ENSG00000181666

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392153 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding protein_coding 9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.7201173 0.7628037 1.2352976 0.4253095 0.23680071 0.6883167 0.09007500 0.07653333 0.19933333 0.1228000000 2.595987e-01 3.164471e-10 FALSE  
ENST00000544914 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding protein_coding 9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.5767639 0.9728686 0.5295680 0.2953124 0.29976747 -0.8651938 0.06408333 0.09786667 0.08670000 -0.0111666667 8.588339e-01 3.164471e-10 FALSE  
ENST00000588820 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding retained_intron 9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.9254923 1.1480404 0.0000000 0.8044270 0.00000000 -6.8555418 0.08081250 0.11786667 0.00000000 -0.1178666667 2.257307e-01 3.164471e-10 FALSE  
ENST00000589218 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding processed_transcript 9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.6917976 0.8276061 0.3246252 0.1014695 0.09684614 -1.3237260 0.07078333 0.08363333 0.05143333 -0.0322000000 4.651552e-01 3.164471e-10    
ENST00000590166 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding protein_coding 9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.6562623 0.5810332 0.2071107 0.1402940 0.02721579 -1.4448081 0.05932500 0.05860000 0.03320000 -0.0254000000 4.451551e-01 3.164471e-10    
MSTRG.17066.11 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding   9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.2314478 0.0000000 0.5289481 0.0000000 0.09446849 5.7520745 0.03179583 0.00000000 0.08436667 0.0843666667 3.164471e-10 3.164471e-10 FALSE  
MSTRG.17066.12 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding   9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.6262231 0.8391823 0.5319657 0.1044148 0.11062165 -0.6478729 0.06373333 0.08473333 0.08570000 0.0009666667 1.000000e+00 3.164471e-10    
MSTRG.17066.21 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding   9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.8335433 0.7561348 0.1561327 0.5365152 0.08330230 -2.2052623 0.07975000 0.07576667 0.02553333 -0.0502333333 8.959963e-01 3.164471e-10 FALSE  
MSTRG.17066.6 ENSG00000181666 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF875 protein_coding   9.582084 9.880689 6.243342 0.1035239 0.1175466 -0.6614435 0.1231786 0.0000000 0.4842462 0.0000000 0.25298584 5.6271579 0.01606667 0.00000000 0.07613333 0.0761333333 1.305798e-01 3.164471e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181666 E001 0.0000000       19 37312837 37312877 41 +      
ENSG00000181666 E002 0.0000000       19 37312878 37313312 435 +      
ENSG00000181666 E003 0.0000000       19 37316995 37317142 148 +      
ENSG00000181666 E004 0.8179419 0.0159494554 0.331693878 0.47534236 19 37317887 37317899 13 + 0.341 0.186 -1.162
ENSG00000181666 E005 1.3693847 0.0100205670 0.965750226 0.98246985 19 37317900 37317903 4 + 0.341 0.368 0.160
ENSG00000181666 E006 1.3693847 0.0100205670 0.965750226 0.98246985 19 37317904 37317904 1 + 0.341 0.368 0.160
ENSG00000181666 E007 2.0421539 0.0929410158 0.867591546 0.91884289 19 37317905 37317910 6 + 0.476 0.458 -0.089
ENSG00000181666 E008 2.4818247 0.0063357819 0.243122116 0.37784979 19 37317911 37317914 4 + 0.621 0.457 -0.769
ENSG00000181666 E009 2.7032699 0.0075516226 0.349576347 0.49378679 19 37317915 37317916 2 + 0.621 0.496 -0.576
ENSG00000181666 E010 2.8547853 0.0165319148 0.242136571 0.37671986 19 37317917 37317918 2 + 0.661 0.496 -0.745
ENSG00000181666 E011 5.4679513 0.0040376664 0.128879580 0.23259836 19 37317919 37317930 12 + 0.890 0.721 -0.664
ENSG00000181666 E012 13.9247070 0.0014582042 0.166786276 0.28400154 19 37317931 37318038 108 + 1.207 1.114 -0.332
ENSG00000181666 E013 13.2281933 0.0019290495 0.048780675 0.10699477 19 37318039 37318079 41 + 1.218 1.067 -0.539
ENSG00000181666 E014 20.2207565 0.0046191030 0.053167809 0.11478874 19 37318080 37318186 107 + 1.381 1.257 -0.433
ENSG00000181666 E015 12.7582610 0.0014635735 0.036515361 0.08456154 19 37322185 37322232 48 + 1.218 1.057 -0.577
ENSG00000181666 E016 12.2650921 0.0018546139 0.118040010 0.21712893 19 37323533 37323570 38 + 1.173 1.057 -0.420
ENSG00000181666 E017 14.7956520 0.0028880112 0.363340329 0.50775161 19 37324208 37324265 58 + 1.207 1.156 -0.179
ENSG00000181666 E018 8.2105208 0.0023833535 0.222877097 0.35379869 19 37324796 37324936 141 + 1.006 0.899 -0.399
ENSG00000181666 E019 6.1109800 0.0271281398 0.731612148 0.82324129 19 37324937 37325077 141 + 0.842 0.821 -0.083
ENSG00000181666 E020 2.9786511 0.0051722169 0.595925783 0.71794639 19 37325078 37325101 24 + 0.621 0.564 -0.255
ENSG00000181666 E021 3.4925180 0.0053421644 0.390683617 0.53464487 19 37325102 37325128 27 + 0.697 0.595 -0.439
ENSG00000181666 E022 2.6068364 0.0058761649 0.346274863 0.49042144 19 37325129 37325153 25 + 0.621 0.496 -0.577
ENSG00000181666 E023 5.5489517 0.0192210422 0.653081096 0.76365926 19 37325154 37325274 121 + 0.730 0.821 0.364
ENSG00000181666 E024 24.0333527 0.0009326847 0.009853283 0.02840475 19 37328579 37329024 446 + 1.218 1.446 0.796
ENSG00000181666 E025 6.8827592 0.0033531565 0.080318589 0.16006517 19 37329025 37329064 40 + 0.697 0.954 1.008
ENSG00000181666 E026 6.8922093 0.0238258531 0.060525964 0.12751697 19 37329065 37329105 41 + 0.660 0.966 1.207
ENSG00000181666 E027 9.5333237 0.0018281395 0.007530387 0.02259080 19 37329172 37329245 74 + 0.761 1.104 1.297
ENSG00000181666 E028 0.0000000       19 37334624 37334639 16 +      
ENSG00000181666 E029 0.0000000       19 37334640 37334648 9 +      
ENSG00000181666 E030 0.0000000       19 37334649 37334655 7 +      
ENSG00000181666 E031 0.0000000       19 37334656 37334656 1 +      
ENSG00000181666 E032 0.0000000       19 37334657 37334657 1 +      
ENSG00000181666 E033 1.2479471 0.5561402346 0.653567689 0.76399883 19 37334658 37334670 13 + 0.475 0.253 -1.330
ENSG00000181666 E034 1.2479471 0.5561402346 0.653567689 0.76399883 19 37334671 37334677 7 + 0.475 0.253 -1.330
ENSG00000181666 E035 5.6356627 0.0253314541 0.415153152 0.55855879 19 37334678 37334711 34 + 0.867 0.781 -0.336
ENSG00000181666 E036 5.8184112 0.0252770364 0.688868853 0.79090542 19 37334712 37334727 16 + 0.843 0.817 -0.100
ENSG00000181666 E037 7.8103169 0.0028893038 0.290287728 0.43107977 19 37334728 37334782 55 + 0.989 0.899 -0.337
ENSG00000181666 E038 1.9678466 0.0123613198 0.005489537 0.01726073 19 37334783 37335168 386 + 0.697 0.255 -2.316
ENSG00000181666 E039 5.3716588 0.0981496368 0.097312405 0.18637575 19 37335169 37335199 31 + 0.932 0.678 -1.005
ENSG00000181666 E040 7.1368088 0.1055474018 0.038474833 0.08823851 19 37335200 37335257 58 + 1.069 0.748 -1.222
ENSG00000181666 E041 2.6625100 0.0648507789 0.725393198 0.81867227 19 37344610 37344774 165 + 0.578 0.532 -0.215
ENSG00000181666 E042 1.5961285 0.1069254752 0.775011560 0.85502474 19 37344775 37344933 159 + 0.414 0.372 -0.235
ENSG00000181666 E043 1.4361053 0.0095059363 0.107409648 0.20172131 19 37344934 37345021 88 + 0.145 0.457 2.231
ENSG00000181666 E044 1.2104955 0.0391025211 0.817314188 0.88447523 19 37346297 37346355 59 + 0.341 0.316 -0.156
ENSG00000181666 E045 1.7317493 0.0088830100 0.913092449 0.94892771 19 37346356 37346422 67 + 0.413 0.415 0.009
ENSG00000181666 E046 2.9347681 0.0111864294 0.206368596 0.33416166 19 37346423 37346492 70 + 0.413 0.650 1.124
ENSG00000181666 E047 2.3615555 0.0065697187 0.846822123 0.90481834 19 37346493 37346675 183 + 0.475 0.531 0.271
ENSG00000181666 E048 2.9839471 0.0059338953 0.449624263 0.59081810 19 37346772 37346887 116 + 0.475 0.623 0.687
ENSG00000181666 E049 3.0862559 0.0096846314 0.068864458 0.14148933 19 37346888 37347052 165 + 0.341 0.676 1.649
ENSG00000181666 E050 2.6131765 0.0061017871 0.349150531 0.49336924 19 37347053 37347189 137 + 0.413 0.595 0.883
ENSG00000181666 E051 13.1560683 0.0067419966 0.598041465 0.71971524 19 37347190 37347206 17 + 1.137 1.115 -0.079
ENSG00000181666 E052 15.2865013 0.0012738204 0.496457964 0.63310314 19 37347207 37347231 25 + 1.207 1.180 -0.096
ENSG00000181666 E053 21.1625345 0.0009074232 0.791646980 0.86673670 19 37347232 37347316 85 + 1.320 1.333 0.046
ENSG00000181666 E054 0.3299976 0.0274424043 0.362996760   19 37347563 37347776 214 + 0.000 0.185 16.191
ENSG00000181666 E055 27.3953433 0.0008137327 0.836366078 0.89766363 19 37347777 37347872 96 + 1.422 1.442 0.067
ENSG00000181666 E056 1.9196841 0.0077015020 0.413237015 0.55675060 19 37357962 37358039 78 + 0.530 0.415 -0.578
ENSG00000181666 E057 0.6298062 0.0176707001 0.584712289 0.70856887 19 37358541 37358546 6 + 0.145 0.255 1.005
ENSG00000181666 E058 0.2998086 0.0288589367 0.724799792   19 37358547 37358661 115 + 0.145 0.102 -0.580
ENSG00000181666 E059 4.0494577 0.1130573869 0.645007937 0.75722911 19 37359426 37359546 121 + 0.578 0.714 0.586
ENSG00000181666 E060 3.5396563 0.0047405284 0.213383218 0.34251348 19 37359547 37359776 230 + 0.475 0.699 1.009
ENSG00000181666 E061 0.8416995 0.0367687006 0.060437952 0.12736190 19 37361968 37362105 138 + 0.000 0.367 17.344
ENSG00000181666 E062 2.9387449 0.2114956539 0.096518209 0.18514105 19 37362106 37362108 3 + 0.254 0.708 2.365
ENSG00000181666 E063 353.4335613 0.0160371734 0.250794426 0.38687608 19 37362109 37364455 2347 + 2.484 2.556 0.242
ENSG00000181666 E064 0.2214452 0.0385613135 0.740185682   19 37369179 37369365 187 + 0.000 0.103 15.226