095 E024 61.1014164 0.0030637622 5.493476e-02 1.178835e-01 7 5324222 5324246 25 - 1.665 1.774 0.367
ENSG00000182095 E025 102.9428894 0.0006063862 4.522128e-01 5.930879e-01 7 5324247 5324355 109 - 1.946 1.973 0.092
ENSG00000182095 E026 96.4478441 0.0053517779 1.037966e-02 2.969400e-02 7 5325096 5325248 153 - 2.028 1.899 -0.431
ENSG00000182095 E027 2.2423914 0.0068713499 4.453352e-02 9.933908e-02 7 5325249 5325574 326 - 0.166 0.544 2.421
ENSG00000182095 E028 10.2454889 0.0376870417 2.784293e-01 4.181174e-01 7 5329937 5329969 33 - 1.118 0.970 -0.541
ENSG00000182095 E029 114.2003229 0.0010551265 2.684178e-04 1.251178e-03 7 5332622 5333049 428 - 2.104 1.967 -0.460
ENSG00000182095 E030 112.9136575 0.0092425143 3.263119e-01 4.697657e-01 7 5345562 5345810 249 - 2.051 1.993 -0.193
ENSG00000182095 E031 169.9421291 0.0044546558 2.410155e-01 3.753672e-01 7 5351819 5352001 183 - 2.152 2.200 0.163
ENSG00000182095 E032 144.3718056 0.0005804572 6.899872e-01 7.917960e-01 7 5352002 5352094 93 - 2.107 2.117 0.035
ENSG00000182095 E033 278.0547593 0.0010035324 2.951342e-01 4.362557e-01 7 5356916 5357276 361 - 2.419 2.390 -0.098
ENSG00000182095 E034 159.4866422 0.0024129923 3.505517e-01 4.947292e-01 7 5359398 5359569 172 - 2.181 2.147 -0.116
ENSG00000182095 E035 89.6612900 0.0011192008 1.202973e-01 2.204037e-01 7 5361594 5361722 129 - 1.857 1.924 0.225
ENSG00000182095 E036 129.9808271 0.0005904583 6.690920e-01 7.759786e-01 7 5361897 5362033 137 - 2.078 2.061 -0.056
ENSG00000182095 E037 134.8361739 0.0003188333 1.331984e-01 2.385836e-01 7 5362650 5362825 176 - 2.044 2.093 0.163
ENSG00000182095 E038 364.1576268 0.0021468342 3.329016e-01 4.765688e-01 7 5370375 5371364 990 - 2.532 2.508 -0.082
ENSG00000182095 E039 77.7525831 0.0003830608 6.773484e-06 4.681050e-05 7 5374055 5374481 427 - 1.975 1.785 -0.639
ENSG00000182095 E040 27.3968181 0.0007515568 3.080881e-02 7.354448e-02 7 5374482 5374484 3 - 1.509 1.358 -0.521
ENSG00000182095 E041 49.8731830 0.0004499344 2.451105e-02 6.087449e-02 7 5376034 5376113 80 - 1.738 1.617 -0.409
ENSG00000182095 E042 72.7337593 0.0021530289 3.727538e-02 8.599152e-02 7 5376114 5376224 111 - 1.889 1.787 -0.346
ENSG00000182095 E043 88.5807718 0.0059092717 9.508825e-02 1.830115e-01 7 5376847 5376993 147 - 1.968 1.876 -0.308
ENSG00000182095 E044 95.3087190 0.0020125736 2.694311e-03 9.356916e-03 7 5377371 5377576 206 - 2.023 1.893 -0.439
ENSG00000182095 E045 85.2863520 0.0136513695 3.819616e-02 8.771977e-02 7 5377922 5378024 103 - 1.978 1.846 -0.445
ENSG00000182095 E046 247.7763325 0.0123642721 5.871708e-05 3.250855e-04 7 5387672 5389304 1633 - 2.490 2.278 -0.709
ENSG00000182095 E047 26.6086289 0.0113723945 5.959651e-03 1.850184e-02 7 5389305 5389336 32 - 1.539 1.312 -0.783
ENSG00000182095 E048 0.9566712 0.2345702075 1.702413e-01 2.884870e-01 7 5389450 5390484 1035 - 0.458 0.163 -2.034
ENSG00000182095 E049 61.1990367 0.0185231064 1.799950e-03 6.599479e-03 7 5390485 5390628 144 - 1.900 1.665 -0.793
ENSG00000182095 E050 60.4221960 0.0104978597 9.166092e-07 7.670680e-06 7 5394440 5394595 156 - 1.944 1.623 -1.084
ENSG00000182095 E051 0.9630129 0.0691082017 9.749723e-01 9.884175e-01 7 5407150 5407394 245 - 0.286 0.279 -0.050
ENSG00000182095 E052 38.4006464 0.0126388825 1.521350e-09 2.180641e-08 7 5421060 5421489 430 - 1.819 1.356 -1.579
ENSG00000182095 E053 5.7190330 0.0579370303 8.109916e-02 1.612645e-01 7 5421830 5422032 203 - 0.972 0.688 -1.114
ENSG00000182095 E054 24.4541201 0.0007997370 1.897469e-08 2.222242e-07 7 5423441 5423834 394 - 1.599 1.204 -1.370
ENSG00000182095 E055 2.0188750 0.0076723462 8.431205e-03 2.486482e-02 7 5425291 5425414 124 - 0.716 0.280 -2.210