ENSG00000181555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409792 ENSG00000181555 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD2 protein_coding protein_coding 20.30656 16.29468 23.04039 0.7980275 0.7369842 0.4995055 7.9955247 1.0959028 14.4607958 0.3649841 0.51297258 3.7098477 0.34915417 0.06816667 0.628600000 0.560433333 4.194126e-10 4.194126e-10 FALSE TRUE
ENST00000685005 ENSG00000181555 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD2 protein_coding protein_coding 20.30656 16.29468 23.04039 0.7980275 0.7369842 0.4995055 1.7398118 0.8595708 0.9944450 0.1467947 0.36939091 0.2080231 0.07834583 0.05313333 0.044200000 -0.008933333 8.047563e-01 4.194126e-10 FALSE TRUE
ENST00000687657 ENSG00000181555 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD2 protein_coding retained_intron 20.30656 16.29468 23.04039 0.7980275 0.7369842 0.4995055 1.9127822 5.3584603 0.1633156 2.1440637 0.01511848 -4.9530347 0.12110833 0.32316667 0.007133333 -0.316033333 4.515823e-05 4.194126e-10 FALSE TRUE
ENST00000690157 ENSG00000181555 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD2 protein_coding protein_coding 20.30656 16.29468 23.04039 0.7980275 0.7369842 0.4995055 0.7354818 0.7633390 0.0000000 0.6961621 0.00000000 -6.2730290 0.03990000 0.05020000 0.000000000 -0.050200000 2.324547e-01 4.194126e-10 FALSE TRUE
ENST00000691544 ENSG00000181555 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD2 protein_coding protein_coding 20.30656 16.29468 23.04039 0.7980275 0.7369842 0.4995055 2.9166354 4.4507879 0.5210760 0.9095303 0.52107602 -3.0703082 0.16501667 0.27490000 0.021833333 -0.253066667 3.163144e-02 4.194126e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181555 E001 0.1482932 0.0421831357 2.495223e-01   3 47016428 47016428 1 - 0.000 0.159 12.490
ENSG00000181555 E002 0.8846495 0.0217142604 3.615326e-02 8.388602e-02 3 47016429 47016435 7 - 0.093 0.443 2.888
ENSG00000181555 E003 2.5453074 0.0907259306 7.663689e-05 4.121215e-04 3 47016436 47016442 7 - 0.093 0.832 4.598
ENSG00000181555 E004 2.5453074 0.0907259306 7.663689e-05 4.121215e-04 3 47016443 47016444 2 - 0.093 0.832 4.598
ENSG00000181555 E005 87.8702872 0.0215810863 6.163720e-18 3.098165e-16 3 47016445 47016688 244 - 1.531 2.228 2.348
ENSG00000181555 E006 505.4242148 0.0174691955 1.604679e-09 2.289686e-08 3 47016689 47017254 566 - 2.523 2.871 1.159
ENSG00000181555 E007 243.4089469 0.0051897489 5.454474e-13 1.395454e-11 3 47017638 47017739 102 - 2.250 2.519 0.897
ENSG00000181555 E008 201.8658021 0.0065019051 5.383833e-05 3.009326e-04 3 47019760 47019840 81 - 2.226 2.386 0.534
ENSG00000181555 E009 0.1515154 0.0427780686 1.000000e+00   3 47028228 47028308 81 - 0.093 0.000 -11.023
ENSG00000181555 E010 0.2966881 0.0270714220 4.565639e-01   3 47037665 47037665 1 - 0.170 0.000 -12.023
ENSG00000181555 E011 180.1918503 0.0006073914 5.971532e-14 1.752035e-12 3 47037666 47037777 112 - 2.162 2.348 0.619
ENSG00000181555 E012 4.2500951 0.0037986182 3.614132e-01 5.057964e-01 3 47041360 47041483 124 - 0.662 0.769 0.440
ENSG00000181555 E013 168.6400979 0.0008811263 4.453840e-09 5.857051e-08 3 47042561 47042700 140 - 2.149 2.300 0.503
ENSG00000181555 E014 168.2641207 0.0028730646 1.955467e-07 1.877254e-06 3 47046487 47046621 135 - 2.140 2.308 0.560
ENSG00000181555 E015 0.0000000       3 47046622 47047027 406 -      
ENSG00000181555 E016 382.8430575 0.0003770366 1.931202e-07 1.856029e-06 3 47056821 47057490 670 - 2.540 2.615 0.248
ENSG00000181555 E017 0.0000000       3 47061401 47061494 94 -      
ENSG00000181555 E018 0.4513240 0.2232817069 1.000000e+00 1.000000e+00 3 47062160 47062162 3 - 0.170 0.158 -0.135
ENSG00000181555 E019 169.5985142 0.0007667496 6.572249e-01 7.666262e-01 3 47062163 47062346 184 - 2.225 2.211 -0.049
ENSG00000181555 E020 0.9016039 0.2314557302 4.757689e-01 6.144495e-01 3 47064555 47064630 76 - 0.343 0.157 -1.460
ENSG00000181555 E021 89.6912947 0.0004408997 4.343608e-02 9.735732e-02 3 47067070 47067118 49 - 1.984 1.875 -0.368
ENSG00000181555 E022 0.8135738 0.0941860607 4.963695e-02 1.085227e-01 3 47067119 47067397 279 - 0.093 0.440 2.875
ENSG00000181555 E023 0.9985004 0.0121989077 1.026064e-01 1.944741e-01 3 47073005 47073147 143 - 0.170 0.442 1.887
ENSG00000181555 E024 4.2866308 0.0036651804 5.739024e-01 6.998114e-01 3 47079512 47079611 100 - 0.762 0.657 -0.436
ENSG00000181555 E025 1.3736537 0.0111771897 4.607755e-01 6.007658e-01 3 47079612 47079739 128 - 0.427 0.275 -0.921
ENSG00000181555 E026 16.4377776 0.0010720141 3.693247e-01 5.137451e-01 3 47079740 47080800 1061 - 1.213 1.262 0.173
ENSG00000181555 E027 10.7133192 0.0021622456 9.676913e-01 9.838158e-01 3 47080801 47080898 98 - 1.071 1.048 -0.081
ENSG00000181555 E028 6.8288349 0.0235976798 7.548879e-01 8.403872e-01 3 47080899 47080915 17 - 0.886 0.905 0.070
ENSG00000181555 E029 22.4324458 0.0167075603 6.741797e-01 7.796870e-01 3 47080916 47081083 168 - 1.389 1.319 -0.244
ENSG00000181555 E030 368.9544080 0.0041852466 4.998356e-01 6.360955e-01 3 47083720 47084382 663 - 2.575 2.526 -0.160
ENSG00000181555 E031 107.6476667 0.0008710342 3.891234e-01 5.332321e-01 3 47086195 47086314 120 - 2.046 1.986 -0.204
ENSG00000181555 E032 1.7984489 0.0186773255 2.007757e-01 3.271650e-01 3 47086315 47086698 384 - 0.530 0.275 -1.435
ENSG00000181555 E033 90.3882718 0.0080708101 4.898411e-01 6.272218e-01 3 47088113 47088183 71 - 1.973 1.910 -0.213
ENSG00000181555 E034 95.3639804 0.0014493712 2.629708e-02 6.454453e-02 3 47088184 47088247 64 - 2.017 1.895 -0.408
ENSG00000181555 E035 161.9237068 0.0020469039 2.913651e-04 1.344626e-03 3 47097955 47098081 127 - 2.257 2.098 -0.534
ENSG00000181555 E036 0.8964071 0.1703004027 8.838254e-02 1.726486e-01 3 47098082 47099940 1859 - 0.387 0.000 -13.611
ENSG00000181555 E037 151.7687537 0.0056668790 5.931276e-04 2.508567e-03 3 47101458 47101555 98 - 2.236 2.048 -0.630
ENSG00000181555 E038 115.7387539 0.0048238632 3.476745e-02 8.120062e-02 3 47103346 47103423 78 - 2.101 1.972 -0.431
ENSG00000181555 E039 119.2176191 0.0072083135 1.296140e-01 2.336100e-01 3 47105997 47106120 124 - 2.106 2.000 -0.355
ENSG00000181555 E040 113.7551556 0.0019250540 3.263083e-02 7.705882e-02 3 47113876 47114004 129 - 2.090 1.976 -0.384
ENSG00000181555 E041 97.4318147 0.0006667433 1.079253e-05 7.116017e-05 3 47116623 47116754 132 - 2.051 1.846 -0.691
ENSG00000181555 E042 0.1472490 0.0429653362 1.000000e+00   3 47116755 47117013 259 - 0.093 0.000 -11.023
ENSG00000181555 E043 0.0000000       3 47119452 47119780 329 -      
ENSG00000181555 E044 129.6780453 0.0187383782 4.291026e-02 9.637488e-02 3 47120182 47120482 301 - 2.163 2.000 -0.547
ENSG00000181555 E045 658.3738208 0.0246222588 8.059541e-06 5.468094e-05 3 47120483 47122799 2317 - 2.911 2.585 -1.083
ENSG00000181555 E046 418.5444707 0.0174428287 1.752915e-18 9.370331e-17 3 47122800 47124548 1749 - 2.765 2.167 -1.994
ENSG00000181555 E047 29.5731020 0.0164780195 3.493305e-08 3.882641e-07 3 47126648 47126663 16 - 1.627 1.032 -2.084
ENSG00000181555 E048 0.1515154 0.0427780686 1.000000e+00   3 47163428 47163576 149 - 0.093 0.000 -11.023
ENSG00000181555 E049 33.1325231 0.0194008763 5.591221e-08 5.961169e-07 3 47163854 47164113 260 - 1.673 1.084 -2.053