ENSG00000181924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355693 ENSG00000181924 HEK293_OSMI2_2hA HEK293_TMG_2hB COA4 protein_coding protein_coding 167.4385 267.4532 123.7631 17.72646 0.770329 -1.111643 137.40905 226.90478 98.01467 15.669056 1.4159384 -1.210934 0.81387917 0.84803333 0.7918667 -0.056166667 4.421683e-05 2.166267e-07 FALSE  
ENST00000537289 ENSG00000181924 HEK293_OSMI2_2hA HEK293_TMG_2hB COA4 protein_coding protein_coding 167.4385 267.4532 123.7631 17.72646 0.770329 -1.111643 13.11317 21.28248 10.20300 2.011069 0.3407487 -1.059938 0.07858333 0.07926667 0.0824000 0.003133333 8.656721e-01 2.166267e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181924 E001 9.502031 0.0028934541 9.115692e-01 9.478789e-01 11 73872667 73872668 2 - 0.962 0.987 0.095
ENSG00000181924 E002 142.244786 0.0032613545 5.860874e-05 3.245331e-04 11 73872669 73872761 93 - 1.948 2.144 0.657
ENSG00000181924 E003 1473.639805 0.0014789442 6.407741e-05 3.514351e-04 11 73872762 73872996 235 - 3.049 3.128 0.263
ENSG00000181924 E004 3042.372667 0.0001229754 2.474857e-01 3.829883e-01 11 73872997 73873394 398 - 3.412 3.430 0.059
ENSG00000181924 E005 37.086330 0.0005855565 2.254580e-07 2.140055e-06 11 73873395 73873744 350 - 1.724 1.434 -0.990
ENSG00000181924 E006 9.790606 0.0218072604 3.606836e-02 8.371673e-02 11 73874421 73874475 55 - 1.154 0.905 -0.912
ENSG00000181924 E007 78.662683 0.0132168904 7.568838e-02 1.526052e-01 11 73875759 73876119 361 - 1.925 1.805 -0.404
ENSG00000181924 E008 31.688637 0.0006423161 7.086844e-16 2.731600e-14 11 73876155 73876478 324 - 1.760 1.276 -1.663
ENSG00000181924 E009 235.461004 0.0002056963 9.109931e-05 4.802162e-04 11 73876479 73876575 97 - 2.379 2.293 -0.288
ENSG00000181924 E010 56.037215 0.0004337096 5.762072e-09 7.440578e-08 11 73876576 73876756 181 - 1.883 1.614 -0.912
ENSG00000181924 E011 1218.853712 0.0008215968 4.102901e-03 1.343268e-02 11 73876757 73876901 145 - 3.053 3.018 -0.119