ENSG00000181704

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000451537 ENSG00000181704 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF6 protein_coding protein_coding 17.57594 10.18049 25.94929 1.56677 0.4989629 1.349027 1.1025912 0.7795752 2.4002553 0.09150475 0.20070712 1.6100374 0.06310417 0.08270000 0.092633333 0.009933333 0.81148547 0.02405788 FALSE  
ENST00000462683 ENSG00000181704 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF6 protein_coding protein_coding 17.57594 10.18049 25.94929 1.56677 0.4989629 1.349027 9.0009668 3.4098693 12.9773898 1.13109938 0.46991352 1.9250984 0.48580000 0.31940000 0.500033333 0.180633333 0.07527255 0.02405788 FALSE  
ENST00000462972 ENSG00000181704 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF6 protein_coding processed_transcript 17.57594 10.18049 25.94929 1.56677 0.4989629 1.349027 0.2579396 0.6544154 0.1512759 0.25630754 0.07570433 -2.0425546 0.02268333 0.05956667 0.005933333 -0.053633333 0.02405788 0.02405788    
MSTRG.34380.2 ENSG00000181704 HEK293_OSMI2_2hA HEK293_TMG_2hB YIPF6 protein_coding   17.57594 10.18049 25.94929 1.56677 0.4989629 1.349027 6.5459108 4.9848397 9.4443538 0.47612147 0.42067034 0.9205405 0.38940417 0.49986667 0.363700000 -0.136166667 0.07688586 0.02405788 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181704 E001 21.8900118 0.0198932804 7.454543e-01 8.334853e-01 X 68498562 68498781 220 + 1.371 1.269 -0.354
ENSG00000181704 E002 32.0929149 0.0144723407 8.825354e-01 9.288022e-01 X 68498782 68499033 252 + 1.525 1.444 -0.278
ENSG00000181704 E003 18.9455029 0.0032829037 1.157889e-01 2.139311e-01 X 68499034 68499048 15 + 1.341 1.149 -0.675
ENSG00000181704 E004 21.3425473 0.0011437328 4.137959e-01 5.571994e-01 X 68499049 68499050 2 + 1.370 1.255 -0.402
ENSG00000181704 E005 72.9575252 0.0013343810 5.312665e-01 6.637442e-01 X 68499051 68499080 30 + 1.860 1.835 -0.084
ENSG00000181704 E006 96.7723249 0.0003486059 6.816284e-02 1.403187e-01 X 68499081 68499123 43 + 1.969 1.987 0.060
ENSG00000181704 E007 5.2756785 0.0032209382 9.252091e-02 1.790562e-01 X 68499124 68499157 34 + 0.711 0.892 0.715
ENSG00000181704 E008 5.3120042 0.0031362294 3.522789e-06 2.597119e-05 X 68510679 68510776 98 + 0.502 1.067 2.293
ENSG00000181704 E009 0.4741261 0.0215994828 8.530332e-01 9.089636e-01 X 68511807 68511848 42 + 0.157 0.172 0.157
ENSG00000181704 E010 146.1372005 0.0004465020 8.732916e-02 1.710884e-01 X 68511849 68511977 129 + 2.154 2.157 0.008
ENSG00000181704 E011 131.4091931 0.0025259410 7.733046e-03 2.310862e-02 X 68513327 68513405 79 + 2.090 2.138 0.162
ENSG00000181704 E012 7.0534664 0.0193637389 4.277082e-01 5.705476e-01 X 68513406 68515340 1935 + 0.936 0.769 -0.647
ENSG00000181704 E013 113.3769485 0.0003053671 1.958210e-07 1.879792e-06 X 68518770 68518812 43 + 1.998 2.124 0.422
ENSG00000181704 E014 154.9052840 0.0002565450 1.451137e-07 1.428939e-06 X 68521372 68521497 126 + 2.140 2.241 0.340
ENSG00000181704 E015 196.2184696 0.0030793208 7.772472e-04 3.177402e-03 X 68522760 68522917 158 + 2.256 2.323 0.221
ENSG00000181704 E016 1333.7364281 0.0030727445 9.865216e-09 1.218024e-07 X 68531881 68537282 5402 + 3.153 3.009 -0.477
ENSG00000181704 E017 0.7374030 0.0155981923 6.837577e-01 7.868817e-01 X 68570984 68571013 30 + 0.272 0.172 -0.845