ENSG00000181894

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358067 ENSG00000181894 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF329 protein_coding protein_coding 1.210855 0.8031555 1.521408 0.05649711 0.08732007 0.9132556 0.27859748 0.58826866 0.0000000 0.01605966 0.00000000 -5.9027216 0.30615417 0.74153333 0.00000000 -0.741533333 1.721515e-13 1.721515e-13 FALSE TRUE
ENST00000500161 ENSG00000181894 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF329 protein_coding nonsense_mediated_decay 1.210855 0.8031555 1.521408 0.05649711 0.08732007 0.9132556 0.15401611 0.09436032 0.1081508 0.02284476 0.05670953 0.1790560 0.12492083 0.11680000 0.07206667 -0.044733333 7.243893e-01 1.721515e-13 TRUE TRUE
ENST00000597186 ENSG00000181894 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF329 protein_coding protein_coding 1.210855 0.8031555 1.521408 0.05649711 0.08732007 0.9132556 0.06593923 0.07364514 0.1545104 0.02111200 0.07726696 0.9758252 0.05976667 0.08883333 0.09780000 0.008966667 9.973451e-01 1.721515e-13 FALSE TRUE
ENST00000598312 ENSG00000181894 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF329 protein_coding protein_coding 1.210855 0.8031555 1.521408 0.05649711 0.08732007 0.9132556 0.35219635 0.04688138 0.4446376 0.04688138 0.13602395 2.9986888 0.26780417 0.05283333 0.29643333 0.243600000 1.680306e-01 1.721515e-13 FALSE TRUE
MSTRG.17826.3 ENSG00000181894 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF329 protein_coding   1.210855 0.8031555 1.521408 0.05649711 0.08732007 0.9132556 0.34197272 0.00000000 0.8141092 0.00000000 0.15059813 6.3647637 0.23302083 0.00000000 0.53370000 0.533700000 1.224892e-06 1.721515e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181894 E001 0.1817044 0.0401005420 0.29314943   19 58126248 58126251 4 - 0.000 0.154 9.103
ENSG00000181894 E002 0.7813216 0.0361049831 0.32806540 0.47151025 19 58126252 58126329 78 - 0.176 0.356 1.342
ENSG00000181894 E003 0.7813216 0.0361049831 0.32806540 0.47151025 19 58126330 58126334 5 - 0.176 0.356 1.342
ENSG00000181894 E004 11.7129099 0.0023038752 0.02599236 0.06393289 19 58126335 58126763 429 - 1.000 1.211 0.763
ENSG00000181894 E005 19.3162776 0.0179817964 0.08006018 0.15964929 19 58126764 58127424 661 - 1.230 1.386 0.546
ENSG00000181894 E006 61.7573212 0.0005893905 0.02038775 0.05230129 19 58127425 58129375 1951 - 1.822 1.759 -0.216
ENSG00000181894 E007 7.5053551 0.0114431755 0.08323322 0.16462852 19 58129376 58129511 136 - 0.999 0.785 -0.819
ENSG00000181894 E008 1.1342099 0.0223593496 0.77076277 0.85201155 19 58132242 58132676 435 - 0.301 0.357 0.350
ENSG00000181894 E009 4.5006005 0.0036421201 0.73341177 0.82461978 19 58142557 58142661 105 - 0.759 0.719 -0.163
ENSG00000181894 E010 0.0000000       19 58142662 58142664 3 -      
ENSG00000181894 E011 1.8121785 0.0080603954 0.35891357 0.50327597 19 58143105 58143198 94 - 0.512 0.356 -0.823
ENSG00000181894 E012 1.1458512 0.0119635804 0.62587726 0.74192391 19 58150752 58150796 45 - 0.352 0.267 -0.557
ENSG00000181894 E013 1.1500158 0.0121105437 0.29717404 0.43848071 19 58154735 58155110 376 - 0.243 0.431 1.178