ENSG00000181991

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325844 ENSG00000181991 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS11 protein_coding protein_coding 44.45827 77.84417 27.20057 4.229522 0.8805216 -1.516607 17.240887 33.877588 9.184342 0.7139675 0.5914604 -1.88193874 0.3734458 0.4368333 0.3371333 -0.099700000 1.264749e-02 1.310675e-07 FALSE  
ENST00000559125 ENSG00000181991 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS11 protein_coding retained_intron 44.45827 77.84417 27.20057 4.229522 0.8805216 -1.516607 2.094218 1.976750 2.010888 0.1190814 0.1130484 0.02457929 0.0587625 0.0256000 0.0741000 0.048500000 1.310675e-07 1.310675e-07    
ENST00000559557 ENSG00000181991 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS11 protein_coding retained_intron 44.45827 77.84417 27.20057 4.229522 0.8805216 -1.516607 1.923411 1.592744 2.278312 0.2147558 0.1739503 0.51373932 0.0569500 0.0208000 0.0843000 0.063500000 4.239844e-07 1.310675e-07    
ENST00000560850 ENSG00000181991 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS11 protein_coding retained_intron 44.45827 77.84417 27.20057 4.229522 0.8805216 -1.516607 11.385786 18.707561 6.349104 3.1699166 0.8347674 -1.55749713 0.2533833 0.2375333 0.2320000 -0.005533333 9.891943e-01 1.310675e-07    
MSTRG.11477.2 ENSG00000181991 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS11 protein_coding   44.45827 77.84417 27.20057 4.229522 0.8805216 -1.516607 7.692396 14.868186 4.289385 0.5557011 0.1275080 -1.79099631 0.1613500 0.1914000 0.1583333 -0.033066667 2.380948e-01 1.310675e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181991 E001 4.800303 5.123000e-03 9.216838e-03 2.682679e-02 15 88467453 88467499 47 + 0.949 0.572 -1.531
ENSG00000181991 E002 8.010994 5.799270e-02 3.456650e-02 8.083808e-02 15 88467500 88467539 40 + 1.109 0.757 -1.333
ENSG00000181991 E003 9.303044 3.894007e-02 2.338994e-01 3.670148e-01 15 88467540 88467612 73 + 1.037 0.857 -0.676
ENSG00000181991 E004 13.105903 1.093515e-02 8.245110e-02 1.633732e-01 15 88467613 88467677 65 + 1.190 0.987 -0.735
ENSG00000181991 E005 79.949377 1.532523e-03 1.440449e-01 2.535211e-01 15 88467678 88467704 27 + 1.846 1.765 -0.272
ENSG00000181991 E006 87.662252 4.183445e-04 6.534687e-01 7.639333e-01 15 88467705 88467705 1 + 1.842 1.815 -0.089
ENSG00000181991 E007 88.763051 3.648689e-04 4.655689e-01 6.052373e-01 15 88467706 88467707 2 + 1.858 1.819 -0.133
ENSG00000181991 E008 162.421473 2.263795e-04 5.915928e-01 7.143302e-01 15 88467708 88467717 10 + 2.075 2.090 0.050
ENSG00000181991 E009 469.478692 8.268725e-04 9.321251e-01 9.612462e-01 15 88467718 88467735 18 + 2.552 2.544 -0.026
ENSG00000181991 E010 635.389923 3.098608e-03 8.631330e-01 9.157489e-01 15 88467736 88467782 47 + 2.678 2.677 -0.002
ENSG00000181991 E011 23.844114 1.010001e-02 1.313267e-02 3.621568e-02 15 88467783 88467907 125 + 1.457 1.225 -0.808
ENSG00000181991 E012 447.709544 4.501943e-03 8.380791e-01 8.987585e-01 15 88467908 88467910 3 + 2.523 2.525 0.006
ENSG00000181991 E013 793.881991 2.333757e-03 8.272208e-01 8.913754e-01 15 88467911 88467962 52 + 2.784 2.772 -0.040
ENSG00000181991 E014 992.711139 1.555598e-04 8.766353e-01 9.248117e-01 15 88467963 88468024 62 + 2.877 2.870 -0.024
ENSG00000181991 E015 75.951026 1.210654e-03 5.212846e-19 2.969206e-17 15 88468025 88469145 1121 + 2.075 1.663 -1.389
ENSG00000181991 E016 16.783863 1.891340e-03 1.266241e-12 3.055089e-11 15 88472236 88472354 119 + 1.555 0.941 -2.174
ENSG00000181991 E017 41.429332 8.084896e-03 5.455385e-06 3.850477e-05 15 88472355 88472506 152 + 1.766 1.436 -1.124
ENSG00000181991 E018 23.966898 4.247269e-03 6.773032e-02 1.395860e-01 15 88472507 88472626 120 + 1.415 1.255 -0.559
ENSG00000181991 E019 604.273510 1.570355e-04 1.902334e-01 3.140722e-01 15 88472627 88472646 20 + 2.640 2.661 0.068
ENSG00000181991 E020 1105.600411 1.529435e-04 3.641958e-01 5.085599e-01 15 88472647 88472725 79 + 2.912 2.920 0.028
ENSG00000181991 E021 24.148335 2.219964e-03 3.233905e-01 4.667196e-01 15 88475030 88475109 80 + 1.357 1.268 -0.311
ENSG00000181991 E022 1140.319270 8.214041e-05 6.031559e-02 1.271460e-01 15 88475110 88475171 62 + 2.915 2.936 0.069
ENSG00000181991 E023 1186.785350 1.312423e-04 1.804433e-03 6.613357e-03 15 88475172 88475239 68 + 2.918 2.956 0.127
ENSG00000181991 E024 16.164839 2.308186e-02 1.059099e-04 5.491804e-04 15 88476725 88476988 264 + 1.447 1.011 -1.547
ENSG00000181991 E025 1140.340105 1.655554e-04 4.806239e-04 2.085878e-03 15 88476989 88477054 66 + 2.895 2.940 0.151
ENSG00000181991 E026 1830.872456 3.412964e-03 3.982277e-01 5.419681e-01 15 88477872 88480776 2905 + 3.158 3.133 -0.085