ENSG00000181409

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326724 ENSG00000181409 HEK293_OSMI2_2hA HEK293_TMG_2hB AATK protein_coding protein_coding 1.426383 2.226026 1.132062 0.2125571 0.05092381 -0.9692954 0.77859326 1.14042135 0.74482928 0.10809775 0.04707707 -0.6079401 0.56191250 0.51316667 0.65843333 0.145266667 2.126824e-01 1.418495e-08 FALSE TRUE
ENST00000417379 ENSG00000181409 HEK293_OSMI2_2hA HEK293_TMG_2hB AATK protein_coding protein_coding 1.426383 2.226026 1.132062 0.2125571 0.05092381 -0.9692954 0.13172193 0.18382959 0.10664688 0.02441137 0.01664697 -0.7326411 0.11615417 0.08466667 0.09370000 0.009033333 9.065087e-01 1.418495e-08 FALSE TRUE
ENST00000570932 ENSG00000181409 HEK293_OSMI2_2hA HEK293_TMG_2hB AATK protein_coding nonsense_mediated_decay 1.426383 2.226026 1.132062 0.2125571 0.05092381 -0.9692954 0.25333150 0.69709945 0.00000000 0.02757633 0.00000000 -6.1438412 0.12080417 0.31963333 0.00000000 -0.319633333 1.418495e-08 1.418495e-08 TRUE TRUE
ENST00000572798 ENSG00000181409 HEK293_OSMI2_2hA HEK293_TMG_2hB AATK protein_coding processed_transcript 1.426383 2.226026 1.132062 0.2125571 0.05092381 -0.9692954 0.14470939 0.12876517 0.07984782 0.09512414 0.04007929 -0.6270901 0.08108333 0.05330000 0.06903333 0.015733333 9.074546e-01 1.418495e-08 FALSE FALSE
ENST00000575363 ENSG00000181409 HEK293_OSMI2_2hA HEK293_TMG_2hB AATK protein_coding protein_coding 1.426383 2.226026 1.132062 0.2125571 0.05092381 -0.9692954 0.04390299 0.05768037 0.11992020 0.05768037 0.05996244 0.9408164 0.03840833 0.02223333 0.10400000 0.081766667 4.719181e-01 1.418495e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181409 E001 29.7049565 0.0053258576 0.4785722597 0.6169848917 17 81110487 81117294 6808 - 1.479 1.427 -0.180
ENSG00000181409 E002 0.5848540 0.0330058740 0.2560016670 0.3929704563 17 81117295 81117297 3 - 0.000 0.228 10.464
ENSG00000181409 E003 53.9002302 0.0005667172 0.0001290873 0.0006548629 17 81117298 81117999 702 - 1.547 1.743 0.667
ENSG00000181409 E004 32.5548956 0.0008793622 0.0025766985 0.0089943029 17 81118000 81118322 323 - 1.329 1.531 0.697
ENSG00000181409 E005 22.3626937 0.0010112702 0.0008514444 0.0034429795 17 81118323 81118442 120 - 1.115 1.391 0.973
ENSG00000181409 E006 19.5062160 0.0080502266 0.0143745498 0.0390778097 17 81119380 81119580 201 - 1.099 1.330 0.816
ENSG00000181409 E007 13.0731292 0.0108565633 0.1860032298 0.3087483145 17 81119936 81120083 148 - 0.991 1.136 0.530
ENSG00000181409 E008 14.6650310 0.0013400505 0.2423045242 0.3768944965 17 81120201 81120399 199 - 1.066 1.176 0.395
ENSG00000181409 E009 22.4970745 0.0009038802 0.3157520852 0.4585252364 17 81120400 81120827 428 - 1.269 1.344 0.263
ENSG00000181409 E010 14.9267484 0.0016590077 0.2527347023 0.3891435329 17 81120828 81120984 157 - 1.083 1.189 0.379
ENSG00000181409 E011 17.0562404 0.0045044022 0.8298267993 0.8931814955 17 81120985 81121247 263 - 1.235 1.213 -0.077
ENSG00000181409 E012 34.2283561 0.0090684058 0.4003087753 0.5439952984 17 81121248 81122426 1179 - 1.541 1.482 -0.204
ENSG00000181409 E013 2.2101167 0.0097567176 0.0411859120 0.0932259689 17 81122427 81122508 82 - 0.672 0.332 -1.688
ENSG00000181409 E014 2.2874359 0.0079583858 0.0041019706 0.0134301024 17 81122509 81122534 26 - 0.750 0.283 -2.334
ENSG00000181409 E015 3.2505637 0.0318821500 0.0021528991 0.0076983818 17 81122535 81122618 84 - 0.874 0.377 -2.228
ENSG00000181409 E016 6.4182798 0.0026640407 0.0088688304 0.0259530315 17 81122619 81122732 114 - 1.030 0.710 -1.235
ENSG00000181409 E017 5.9452110 0.0028811247 0.0401057394 0.0912289518 17 81122733 81122823 91 - 0.970 0.710 -1.013
ENSG00000181409 E018 10.0862943 0.0019121334 0.3605081979 0.5048281929 17 81123194 81123343 150 - 1.066 0.966 -0.366
ENSG00000181409 E019 9.9453786 0.0017971506 0.0248457440 0.0615569432 17 81124727 81124848 122 - 1.144 0.909 -0.866
ENSG00000181409 E020 6.1485730 0.0027191325 0.0349624010 0.0815845340 17 81124930 81124961 32 - 0.991 0.728 -1.014
ENSG00000181409 E021 7.1052562 0.0024878868 0.0490141695 0.1074074327 17 81124962 81125014 53 - 1.030 0.797 -0.883
ENSG00000181409 E022 5.7015390 0.0030389172 0.5470285347 0.6771180321 17 81126427 81126445 19 - 0.846 0.764 -0.321
ENSG00000181409 E023 7.1763435 0.0025194734 0.1402242387 0.2483266737 17 81126446 81126560 115 - 0.991 0.813 -0.676
ENSG00000181409 E024 0.2998086 0.0290770104 0.6098652475   17 81126658 81126817 160 - 0.165 0.089 -1.016
ENSG00000181409 E025 7.7643023 0.0022057450 0.7569160871 0.8418883902 17 81127583 81127670 88 - 0.874 0.909 0.134
ENSG00000181409 E026 5.6941495 0.0030389172 0.7156309816 0.8115083100 17 81127792 81127852 61 - 0.750 0.797 0.189
ENSG00000181409 E027 8.1780374 0.0021448474 0.5405250605 0.6716615689 17 81127853 81127910 58 - 0.970 0.896 -0.276
ENSG00000181409 E028 9.6644953 0.0018857778 0.2652977300 0.4033372848 17 81128470 81128549 80 - 1.066 0.944 -0.449
ENSG00000181409 E029 0.1515154 0.0437009192 0.2452074819   17 81128550 81128683 134 - 0.165 0.000 -11.220
ENSG00000181409 E030 0.3332198 0.0285060130 0.6109586298   17 81128684 81128925 242 - 0.165 0.090 -1.013
ENSG00000181409 E031 11.5725527 0.0017030132 0.0953729290 0.1834549924 17 81131061 81131205 145 - 1.172 1.007 -0.599
ENSG00000181409 E032 0.4751703 0.0221779669 1.0000000000 1.0000000000 17 81131902 81131948 47 - 0.165 0.164 -0.015
ENSG00000181409 E033 0.3289534 0.0286747664 0.6124250159   17 81132656 81132847 192 - 0.165 0.090 -1.013
ENSG00000181409 E034 6.2730330 0.0028124984 0.0215873032 0.0548239830 17 81134368 81134501 134 - 1.011 0.728 -1.088
ENSG00000181409 E035 1.1373435 0.0199555477 0.6042162261 0.7248230249 17 81165682 81165814 133 - 0.378 0.282 -0.599
ENSG00000181409 E036 1.7650377 0.0095696919 0.0004243274 0.0018676537 17 81165938 81166221 284 - 0.750 0.164 -3.337