ENSG00000180917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338099 ENSG00000180917 HEK293_OSMI2_2hA HEK293_TMG_2hB CMTR2 protein_coding protein_coding 2.789232 0.681552 4.915548 0.1270968 0.07168927 2.832375 0.4175372 0.39668387 0.4320789 0.20281683 0.43207889 0.1203961 0.28843333 0.54830000 0.08550000 -0.46280000 0.29551464 0.01353581 FALSE  
ENST00000434935 ENSG00000180917 HEK293_OSMI2_2hA HEK293_TMG_2hB CMTR2 protein_coding protein_coding 2.789232 0.681552 4.915548 0.1270968 0.07168927 2.832375 1.5409592 0.21350265 2.9732200 0.13263651 0.44253229 3.7385065 0.44127917 0.34306667 0.60760000 0.26453333 0.52341939 0.01353581 FALSE  
ENST00000564690 ENSG00000180917 HEK293_OSMI2_2hA HEK293_TMG_2hB CMTR2 protein_coding retained_intron 2.789232 0.681552 4.915548 0.1270968 0.07168927 2.832375 0.5145004 0.05665266 0.8243655 0.01757026 0.04675343 3.6459451 0.19177083 0.09293333 0.16760000 0.07466667 0.33314511 0.01353581    
MSTRG.12936.7 ENSG00000180917 HEK293_OSMI2_2hA HEK293_TMG_2hB CMTR2 protein_coding   2.789232 0.681552 4.915548 0.1270968 0.07168927 2.832375 0.2091081 0.00000000 0.4854067 0.00000000 0.04767730 5.6305415 0.04084583 0.00000000 0.09906667 0.09906667 0.01353581 0.01353581    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180917 E001 0.000000       16 71281389 71281391 3 -      
ENSG00000180917 E002 212.871205 0.0252607575 7.717499e-05 0.0004146856 16 71281392 71285441 4050 - 2.102 2.390 0.963
ENSG00000180917 E003 9.659799 0.0114911254 1.263420e-02 0.0350487140 16 71285442 71285444 3 - 0.895 0.588 -1.252
ENSG00000180917 E004 16.024705 0.0105287587 7.219864e-02 0.1469989906 16 71285445 71285523 79 - 1.073 0.983 -0.327
ENSG00000180917 E005 14.806528 0.0476658926 6.449691e-01 0.7571929522 16 71285524 71285604 81 - 1.021 1.097 0.278
ENSG00000180917 E006 10.409443 0.0098585534 3.034108e-01 0.4453211271 16 71285605 71285649 45 - 0.895 0.887 -0.029
ENSG00000180917 E007 21.252383 0.0067649330 6.895873e-02 0.1416476862 16 71285650 71285939 290 - 1.180 1.129 -0.184
ENSG00000180917 E008 26.619686 0.0009016757 3.690423e-04 0.0016543377 16 71286460 71288555 2096 - 1.286 1.062 -0.798
ENSG00000180917 E009 4.924107 0.0033261592 2.667813e-02 0.0653202925 16 71288556 71288675 120 - 0.657 0.292 -1.883
ENSG00000180917 E010 4.325304 0.0623891746 6.613303e-01 0.7698008720 16 71288676 71288877 202 - 0.575 0.591 0.072
ENSG00000180917 E011 8.158764 0.0020979161 7.382247e-01 0.8281585830 16 71288878 71288937 60 - 0.792 0.887 0.370
ENSG00000180917 E012 3.398950 0.0046923922 1.130228e-01 0.2099528298 16 71289086 71289135 50 - 0.535 0.292 -1.343
ENSG00000180917 E013 13.846752 0.0013675981 1.518376e-02 0.0409043629 16 71289136 71289351 216 - 1.021 0.829 -0.724
ENSG00000180917 E014 5.917385 0.0028449516 5.973653e-02 0.1261737870 16 71289352 71289609 258 - 0.707 0.465 -1.092
ENSG00000180917 E015 0.000000       16 71289687 71289715 29 -