ENSG00000182022

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435907 ENSG00000182022 HEK293_OSMI2_2hA HEK293_TMG_2hB CHST15 protein_coding protein_coding 5.871428 5.923588 6.637032 0.4508736 0.2075531 0.1638055 4.5481369 4.56952339 5.0615876 0.18590364 0.147561693 0.1472400 0.77735417 0.777600000 0.76406667 -0.01353333 9.392346e-01 6.744828e-06 FALSE  
ENST00000628426 ENSG00000182022 HEK293_OSMI2_2hA HEK293_TMG_2hB CHST15 protein_coding protein_coding 5.871428 5.923588 6.637032 0.4508736 0.2075531 0.1638055 0.3937983 0.68182098 0.1703869 0.06911955 0.003455557 -1.9393044 0.06744583 0.117700000 0.02573333 -0.09196667 1.648117e-04 6.744828e-06 FALSE  
MSTRG.4772.4 ENSG00000182022 HEK293_OSMI2_2hA HEK293_TMG_2hB CHST15 protein_coding   5.871428 5.923588 6.637032 0.4508736 0.2075531 0.1638055 0.2961987 0.03761902 0.5796115 0.03083801 0.082196637 3.6301549 0.04976250 0.005766667 0.08696667 0.08120000 6.744828e-06 6.744828e-06 TRUE  
MSTRG.4772.5 ENSG00000182022 HEK293_OSMI2_2hA HEK293_TMG_2hB CHST15 protein_coding   5.871428 5.923588 6.637032 0.4508736 0.2075531 0.1638055 0.4309959 0.40701621 0.5127096 0.18694102 0.018767766 0.3259061 0.06908750 0.064900000 0.07746667 0.01256667 8.094174e-01 6.744828e-06    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000182022 E001 165.028313 0.0009539725 7.205292e-12 1.535629e-10 10 124007668 124008666 999 - 2.097 2.295 0.663
ENSG00000182022 E002 74.620598 0.0063091528 8.184331e-03 2.425228e-02 10 124008667 124008827 161 - 1.789 1.932 0.482
ENSG00000182022 E003 67.028689 0.0024722981 6.441044e-03 1.976860e-02 10 124008828 124008926 99 - 1.752 1.882 0.439
ENSG00000182022 E004 97.869779 0.0003630473 8.633149e-02 1.695300e-01 10 124008927 124009210 284 - 1.955 2.015 0.200
ENSG00000182022 E005 183.813361 0.0006750166 4.633968e-02 1.026476e-01 10 124009211 124010339 1129 - 2.289 2.237 -0.172
ENSG00000182022 E006 2.731266 0.0331649464 2.798507e-02 6.798431e-02 10 124011735 124011806 72 - 0.299 0.688 1.964
ENSG00000182022 E007 48.375515 0.0090413810 2.666138e-02 6.528450e-02 10 124012333 124012480 148 - 1.760 1.614 -0.495
ENSG00000182022 E008 26.306454 0.0135294941 4.089559e-14 1.228404e-12 10 124019653 124021081 1429 - 0.882 1.636 2.677
ENSG00000182022 E009 9.606371 0.0020232508 1.863443e-09 2.625492e-08 10 124021082 124021255 174 - 0.475 1.223 2.984
ENSG00000182022 E010 49.501408 0.0007636313 8.199807e-03 2.429054e-02 10 124021256 124021412 157 - 1.765 1.633 -0.446
ENSG00000182022 E011 54.421194 0.0005523565 5.408994e-01 6.719549e-01 10 124038515 124038671 157 - 1.757 1.729 -0.098
ENSG00000182022 E012 44.399940 0.0005591678 5.343023e-01 6.663724e-01 10 124042301 124042447 147 - 1.675 1.643 -0.109
ENSG00000182022 E013 64.761903 0.0093317898 1.052559e-01 1.984832e-01 10 124044580 124044919 340 - 1.867 1.770 -0.327
ENSG00000182022 E014 62.937705 0.0081652867 1.065428e-04 5.521147e-04 10 124045667 124046012 346 - 1.914 1.684 -0.777
ENSG00000182022 E015 96.593672 0.0009313153 4.501545e-13 1.168545e-11 10 124046013 124046724 712 - 2.112 1.845 -0.896
ENSG00000182022 E016 1.800649 0.0084201046 7.282408e-01 8.207493e-01 10 124092324 124092454 131 - 0.475 0.415 -0.308
ENSG00000182022 E017 4.496651 0.0078984971 1.222543e-03 4.716857e-03 10 124092710 124093052 343 - 0.935 0.466 -1.983
ENSG00000182022 E018 12.608652 0.0301613081 6.335683e-02 1.322866e-01 10 124093469 124093598 130 - 1.243 1.014 -0.824