ENSG00000180921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000388913 ENSG00000180921 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM83H protein_coding protein_coding 5.731422 8.559687 6.054274 0.8291651 0.05308218 -0.4989077 4.6212358 7.9136008 3.835354 0.5832455 0.087360 -1.043040 0.7759750 0.9310 0.6334000 -0.2976000 0.007277012 0.007277012 FALSE TRUE
MSTRG.32222.5 ENSG00000180921 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM83H protein_coding   5.731422 8.559687 6.054274 0.8291651 0.05308218 -0.4989077 0.8727227 0.3931952 1.829544 0.3931952 0.139888 2.189798 0.1811917 0.0404 0.3024333 0.2620333 0.053703971 0.007277012 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180921 E001 0.4448795 0.569418158 5.354866e-01 6.673047e-01 8 143723933 143723933 1 - 0.001 0.217 9.134
ENSG00000180921 E002 162.1227347 0.017632547 1.915372e-05 1.193427e-04 8 143723934 143724354 421 - 1.918 2.245 1.097
ENSG00000180921 E003 279.3883540 0.005656073 3.512942e-07 3.204065e-06 8 143724355 143725450 1096 - 2.236 2.461 0.753
ENSG00000180921 E004 488.6933268 0.001954297 6.566830e-03 2.009995e-02 8 143725451 143728723 3273 - 2.656 2.642 -0.048
ENSG00000180921 E005 57.9139937 0.006004917 2.475523e-03 8.690132e-03 8 143728967 143729091 125 - 1.821 1.677 -0.487
ENSG00000180921 E006 74.4222249 0.027731127 4.194904e-02 9.463447e-02 8 143729159 143729323 165 - 1.922 1.792 -0.440
ENSG00000180921 E007 121.0440237 0.005097666 2.405995e-05 1.465481e-04 8 143730136 143730597 462 - 2.144 1.993 -0.507
ENSG00000180921 E008 14.6193465 0.001391370 9.739625e-03 2.812246e-02 8 143732661 143732734 74 - 1.277 1.073 -0.725
ENSG00000180921 E009 15.6070524 0.001240697 1.380488e-03 5.242413e-03 8 143732831 143732965 135 - 1.336 1.090 -0.872
ENSG00000180921 E010 16.3832779 0.001142631 6.509722e-04 2.719279e-03 8 143733691 143733917 227 - 1.363 1.106 -0.908
ENSG00000180921 E011 0.0000000       8 143737647 143738234 588 -