ENSG00000182087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356663 ENSG00000182087 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM259 protein_coding protein_coding 152.0845 189.7555 112.2276 17.76777 5.979459 -0.7576615 88.89641 117.41681 61.82732 10.552463 1.3566743 -0.9252120 0.5768458 0.6192667 0.5530667 -0.0662 0.1456673031 0.0002470004 FALSE  
ENST00000586285 ENSG00000182087 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM259 protein_coding protein_coding 152.0845 189.7555 112.2276 17.76777 5.979459 -0.7576615 17.77609 24.03034 14.59610 2.360847 0.5762609 -0.7188864 0.1196208 0.1266667 0.1302667 0.0036 0.8796921214 0.0002470004 FALSE  
ENST00000589055 ENSG00000182087 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM259 protein_coding retained_intron 152.0845 189.7555 112.2276 17.76777 5.979459 -0.7576615 14.86142 10.81841 13.72742 2.498401 0.9606848 0.3432904 0.1038333 0.0559000 0.1223000 0.0664 0.0002470004 0.0002470004 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182087 E001 3.620405 4.594771e-03 7.478751e-06 5.112974e-05 19 1009185 1009377 193 - 0.977 0.327 -2.917
ENSG00000182087 E002 5.672475 8.393705e-02 3.674689e-03 1.222446e-02 19 1009378 1009647 270 - 1.074 0.573 -1.986
ENSG00000182087 E003 3.134335 2.198585e-01 6.477039e-02 1.346681e-01 19 1009648 1009649 2 - 0.854 0.408 -1.979
ENSG00000182087 E004 3.281584 2.438857e-01 6.264538e-02 1.310959e-01 19 1009650 1009650 1 - 0.881 0.408 -2.087
ENSG00000182087 E005 7.308984 5.858827e-02 1.057744e-01 1.992744e-01 19 1009651 1009651 1 - 1.056 0.788 -1.015
ENSG00000182087 E006 11.479062 7.246601e-02 6.362367e-01 7.502934e-01 19 1009652 1009652 1 - 1.107 1.035 -0.263
ENSG00000182087 E007 42.808117 2.971564e-02 4.288853e-01 5.716147e-01 19 1009653 1009699 47 - 1.532 1.626 0.322
ENSG00000182087 E008 227.738733 8.528182e-03 3.558706e-02 8.278521e-02 19 1009700 1009719 20 - 2.226 2.345 0.397
ENSG00000182087 E009 981.736304 3.487269e-04 1.640654e-24 1.712491e-22 19 1009720 1009861 142 - 2.819 2.984 0.551
ENSG00000182087 E010 2106.110159 4.559975e-04 9.816889e-22 7.578566e-20 19 1009862 1010176 315 - 3.179 3.309 0.433
ENSG00000182087 E011 2477.780299 6.229850e-04 1.597219e-11 3.215603e-10 19 1010177 1010694 518 - 3.273 3.372 0.330
ENSG00000182087 E012 1252.755544 1.498824e-03 6.315752e-02 1.319708e-01 19 1010695 1010895 201 - 3.013 3.064 0.169
ENSG00000182087 E013 10.655394 3.015258e-02 2.562414e-01 3.932148e-01 19 1010896 1010990 95 - 1.123 0.972 -0.552
ENSG00000182087 E014 28.143166 2.062274e-03 7.464549e-01 8.342115e-01 19 1010991 1011095 105 - 1.391 1.419 0.097
ENSG00000182087 E015 1032.169375 3.480191e-04 6.164352e-03 1.904482e-02 19 1011096 1011195 100 - 2.929 2.977 0.158
ENSG00000182087 E016 92.029508 1.103436e-02 4.735994e-06 3.390341e-05 19 1011196 1011366 171 - 2.101 1.818 -0.949
ENSG00000182087 E017 1135.578881 5.554735e-04 5.812578e-01 7.058229e-01 19 1011367 1011499 133 - 3.007 3.006 -0.001
ENSG00000182087 E018 31.094107 6.766910e-04 6.672385e-01 7.745485e-01 19 1011500 1011579 80 - 1.430 1.464 0.115
ENSG00000182087 E019 630.608668 9.557539e-04 3.401660e-01 4.841257e-01 19 1011580 1011612 33 - 2.761 2.749 -0.042
ENSG00000182087 E020 510.132460 9.622707e-04 8.988241e-01 9.394681e-01 19 1011613 1011663 51 - 2.657 2.661 0.013
ENSG00000182087 E021 53.084436 4.365986e-04 3.863024e-01 5.304982e-01 19 1011664 1011740 77 - 1.711 1.671 -0.139
ENSG00000182087 E022 680.326591 1.743848e-04 3.919181e-01 5.358601e-01 19 1011741 1011798 58 - 2.770 2.788 0.062
ENSG00000182087 E023 5.896760 5.128948e-02 4.935913e-01 6.305846e-01 19 1011852 1011865 14 - 0.881 0.783 -0.382
ENSG00000182087 E024 9.284904 8.502589e-03 3.238240e-01 4.671602e-01 19 1011866 1011891 26 - 1.056 0.946 -0.405
ENSG00000182087 E025 949.331997 4.378718e-04 9.937628e-01 1.000000e+00 19 1011892 1011992 101 - 2.924 2.931 0.021
ENSG00000182087 E026 851.656657 1.096457e-04 7.482658e-01 8.355489e-01 19 1012066 1012112 47 - 2.880 2.880 0.001
ENSG00000182087 E027 922.611192 8.298063e-05 7.582158e-01 8.428590e-01 19 1012113 1012188 76 - 2.913 2.914 0.002
ENSG00000182087 E028 201.295393 4.881640e-03 4.180347e-10 6.641683e-09 19 1012189 1012462 274 - 2.420 2.168 -0.843
ENSG00000182087 E029 927.089107 1.076675e-04 2.861791e-02 6.924461e-02 19 1012463 1012540 78 - 2.933 2.909 -0.080
ENSG00000182087 E030 711.607927 1.146912e-03 6.265448e-04 2.630405e-03 19 1012541 1012573 33 - 2.849 2.784 -0.214
ENSG00000182087 E031 1006.738975 1.590895e-03 3.918203e-03 1.291347e-02 19 1013241 1013340 100 - 2.992 2.939 -0.175
ENSG00000182087 E032 33.242274 6.413542e-04 6.028631e-01 7.237497e-01 19 1013341 1013358 18 - 1.507 1.477 -0.103
ENSG00000182087 E033 13.194322 1.567424e-03 4.536116e-06 3.261132e-05 19 1013359 1013639 281 - 1.356 0.937 -1.506
ENSG00000182087 E034 982.420797 2.077887e-04 1.804099e-07 1.744226e-06 19 1014192 1014317 126 - 2.988 2.923 -0.217
ENSG00000182087 E035 955.726586 2.038795e-04 1.911067e-25 2.186267e-23 19 1014318 1014473 156 - 3.024 2.889 -0.448
ENSG00000182087 E036 3.335226 1.759943e-01 2.866749e-01 4.270976e-01 19 1017279 1017420 142 - 0.720 0.523 -0.866
ENSG00000182087 E037 686.653653 6.875629e-04 4.832239e-50 2.953075e-47 19 1020772 1021179 408 - 2.962 2.695 -0.888