ENSG00000180891

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407144 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding protein_coding 19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 1.5669003 0.000000 1.8948227 0.0000000 0.1391628 7.5735129 0.10841250 0.00000000 0.13510000 0.1351000000 2.197901e-28 2.197901e-28 FALSE TRUE
ENST00000577830 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding protein_coding 19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 6.2791511 12.940103 3.7133062 0.6627902 0.3108102 -1.7983074 0.27910000 0.40856667 0.26200000 -0.1465666667 8.940247e-04 2.197901e-28 FALSE TRUE
ENST00000577840 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding protein_coding 19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 1.3795699 2.677478 1.2483793 0.6087773 0.6557892 -1.0946862 0.07487500 0.08240000 0.08306667 0.0006666667 8.910545e-01 2.197901e-28 FALSE TRUE
ENST00000578357 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding processed_transcript 19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 2.9395040 7.228615 2.1522021 0.3922794 0.4834120 -1.7432123 0.13931250 0.22873333 0.14966667 -0.0790666667 2.440394e-01 2.197901e-28   FALSE
ENST00000582951 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding retained_intron 19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 1.2098217 1.222947 0.7740389 0.3951173 0.3054787 -0.6531135 0.06684583 0.03916667 0.05426667 0.0151000000 8.941478e-01 2.197901e-28   FALSE
ENST00000584746 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding retained_intron 19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 3.5356980 4.508561 2.3388784 0.3521690 0.1989378 -0.9438913 0.19648333 0.14183333 0.16693333 0.0251000000 6.998854e-01 2.197901e-28 TRUE FALSE
MSTRG.14740.9 ENSG00000180891 HEK293_OSMI2_2hA HEK293_TMG_2hB CUEDC1 protein_coding   19.40705 31.81274 14.21187 2.397451 0.8402041 -1.161947 0.5613099 0.000000 1.0946835 0.0000000 0.5491982 6.7874893 0.03623333 0.00000000 0.07733333 0.0773333333 1.137116e-01 2.197901e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180891 E001 7.138659 0.0060219171 4.209887e-01 5.641582e-01 17 57861243 57861603 361 - 0.750 0.870 0.474
ENSG00000180891 E002 482.665301 0.0027297784 1.821506e-08 2.139758e-07 17 57861604 57862695 1092 - 2.482 2.658 0.586
ENSG00000180891 E003 189.735477 0.0101883536 1.829113e-02 4.776620e-02 17 57862696 57862874 179 - 2.106 2.249 0.480
ENSG00000180891 E004 83.799507 0.0224082055 2.765619e-01 4.160171e-01 17 57862875 57862914 40 - 1.792 1.890 0.331
ENSG00000180891 E005 90.650207 0.0003182437 4.345442e-03 1.411019e-02 17 57862915 57862962 48 - 1.793 1.927 0.453
ENSG00000180891 E006 66.746024 0.0004073966 2.802027e-02 6.805409e-02 17 57862963 57862975 13 - 1.669 1.790 0.411
ENSG00000180891 E007 261.375436 0.0001805461 4.228230e-03 1.378053e-02 17 57862976 57863271 296 - 2.289 2.370 0.272
ENSG00000180891 E008 94.230307 0.0003103044 1.174830e-01 2.163501e-01 17 57863272 57863285 14 - 1.856 1.932 0.254
ENSG00000180891 E009 5.780990 0.0168811899 4.409109e-01 5.825523e-01 17 57863286 57863357 72 - 0.662 0.792 0.533
ENSG00000180891 E010 152.478991 0.0002234850 7.627283e-01 8.462763e-01 17 57866474 57866544 71 - 2.120 2.120 0.001
ENSG00000180891 E011 58.284195 0.0017980634 1.600340e-04 7.919637e-04 17 57866545 57867240 696 - 1.837 1.652 -0.627
ENSG00000180891 E012 19.074157 0.0498295498 2.049515e-01 3.323471e-01 17 57867241 57867356 116 - 1.354 1.191 -0.572
ENSG00000180891 E013 123.461613 0.0002476445 2.488358e-01 3.845687e-01 17 57867357 57867415 59 - 2.051 2.020 -0.103
ENSG00000180891 E014 21.792670 0.0009049574 2.467145e-03 8.665380e-03 17 57867416 57867630 215 - 1.450 1.228 -0.775
ENSG00000180891 E015 170.591616 0.0011971728 1.134295e-02 3.198462e-02 17 57868150 57868243 94 - 2.218 2.146 -0.240
ENSG00000180891 E016 1.619975 0.0086517303 7.416520e-01 8.307244e-01 17 57868244 57868465 222 - 0.405 0.350 -0.312
ENSG00000180891 E017 136.987333 0.0020966981 2.663354e-01 4.045156e-01 17 57869122 57869193 72 - 2.094 2.063 -0.104
ENSG00000180891 E018 1.957351 0.0073644080 3.324351e-04 1.510139e-03 17 57869897 57869938 42 - 0.788 0.209 -3.052
ENSG00000180891 E019 116.211879 0.0018641649 7.999123e-02 1.595448e-01 17 57871286 57871369 84 - 2.047 1.987 -0.201
ENSG00000180891 E020 160.457117 0.0002386169 2.112791e-01 3.400032e-01 17 57872663 57872810 148 - 2.162 2.133 -0.096
ENSG00000180891 E021 103.458315 0.0003457352 8.784409e-01 9.259187e-01 17 57872811 57872855 45 - 1.941 1.956 0.053
ENSG00000180891 E022 143.826239 0.0003186969 1.560894e-02 4.186581e-02 17 57873591 57873717 127 - 2.145 2.076 -0.230
ENSG00000180891 E023 121.253156 0.0006740021 1.895060e-02 4.922510e-02 17 57879611 57879738 128 - 2.077 2.002 -0.251
ENSG00000180891 E024 2.285255 0.0064516380 8.422443e-01 9.016732e-01 17 57885172 57885228 57 - 0.485 0.456 -0.143
ENSG00000180891 E025 95.311637 0.0003370781 1.176481e-05 7.690581e-05 17 57885229 57885441 213 - 2.030 1.871 -0.535
ENSG00000180891 E026 71.325243 0.0144078445 1.054165e-01 1.987327e-01 17 57885442 57885645 204 - 1.866 1.765 -0.342
ENSG00000180891 E027 61.084938 0.0197970190 3.689205e-02 8.526293e-02 17 57885646 57885811 166 - 1.837 1.684 -0.517
ENSG00000180891 E028 33.546176 0.0313686089 6.458557e-02 1.343517e-01 17 57885812 57885879 68 - 1.596 1.423 -0.593
ENSG00000180891 E029 0.000000       17 57892500 57892688 189 -      
ENSG00000180891 E030 0.000000       17 57902986 57903389 404 -      
ENSG00000180891 E031 18.771971 0.1168841115 1.070174e-02 3.045855e-02 17 57955225 57955415 191 - 1.496 1.098 -1.397