ENSG00000181852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345093 ENSG00000181852 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF41 protein_coding protein_coding 46.00065 63.59329 38.24317 3.185078 0.4194148 -0.733522 6.145186 8.303434 5.587152 0.8232052 0.2011398 -0.5707517 0.13471250 0.13030000 0.14610000 0.01580000 0.6691090318 0.0001311298 FALSE TRUE
ENST00000394013 ENSG00000181852 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF41 protein_coding protein_coding 46.00065 63.59329 38.24317 3.185078 0.4194148 -0.733522 18.481096 26.913028 13.180061 2.0521702 0.3952558 -1.0293894 0.39548333 0.42213333 0.34496667 -0.07716667 0.0389421752 0.0001311298 FALSE TRUE
ENST00000548225 ENSG00000181852 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF41 protein_coding retained_intron 46.00065 63.59329 38.24317 3.185078 0.4194148 -0.733522 2.940462 5.203593 1.948381 0.1027037 0.4451283 -1.4126165 0.06104167 0.08233333 0.05083333 -0.03150000 0.2065809787 0.0001311298 FALSE TRUE
ENST00000552656 ENSG00000181852 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF41 protein_coding protein_coding 46.00065 63.59329 38.24317 3.185078 0.4194148 -0.733522 15.110672 17.445789 15.245695 1.3668700 0.6875346 -0.1943577 0.33786667 0.27386667 0.39836667 0.12450000 0.0001311298 0.0001311298 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181852 E001 24.2600709 0.0011263043 2.166158e-01 3.463251e-01 12 56202179 56202503 325 - 1.429 1.344 -0.298
ENSG00000181852 E002 695.9730979 0.0042028783 4.191336e-01 5.623803e-01 12 56202504 56205449 2946 - 2.781 2.811 0.100
ENSG00000181852 E003 1082.4588015 0.0002122573 9.390179e-22 7.263950e-20 12 56205450 56206408 959 - 2.906 3.028 0.406
ENSG00000181852 E004 214.3831466 0.0003001659 1.686379e-01 2.863976e-01 12 56206409 56206446 38 - 2.266 2.307 0.136
ENSG00000181852 E005 370.7585215 0.0001644110 4.511428e-01 5.921273e-01 12 56206447 56206586 140 - 2.538 2.527 -0.038
ENSG00000181852 E006 404.1516776 0.0007532154 4.353789e-01 5.776199e-01 12 56206587 56206748 162 - 2.576 2.561 -0.050
ENSG00000181852 E007 212.9036040 0.0027039445 4.528332e-01 5.936427e-01 12 56206749 56206798 50 - 2.268 2.297 0.095
ENSG00000181852 E008 4.4618856 0.0048501401 6.588496e-01 7.678499e-01 12 56207168 56207310 143 - 0.750 0.690 -0.248
ENSG00000181852 E009 2.2478089 0.0106088549 4.127062e-03 1.349779e-02 12 56207639 56207645 7 - 0.750 0.283 -2.333
ENSG00000181852 E010 181.7960428 0.0002254977 8.015699e-02 1.597852e-01 12 56207646 56207676 31 - 2.253 2.207 -0.152
ENSG00000181852 E011 242.6778241 0.0004737318 1.792059e-01 3.001414e-01 12 56207677 56207749 73 - 2.367 2.335 -0.105
ENSG00000181852 E012 0.1482932 0.0414373625 1.000000e+00   12 56208148 56208162 15 - 0.000 0.089 8.398
ENSG00000181852 E013 343.0243127 0.0005285748 1.329227e-02 3.659986e-02 12 56208163 56208298 136 - 2.531 2.479 -0.174
ENSG00000181852 E014 4.1469274 0.2723598139 1.066983e-01 2.006758e-01 12 56208299 56208544 246 - 0.874 0.539 -1.400
ENSG00000181852 E015 37.6508803 0.0082493412 6.749645e-05 3.680454e-04 12 56210037 56210247 211 - 1.290 1.617 1.129
ENSG00000181852 E016 39.8073838 0.0400218518 1.798039e-03 6.593114e-03 12 56210248 56210296 49 - 1.279 1.650 1.277
ENSG00000181852 E017 536.4073353 0.0004123424 5.020935e-02 1.095257e-01 12 56210297 56210568 272 - 2.712 2.680 -0.106
ENSG00000181852 E018 0.0000000       12 56212992 56212995 4 -      
ENSG00000181852 E019 34.4347679 0.0016448505 3.607793e-04 1.621902e-03 12 56212996 56213061 66 - 1.657 1.440 -0.741
ENSG00000181852 E020 21.3822222 0.0062961654 1.101137e-01 2.057005e-01 12 56213062 56213077 16 - 1.406 1.279 -0.444
ENSG00000181852 E021 28.2809882 0.0007171347 3.658314e-01 5.101381e-01 12 56213078 56213138 61 - 1.472 1.414 -0.199
ENSG00000181852 E022 361.0338902 0.0001892550 2.600042e-04 1.216806e-03 12 56213958 56214070 113 - 2.567 2.499 -0.229
ENSG00000181852 E023 454.9776350 0.0010577551 7.726283e-05 4.151105e-04 12 56216429 56216613 185 - 2.676 2.591 -0.285
ENSG00000181852 E024 1.5310298 0.2823023098 5.996643e-01 7.210263e-01 12 56221591 56221759 169 - 0.453 0.337 -0.651
ENSG00000181852 E025 207.4713774 0.0056884272 1.819367e-01 3.036397e-01 12 56221760 56221902 143 - 2.316 2.260 -0.187
ENSG00000181852 E026 57.4970783 0.0031288850 3.283736e-02 7.748473e-02 12 56221903 56221933 31 - 1.802 1.688 -0.386