ENSG00000181523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326317 ENSG00000181523 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSH protein_coding protein_coding 27.31166 33.30325 16.09119 3.329774 0.3834983 -1.048929 5.592910 8.627412 3.072553 0.8831441 0.37032954 -1.4864732 0.20773750 0.26820000 0.1900667 -0.07813333 0.4892929 7.438785e-05 FALSE  
ENST00000570923 ENSG00000181523 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSH protein_coding protein_coding 27.31166 33.30325 16.09119 3.329774 0.3834983 -1.048929 1.747343 1.675178 1.203969 0.5524873 0.04089485 -0.4731693 0.06830417 0.04896667 0.0750000 0.02603333 0.4931490 7.438785e-05 FALSE  
ENST00000571156 ENSG00000181523 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSH protein_coding processed_transcript 27.31166 33.30325 16.09119 3.329774 0.3834983 -1.048929 4.530916 8.303527 1.298961 1.6380933 0.92061461 -2.6670385 0.15114583 0.24776667 0.0784000 -0.16936667 0.3655400 7.438785e-05    
ENST00000573150 ENSG00000181523 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSH protein_coding nonsense_mediated_decay 27.31166 33.30325 16.09119 3.329774 0.3834983 -1.048929 7.042021 7.541189 4.174531 1.5174066 0.90106424 -0.8516378 0.25735417 0.22233333 0.2623333 0.04000000 0.8763036 7.438785e-05 FALSE  
ENST00000575282 ENSG00000181523 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSH protein_coding retained_intron 27.31166 33.30325 16.09119 3.329774 0.3834983 -1.048929 3.315688 3.077879 2.342123 0.5002828 0.05161938 -0.3926530 0.12505417 0.09140000 0.1458000 0.05440000 0.0193972 7.438785e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181523 E001 2.4681056 0.0064516380 7.814797e-01 8.595954e-01 17 80206716 80206808 93 - 0.514 0.492 -0.107
ENSG00000181523 E002 0.5514428 0.0196201651 2.717329e-01 4.105051e-01 17 80206809 80206828 20 - 0.000 0.231 11.329
ENSG00000181523 E003 0.5514428 0.0196201651 2.717329e-01 4.105051e-01 17 80206829 80206830 2 - 0.000 0.231 11.329
ENSG00000181523 E004 5.1627791 0.0031558349 7.999978e-01 8.724724e-01 17 80206831 80206978 148 - 0.706 0.771 0.266
ENSG00000181523 E005 5.7143367 0.0491682219 9.174127e-01 9.518445e-01 17 80206979 80207054 76 - 0.778 0.792 0.055
ENSG00000181523 E006 4.6569510 0.0262708225 1.761962e-01 2.962804e-01 17 80207597 80207604 8 - 0.514 0.774 1.124
ENSG00000181523 E007 5.6284847 0.0059698906 6.282801e-01 7.438507e-01 17 80207605 80207655 51 - 0.706 0.805 0.399
ENSG00000181523 E008 3.2504463 0.0047898685 3.710125e-01 5.154192e-01 17 80207656 80207685 30 - 0.665 0.553 -0.497
ENSG00000181523 E009 1.5855168 0.0666665323 3.313240e-02 7.806911e-02 17 80208162 80208218 57 - 0.000 0.462 12.327
ENSG00000181523 E010 0.8845503 0.3152257244 4.233408e-01 5.664008e-01 17 80209276 80209281 6 - 0.372 0.223 -1.015
ENSG00000181523 E011 1.0662547 0.0814007434 5.776255e-01 7.028539e-01 17 80209282 80209289 8 - 0.373 0.284 -0.559
ENSG00000181523 E012 85.4345644 0.0211171044 4.476442e-03 1.447552e-02 17 80209290 80209401 112 - 1.691 1.965 0.926
ENSG00000181523 E013 75.1201477 0.0155994861 2.636182e-03 9.178093e-03 17 80209402 80209405 4 - 1.640 1.909 0.910
ENSG00000181523 E014 718.1590009 0.0068434368 2.950851e-04 1.359839e-03 17 80209406 80210396 991 - 2.695 2.861 0.555
ENSG00000181523 E015 401.3519255 0.0012745733 2.073179e-01 3.352890e-01 17 80210397 80211011 615 - 2.514 2.583 0.228
ENSG00000181523 E016 58.0617276 0.0120434149 5.792574e-01 7.041968e-01 17 80211012 80211152 141 - 1.725 1.728 0.009
ENSG00000181523 E017 27.0909330 0.0010472762 7.612840e-01 8.451984e-01 17 80211153 80211187 35 - 1.391 1.404 0.045
ENSG00000181523 E018 94.9987260 0.0026838121 1.165724e-02 3.271744e-02 17 80211188 80211533 346 - 1.985 1.912 -0.247
ENSG00000181523 E019 79.3113883 0.0092106934 6.143431e-02 1.290476e-01 17 80211534 80211772 239 - 1.905 1.837 -0.228
ENSG00000181523 E020 23.2180828 0.0136128603 6.170432e-01 7.349318e-01 17 80211773 80211777 5 - 1.340 1.335 -0.015
ENSG00000181523 E021 50.5736029 0.0066978627 4.595020e-01 5.996349e-01 17 80211778 80211868 91 - 1.670 1.663 -0.026
ENSG00000181523 E022 41.9282737 0.0016228650 1.142799e-02 3.218228e-02 17 80211869 80211923 55 - 1.662 1.549 -0.383
ENSG00000181523 E023 33.5104384 0.0154026393 1.379446e-01 2.452141e-01 17 80211924 80211946 23 - 1.550 1.467 -0.286
ENSG00000181523 E024 52.6312553 0.0052692821 2.438535e-02 6.061368e-02 17 80211947 80212070 124 - 1.747 1.651 -0.328
ENSG00000181523 E025 136.4433043 0.0062990181 4.513375e-01 5.923061e-01 17 80212071 80212204 134 - 2.087 2.096 0.030
ENSG00000181523 E026 90.7860773 0.0159770116 5.703959e-01 6.968901e-01 17 80212205 80212274 70 - 1.917 1.922 0.016
ENSG00000181523 E027 37.3330862 0.0117333442 9.855906e-04 3.909652e-03 17 80212275 80213803 1529 - 1.674 1.463 -0.722
ENSG00000181523 E028 58.3323071 0.0317597920 7.861542e-01 8.630388e-01 17 80213804 80213820 17 - 1.714 1.740 0.085
ENSG00000181523 E029 54.5588135 0.0201531246 8.615130e-01 9.146807e-01 17 80213821 80213831 11 - 1.653 1.720 0.226
ENSG00000181523 E030 86.8646513 0.0061231308 7.157906e-01 8.116288e-01 17 80213832 80213885 54 - 1.882 1.905 0.077
ENSG00000181523 E031 25.0253949 0.0008204983 7.342369e-08 7.653314e-07 17 80213886 80214165 280 - 1.582 1.245 -1.165
ENSG00000181523 E032 7.4465208 0.0145886071 8.029151e-04 3.269607e-03 17 80214166 80214171 6 - 1.122 0.735 -1.465
ENSG00000181523 E033 94.3023065 0.0025869998 2.470300e-02 6.126899e-02 17 80214172 80214242 71 - 1.975 1.914 -0.206
ENSG00000181523 E034 68.4235307 0.0003953166 7.558937e-03 2.266819e-02 17 80214243 80214289 47 - 1.853 1.769 -0.284
ENSG00000181523 E035 61.8933625 0.0004547881 6.926459e-02 1.421477e-01 17 80214290 80214328 39 - 1.788 1.737 -0.172
ENSG00000181523 E036 3.6923202 0.0044017655 8.823395e-02 1.724255e-01 17 80214570 80214614 45 - 0.777 0.553 -0.956
ENSG00000181523 E037 76.7580506 0.0003557236 9.596198e-01 9.786297e-01 17 80214615 80214679 65 - 1.821 1.855 0.113
ENSG00000181523 E038 80.9799077 0.0028895423 7.038685e-01 8.024805e-01 17 80214680 80214765 86 - 1.858 1.877 0.063
ENSG00000181523 E039 5.2587267 0.0039643200 3.280960e-03 1.109447e-02 17 80214766 80214783 18 - 0.983 0.630 -1.398
ENSG00000181523 E040 12.6764624 0.0014205724 1.322853e-03 5.052938e-03 17 80214855 80215032 178 - 1.271 1.005 -0.957
ENSG00000181523 E041 62.2461804 0.0068524926 3.957926e-01 5.395804e-01 17 80215033 80215138 106 - 1.771 1.758 -0.046
ENSG00000181523 E042 9.6165033 0.0018631155 1.385460e-04 6.972223e-04 17 80216723 80217031 309 - 1.203 0.835 -1.356
ENSG00000181523 E043 83.0118839 0.0004154090 3.741578e-01 5.185794e-01 17 80217032 80217192 161 - 1.882 1.881 -0.005
ENSG00000181523 E044 1.3524590 0.3823158446 5.840744e-01 7.080721e-01 17 80217193 80217227 35 - 0.373 0.339 -0.203
ENSG00000181523 E045 46.4433095 0.0004721677 1.039120e-01 1.964651e-01 17 80220226 80220360 135 - 1.670 1.617 -0.180
ENSG00000181523 E046 0.0000000       17 80220882 80220923 42 -