ENSG00000180957

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335272 ENSG00000180957 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNB protein_coding protein_coding 75.59446 45.28957 120.0053 1.271262 3.756998 1.405649 52.33170 41.89837 67.82313 0.9083296 2.837203 0.6947517 0.7685250 0.9255333 0.5650000 -0.3605333 1.883131e-29 8.965151e-96 FALSE TRUE
MSTRG.21872.1 ENSG00000180957 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNB protein_coding   75.59446 45.28957 120.0053 1.271262 3.756998 1.405649 17.56485 0.00000 41.58758 0.0000000 1.517313 12.0222840 0.1542792 0.0000000 0.3469333 0.3469333 8.965151e-96 8.965151e-96 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180957 E001 0.2214452 0.0401432068 2.297223e-01   22 27806580 27806619 40 - 0.000 0.184 9.903
ENSG00000180957 E002 2.3560429 0.1010735151 1.200983e-02 3.355493e-02 22 27851669 27851669 1 - 0.256 0.823 2.817
ENSG00000180957 E003 2974.6660402 0.0062536702 2.259862e-14 7.055438e-13 22 27851670 27853524 1855 - 3.322 3.625 1.009
ENSG00000180957 E004 268.5820338 0.0022516115 4.299722e-01 5.725980e-01 22 27853525 27853578 54 - 2.375 2.443 0.225
ENSG00000180957 E005 449.4922282 0.0002081315 2.431346e-02 6.046114e-02 22 27853579 27853663 85 - 2.603 2.655 0.173
ENSG00000180957 E006 378.8793156 0.0001602786 6.863143e-02 1.410932e-01 22 27854854 27854905 52 - 2.528 2.586 0.193
ENSG00000180957 E007 406.3840714 0.0025233741 5.075355e-03 1.613652e-02 22 27854906 27854939 34 - 2.574 2.583 0.027
ENSG00000180957 E008 498.6632498 0.0016388153 4.316341e-06 3.115472e-05 22 27858387 27858430 44 - 2.673 2.649 -0.081
ENSG00000180957 E009 554.0787258 0.0017106183 7.978362e-08 8.259887e-07 22 27858431 27858509 79 - 2.725 2.682 -0.142
ENSG00000180957 E010 429.5086126 0.0015636797 5.453175e-04 2.329345e-03 22 27860131 27860195 65 - 2.600 2.603 0.010
ENSG00000180957 E011 337.6177348 0.0023868157 4.733030e-04 2.058066e-03 22 27860196 27860241 46 - 2.502 2.487 -0.052
ENSG00000180957 E012 1.2878016 0.0101793403 7.487633e-01 8.359024e-01 22 27860242 27860615 374 - 0.302 0.412 0.658
ENSG00000180957 E013 342.4429735 0.0019738414 9.234921e-07 7.719755e-06 22 27873738 27873774 37 - 2.519 2.466 -0.176
ENSG00000180957 E014 321.0193079 0.0004811123 2.057841e-08 2.393371e-07 22 27873775 27873815 41 - 2.487 2.448 -0.128
ENSG00000180957 E015 3.5576312 0.0217679942 2.328795e-01 3.658484e-01 22 27894161 27894554 394 - 0.533 0.797 1.130
ENSG00000180957 E016 393.5102999 0.0001356146 5.010168e-07 4.430571e-06 22 27894555 27894638 84 - 2.565 2.561 -0.013
ENSG00000180957 E017 350.9422718 0.0001743493 8.367949e-08 8.628799e-07 22 27896552 27896626 75 - 2.521 2.503 -0.060
ENSG00000180957 E018 4.8112217 0.0058071654 2.541177e-01 3.907585e-01 22 27896627 27896702 76 - 0.765 0.672 -0.383
ENSG00000180957 E019 5.9316002 0.0028162466 6.808257e-01 7.846715e-01 22 27896900 27897129 230 - 0.807 0.833 0.099
ENSG00000180957 E020 222.0267111 0.0001920774 6.967623e-11 1.262429e-09 22 27897130 27897137 8 - 2.340 2.260 -0.265
ENSG00000180957 E021 395.3506934 0.0001356460 3.024380e-08 3.401566e-07 22 27897801 27897892 92 - 2.570 2.556 -0.048
ENSG00000180957 E022 1.4371390 0.0096005920 1.539081e-01 2.669859e-01 22 27897893 27898073 181 - 0.256 0.561 1.716
ENSG00000180957 E023 1.9425999 0.0119224547 2.076557e-01 3.356634e-01 22 27910448 27910963 516 - 0.343 0.620 1.395
ENSG00000180957 E024 564.2180962 0.0001649072 2.900769e-13 7.723711e-12 22 27910964 27911109 146 - 2.728 2.700 -0.095
ENSG00000180957 E025 337.5875258 0.0016936529 2.587162e-06 1.964843e-05 22 27914317 27914347 31 - 2.509 2.467 -0.143
ENSG00000180957 E026 5.2380802 0.0030703141 1.399898e-01 2.480142e-01 22 27919102 27919171 70 - 0.807 0.672 -0.553
ENSG00000180957 E027 291.3570101 0.0002341894 1.803857e-09 2.547892e-08 22 27919172 27919256 85 - 2.447 2.400 -0.157
ENSG00000180957 E028 4.6368792 0.0041409468 5.881219e-02 1.246015e-01 22 27919811 27920134 324 - 0.779 0.561 -0.927