ENSG00000181191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361478 ENSG00000181191 HEK293_OSMI2_2hA HEK293_TMG_2hB PJA1 protein_coding protein_coding 22.11392 23.80469 24.87788 2.478919 0.07530412 0.06359116 1.761238 2.256255 1.698234 0.4457854 0.2992151 -0.4078046 0.0806750 0.09370000 0.0682 -0.0255000 5.298719e-01 3.467103e-10 FALSE TRUE
ENST00000374571 ENSG00000181191 HEK293_OSMI2_2hA HEK293_TMG_2hB PJA1 protein_coding protein_coding 22.11392 23.80469 24.87788 2.478919 0.07530412 0.06359116 16.350372 18.763725 16.816901 1.6352766 0.5996476 -0.1579454 0.7403833 0.79113333 0.6761 -0.1150333 4.153300e-02 3.467103e-10 FALSE TRUE
ENST00000477231 ENSG00000181191 HEK293_OSMI2_2hA HEK293_TMG_2hB PJA1 protein_coding processed_transcript 22.11392 23.80469 24.87788 2.478919 0.07530412 0.06359116 1.840432 0.739567 3.842546 0.1993775 0.3393711 2.3616828 0.0823000 0.03006667 0.1544 0.1243333 3.467103e-10 3.467103e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000181191 E001 0.8082883 0.0158036138 2.992533e-02 7.181556e-02 X 69160851 69160853 3 - 0.000 0.392 10.458
ENSG00000181191 E002 2.5702160 0.0062256571 9.313157e-01 9.607484e-01 X 69160854 69160860 7 - 0.547 0.562 0.070
ENSG00000181191 E003 4.1200720 0.0078368562 3.136937e-01 4.563091e-01 X 69160861 69160861 1 - 0.627 0.777 0.621
ENSG00000181191 E004 233.1020993 0.0011897894 1.829794e-04 8.906697e-04 X 69160862 69161244 383 - 2.303 2.407 0.347
ENSG00000181191 E005 398.2616493 0.0001670070 2.319617e-12 5.363657e-11 X 69161245 69161684 440 - 2.521 2.646 0.416
ENSG00000181191 E006 298.8833452 0.0001982860 3.417513e-04 1.547191e-03 X 69161685 69161943 259 - 2.428 2.503 0.249
ENSG00000181191 E007 113.8012695 0.0017804704 1.426372e-01 2.516293e-01 X 69161944 69162020 77 - 2.020 2.075 0.184
ENSG00000181191 E008 108.2930615 0.0003099106 8.208229e-02 1.628127e-01 X 69162021 69162047 27 - 1.997 2.059 0.207
ENSG00000181191 E009 288.1958288 0.0002116351 9.827709e-01 9.932991e-01 X 69162048 69162325 278 - 2.457 2.459 0.008
ENSG00000181191 E010 140.8284566 0.0002853345 2.771901e-01 4.167024e-01 X 69162326 69162381 56 - 2.167 2.137 -0.100
ENSG00000181191 E011 202.2465215 0.0002729135 4.589125e-02 1.018398e-01 X 69162382 69162544 163 - 2.331 2.283 -0.160
ENSG00000181191 E012 241.2759793 0.0002883939 3.814771e-02 8.763469e-02 X 69162545 69162804 260 - 2.406 2.360 -0.153
ENSG00000181191 E013 193.0706392 0.0002270983 1.321255e-03 5.047853e-03 X 69162805 69162945 141 - 2.330 2.252 -0.262
ENSG00000181191 E014 217.7384134 0.0002098309 3.644646e-10 5.850922e-09 X 69162946 69163134 189 - 2.417 2.271 -0.485
ENSG00000181191 E015 62.9565277 0.0044884451 3.792836e-03 1.256169e-02 X 69163135 69163140 6 - 1.888 1.730 -0.533
ENSG00000181191 E016 29.9062620 0.0007112503 7.105446e-01 8.076955e-01 X 69163141 69163298 158 - 1.500 1.479 -0.072
ENSG00000181191 E017 23.5859527 0.0163211386 9.246763e-01 9.565674e-01 X 69163299 69163466 168 - 1.394 1.385 -0.031
ENSG00000181191 E018 1.7253074 0.0120809748 5.286025e-01 6.615152e-01 X 69163467 69163545 79 - 0.500 0.393 -0.556
ENSG00000181191 E019 94.4235758 0.0003414068 6.074774e-09 7.808181e-08 X 69165372 69165521 150 - 2.088 1.881 -0.695