ENSG00000181830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314134 ENSG00000181830 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C1 protein_coding protein_coding 12.47673 19.23117 8.257404 0.8817807 0.2713929 -1.21869 9.2726766 12.260565 7.5315104 1.3367113 0.13888902 -0.7022763 0.7730750 0.63383333 0.91340000 0.2795667 1.737649e-04 1.004153e-09 FALSE TRUE
ENST00000442528 ENSG00000181830 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C1 protein_coding protein_coding 12.47673 19.23117 8.257404 0.8817807 0.2713929 -1.21869 0.7032034 1.696226 0.4989627 0.1817351 0.08235631 -1.7451769 0.0527875 0.08846667 0.06036667 -0.0281000 4.141191e-01 1.004153e-09 FALSE TRUE
MSTRG.5435.1 ENSG00000181830 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35C1 protein_coding   12.47673 19.23117 8.257404 0.8817807 0.2713929 -1.21869 2.2280454 4.479308 0.0000000 1.1110980 0.00000000 -8.8103493 0.1555375 0.23763333 0.00000000 -0.2376333 1.004153e-09 1.004153e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181830 E001 0.5503986 0.0210941882 0.8481146164 0.905715156 11 45804042 45804071 30 + 0.181 0.150 -0.331
ENSG00000181830 E002 0.5503986 0.0210941882 0.8481146164 0.905715156 11 45804072 45804085 14 + 0.181 0.149 -0.330
ENSG00000181830 E003 1.3714610 0.0104249148 0.5846424726 0.708515992 11 45804086 45804153 68 + 0.406 0.307 -0.595
ENSG00000181830 E004 8.0392195 0.0021572372 0.6039422951 0.724613713 11 45804154 45804420 267 + 0.942 0.879 -0.239
ENSG00000181830 E005 9.0958205 0.0019004666 0.9193883105 0.953069500 11 45804421 45804517 97 + 0.942 0.954 0.046
ENSG00000181830 E006 13.3344270 0.0234881579 0.1947682658 0.319712074 11 45805149 45805316 168 + 1.204 1.053 -0.543
ENSG00000181830 E007 149.9990545 0.0034506562 0.0009266745 0.003708480 11 45805317 45805809 493 + 2.203 2.076 -0.426
ENSG00000181830 E008 245.8539193 0.0002749275 0.4787979380 0.617225437 11 45805810 45806336 527 + 2.339 2.323 -0.055
ENSG00000181830 E009 968.7716358 0.0005629253 0.0002761544 0.001282616 11 45810776 45813016 2241 + 2.897 2.929 0.104