ENSG00000180900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320476 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding protein_coding 68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 28.073887 39.3930339 20.0841844 6.4973241 0.70024335 -0.97152870 0.42352083 0.390200000 0.46823333 0.078033333 5.978463e-01 1.362797e-17 FALSE TRUE
ENST00000356994 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding protein_coding 68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 4.189787 5.3334639 3.0667900 0.4996005 0.30089205 -0.79634927 0.06500417 0.053066667 0.07123333 0.018166667 2.440666e-01 1.362797e-17 FALSE TRUE
ENST00000377533 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding protein_coding 68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 6.793333 15.0845947 0.8321781 2.2958790 0.60242709 -4.16376292 0.08239167 0.149933333 0.01846667 -0.131466667 9.326739e-02 1.362797e-17 FALSE TRUE
ENST00000531163 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding retained_intron 68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 11.206018 16.7691757 7.3934540 0.9153270 0.82541086 -1.18040143 0.16593750 0.168333333 0.17110000 0.002766667 9.939338e-01 1.362797e-17   FALSE
ENST00000531942 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding protein_coding 68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 4.519423 3.9349853 4.0480350 1.9704969 0.79125908 0.04076137 0.07421667 0.038466667 0.09500000 0.056533333 6.323205e-01 1.362797e-17 FALSE FALSE
MSTRG.32228.11 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding   68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 3.882108 12.0569157 0.4474845 1.8553674 0.04589886 -4.72119032 0.04040417 0.120666667 0.01033333 -0.110333333 7.189650e-15 1.362797e-17 FALSE TRUE
MSTRG.32228.12 ENSG00000180900 HEK293_OSMI2_2hA HEK293_TMG_2hB SCRIB protein_coding   68.27866 100.4181 43.05194 6.50583 1.461008 -1.221678 1.622208 0.7693544 2.7367765 0.7693544 0.33702314 1.81738819 0.03087500 0.008066667 0.06353333 0.055466667 6.120681e-02 1.362797e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180900 E001 0.0000000       8 143790788 143790919 132 -      
ENSG00000180900 E002 0.3299976 0.0279431363 6.407725e-01   8 143790920 143790924 5 - 0.000 0.145 9.681
ENSG00000180900 E003 6.5815506 0.0249686582 9.059832e-06 6.081201e-05 8 143790925 143790925 1 - 0.000 0.929 13.896
ENSG00000180900 E004 7.2029258 0.0260374011 3.173730e-03 1.077805e-02 8 143790926 143790933 8 - 0.415 0.939 2.268
ENSG00000180900 E005 12.3030366 0.0201590596 2.009834e-01 3.274006e-01 8 143790934 143790935 2 - 0.927 1.101 0.641
ENSG00000180900 E006 54.2484344 0.0193623319 4.209715e-02 9.490740e-02 8 143790936 143790964 29 - 1.518 1.714 0.669
ENSG00000180900 E007 733.9991579 0.0055867031 2.833837e-05 1.695335e-04 8 143790965 143791308 344 - 2.654 2.831 0.589
ENSG00000180900 E008 357.8205004 0.0046593586 1.460985e-03 5.510238e-03 8 143791389 143791440 52 - 2.374 2.512 0.461
ENSG00000180900 E009 53.5093013 0.0006082681 1.527308e-13 4.227083e-12 8 143791441 143791542 102 - 1.905 1.540 -1.238
ENSG00000180900 E010 45.3205126 0.0004942366 1.707475e-03 6.305575e-03 8 143791666 143791740 75 - 1.717 1.547 -0.580
ENSG00000180900 E011 252.9387967 0.0127652603 2.608443e-03 9.089871e-03 8 143791876 143791913 38 - 2.176 2.373 0.659
ENSG00000180900 E012 400.0234114 0.0029549544 1.635267e-05 1.034655e-04 8 143791991 143792133 143 - 2.405 2.563 0.528
ENSG00000180900 E013 504.0073196 0.0001530090 9.723645e-10 1.445250e-08 8 143792220 143792401 182 - 2.524 2.652 0.426
ENSG00000180900 E014 209.9253903 0.0025421078 4.900180e-05 2.767243e-04 8 143792402 143792405 4 - 2.112 2.282 0.568
ENSG00000180900 E015 536.1001966 0.0003949874 1.086786e-10 1.907243e-09 8 143792485 143792608 124 - 2.539 2.682 0.476
ENSG00000180900 E016 396.5546930 0.0001296194 3.604008e-10 5.789608e-09 8 143792609 143792635 27 - 2.407 2.552 0.485
ENSG00000180900 E017 8.0614750 0.0052875044 1.553272e-03 5.808809e-03 8 143792636 143792707 72 - 1.139 0.776 -1.363
ENSG00000180900 E018 698.8326669 0.0010603489 1.216643e-09 1.773541e-08 8 143792708 143792867 160 - 2.655 2.802 0.490
ENSG00000180900 E019 545.8328178 0.0023913239 2.580510e-04 1.208758e-03 8 143792976 143793083 108 - 2.571 2.691 0.398
ENSG00000180900 E020 11.5540232 0.0035136918 8.183738e-07 6.924142e-06 8 143793084 143793256 173 - 1.348 0.867 -1.745
ENSG00000180900 E021 8.0822007 0.0020149359 1.215715e-03 4.693765e-03 8 143793257 143793340 84 - 1.139 0.776 -1.363
ENSG00000180900 E022 21.5656849 0.0009564967 8.174488e-13 2.035799e-11 8 143793341 143793588 248 - 1.612 1.084 -1.842
ENSG00000180900 E023 411.0812695 0.0003584019 1.623197e-06 1.287837e-05 8 143793900 143793962 63 - 2.447 2.564 0.388
ENSG00000180900 E024 3.2712883 0.0157824210 3.142705e-03 1.068552e-02 8 143794079 143794236 158 - 0.869 0.414 -2.003
ENSG00000180900 E025 428.4321995 0.0004691664 8.864031e-10 1.327062e-08 8 143795038 143795112 75 - 2.438 2.589 0.502
ENSG00000180900 E026 472.0224624 0.0014770111 4.043481e-04 1.791369e-03 8 143795277 143795333 57 - 2.519 2.624 0.350
ENSG00000180900 E027 588.7941991 0.0010007651 2.878874e-04 1.330651e-03 8 143795420 143795530 111 - 2.624 2.717 0.310
ENSG00000180900 E028 569.9924055 0.0001282418 1.416476e-09 2.041750e-08 8 143803383 143803571 189 - 2.587 2.705 0.394
ENSG00000180900 E029 773.5856090 0.0000858780 3.503264e-11 6.670180e-10 8 143803647 143803940 294 - 2.725 2.835 0.367
ENSG00000180900 E030 572.5629510 0.0002426176 3.064085e-03 1.045536e-02 8 143804046 143804156 111 - 2.631 2.694 0.210
ENSG00000180900 E031 702.7476205 0.0003443892 8.200848e-02 1.626902e-01 8 143804568 143804825 258 - 2.739 2.779 0.131
ENSG00000180900 E032 154.3201652 0.0022042560 5.399374e-02 1.162566e-01 8 143804934 143804954 21 - 2.042 2.132 0.300
ENSG00000180900 E033 230.8312356 0.0042444807 2.894107e-01 4.300939e-01 8 143804955 143805014 60 - 2.242 2.302 0.201
ENSG00000180900 E034 355.9467334 0.0095045791 4.662893e-01 6.058620e-01 8 143805112 143805251 140 - 2.435 2.493 0.191
ENSG00000180900 E035 521.8680134 0.0021922943 2.154522e-01 3.449635e-01 8 143805252 143805435 184 - 2.606 2.655 0.163
ENSG00000180900 E036 397.6006152 0.0001407928 5.691490e-01 6.957572e-01 8 143806407 143806484 78 - 2.508 2.527 0.062
ENSG00000180900 E037 516.9672984 0.0001732441 9.410108e-01 9.669077e-01 8 143806924 143807013 90 - 2.633 2.639 0.018
ENSG00000180900 E038 359.2464368 0.0007625746 6.767621e-01 7.816382e-01 8 143807552 143807614 63 - 2.480 2.478 -0.005
ENSG00000180900 E039 1031.1071543 0.0004087250 2.343887e-02 5.865816e-02 8 143808609 143809025 417 - 2.957 2.931 -0.085
ENSG00000180900 E040 549.5203552 0.0002113076 7.978704e-07 6.766682e-06 8 143809551 143809718 168 - 2.724 2.643 -0.272
ENSG00000180900 E041 448.9882098 0.0001368364 1.337049e-04 6.754306e-04 8 143810479 143810604 126 - 2.626 2.558 -0.224
ENSG00000180900 E042 492.1842175 0.0001387691 1.169928e-04 6.000793e-04 8 143810686 143810816 131 - 2.664 2.599 -0.216
ENSG00000180900 E043 589.0408174 0.0009431797 1.922331e-04 9.305848e-04 8 143810906 143811072 167 - 2.748 2.677 -0.237
ENSG00000180900 E044 641.9808394 0.0005162026 4.740265e-17 2.118492e-15 8 143811146 143811345 200 - 2.838 2.692 -0.486
ENSG00000180900 E045 461.2985572 0.0001486000 3.473279e-15 1.223735e-13 8 143812266 143812384 119 - 2.691 2.551 -0.468
ENSG00000180900 E046 507.0213523 0.0024462226 2.906901e-06 2.181696e-05 8 143812817 143812956 140 - 2.726 2.599 -0.423
ENSG00000180900 E047 231.3596079 0.0002403756 1.479152e-08 1.766840e-07 8 143812957 143812961 5 - 2.393 2.251 -0.475
ENSG00000180900 E048 6.9299829 0.0029325753 1.919514e-04 9.294469e-04 8 143812962 143813029 68 - 1.122 0.679 -1.696
ENSG00000180900 E049 383.5338970 0.0008905513 1.982016e-12 4.627643e-11 8 143813030 143813104 75 - 2.627 2.465 -0.539
ENSG00000180900 E050 370.5542253 0.0007763609 3.608605e-14 1.093123e-12 8 143813311 143813374 64 - 2.620 2.448 -0.574
ENSG00000180900 E051 338.1753632 0.0017085506 6.248494e-09 8.012443e-08 8 143813470 143813526 57 - 2.571 2.413 -0.526
ENSG00000180900 E052 408.7536341 0.0007342997 1.743041e-15 6.389588e-14 8 143813637 143813726 90 - 2.661 2.489 -0.575
ENSG00000180900 E053 345.5869647 0.0002633540 1.498367e-18 8.080307e-17 8 143813818 143813896 79 - 2.596 2.412 -0.613
ENSG00000180900 E054 304.4746544 0.0001906079 1.702978e-12 4.016310e-11 8 143814001 143814118 118 - 2.519 2.365 -0.515
ENSG00000180900 E055 0.8147077 0.0970528147 2.277569e-02 5.728073e-02 8 143814832 143815213 382 - 0.496 0.079 -3.412
ENSG00000180900 E056 224.7815971 0.0063431347 2.127074e-06 1.644699e-05 8 143815214 143815797 584 - 2.426 2.222 -0.683