ENSG00000180881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328705 ENSG00000180881 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPS2 protein_coding nonsense_mediated_decay 1.317692 0.4766052 2.284355 0.1680709 0.05426457 2.237265 0.10066313 0.03363841 0.2061370 0.01736447 0.02366432 2.308276 0.09312917 0.09130000 0.09073333 -0.0005666667 0.809667327 0.008401459 FALSE TRUE
ENST00000409799 ENSG00000180881 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPS2 protein_coding protein_coding 1.317692 0.4766052 2.284355 0.1680709 0.05426457 2.237265 0.04359745 0.00000000 0.1196498 0.00000000 0.11964984 3.696548 0.02289167 0.00000000 0.05486667 0.0548666667 1.000000000 0.008401459 FALSE TRUE
ENST00000486196 ENSG00000180881 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPS2 protein_coding processed_transcript 1.317692 0.4766052 2.284355 0.1680709 0.05426457 2.237265 0.39043424 0.02475572 0.7489786 0.02475572 0.09359225 4.448737 0.22527083 0.08493333 0.32626667 0.2413333333 0.008401459 0.008401459   FALSE
ENST00000547320 ENSG00000180881 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPS2 protein_coding processed_transcript 1.317692 0.4766052 2.284355 0.1680709 0.05426457 2.237265 0.27925352 0.10628632 0.4758479 0.06317116 0.10488122 2.062823 0.19803750 0.20436667 0.20863333 0.0042666667 1.000000000 0.008401459   FALSE
ENST00000548958 ENSG00000180881 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPS2 protein_coding processed_transcript 1.317692 0.4766052 2.284355 0.1680709 0.05426457 2.237265 0.31826747 0.28811836 0.4310524 0.13911586 0.10374667 0.565065 0.33795000 0.55296667 0.19023333 -0.3627333333 0.013077702 0.008401459   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180881 E001 2.3511236 0.013837561 0.1219887210 0.222767994 12 75275979 75276247 269 - 0.395 0.625 1.115
ENSG00000180881 E002 0.2924217 0.028910760 1.0000000000   12 75277211 75277228 18 - 0.124 0.000 -11.933
ENSG00000180881 E003 1.6492227 0.013161037 0.3627809544 0.507203245 12 75277229 75277664 436 - 0.334 0.467 0.739
ENSG00000180881 E004 4.2524782 0.005216884 0.6228694292 0.739589372 12 75277665 75279065 1401 - 0.681 0.552 -0.564
ENSG00000180881 E005 1.1178523 0.160516565 0.8891635040 0.933139217 12 75282251 75282347 97 - 0.300 0.217 -0.615
ENSG00000180881 E006 1.9993838 0.007586115 0.2767643644 0.416247329 12 75284961 75285080 120 - 0.474 0.215 -1.627
ENSG00000180881 E007 2.5746623 0.006451638 0.4551301751 0.595690702 12 75289621 75289775 155 - 0.541 0.358 -0.949
ENSG00000180881 E008 1.3222465 0.010612536 0.5671833081 0.694031482 12 75291744 75291820 77 - 0.366 0.215 -1.043
ENSG00000180881 E009 2.2112666 0.006733124 0.0268494515 0.065681066 12 75293249 75293367 119 - 0.541 0.000 -14.047
ENSG00000180881 E010 1.0351233 0.012554643 0.2037782230 0.330940250 12 75298687 75298780 94 - 0.334 0.000 -13.241
ENSG00000180881 E011 1.0436561 0.025711156 0.2084228050 0.336584593 12 75298871 75298966 96 - 0.334 0.000 -13.239
ENSG00000180881 E012 0.5933762 0.020373043 0.5159369535 0.650546820 12 75299837 75299870 34 - 0.220 0.000 -12.668
ENSG00000180881 E013 0.8857980 0.013980607 0.2735317034 0.412577712 12 75299871 75299911 41 - 0.299 0.000 -13.083
ENSG00000180881 E014 1.2587586 0.010864776 0.6810773218 0.784880380 12 75304757 75304795 39 - 0.334 0.215 -0.849
ENSG00000180881 E015 1.4027854 0.009660363 0.7714906862 0.852493473 12 75304796 75304869 74 - 0.334 0.358 0.151
ENSG00000180881 E016 0.8136755 0.014960347 0.2593109953 0.396697848 12 75304870 75304876 7 - 0.175 0.359 1.373
ENSG00000180881 E017 1.7121589 0.022068867 0.9983193721 1.000000000 12 75312848 75312915 68 - 0.396 0.359 -0.213
ENSG00000180881 E018 0.2987644 0.031751998 1.0000000000   12 75316284 75316311 28 - 0.124 0.000 -11.934
ENSG00000180881 E019 1.3318114 0.010360339 0.1191289133 0.218696609 12 75316312 75316434 123 - 0.396 0.000 -13.500
ENSG00000180881 E020 0.0000000       12 75318108 75318173 66 -      
ENSG00000180881 E021 0.7427016 0.016547611 0.3664584579 0.510797640 12 75321400 75321456 57 - 0.261 0.000 -12.897
ENSG00000180881 E022 1.1823723 0.020939088 0.1565639587 0.270526927 12 75321457 75321576 120 - 0.366 0.000 -13.376
ENSG00000180881 E023 0.0000000       12 75322936 75322973 38 -      
ENSG00000180881 E024 0.1515154 0.051933084 1.0000000000   12 75322974 75323087 114 - 0.066 0.000 -11.144
ENSG00000180881 E025 0.7363589 0.016355092 0.3682419224 0.512645426 12 75323177 75323222 46 - 0.261 0.000 -12.897
ENSG00000180881 E026 0.4375944 0.024518443 0.7763519635 0.855977922 12 75325239 75325288 50 - 0.175 0.000 -12.368
ENSG00000180881 E027 0.7687379 0.021994103 0.9735381140 0.987476108 12 75326418 75326498 81 - 0.220 0.215 -0.042
ENSG00000180881 E028 0.9139106 0.019200934 1.0000000000 1.000000000 12 75326499 75326527 29 - 0.261 0.215 -0.363
ENSG00000180881 E029 0.0000000       12 75329832 75329866 35 -      
ENSG00000180881 E030 0.0000000       12 75329867 75330025 159 -      
ENSG00000180881 E031 0.2903454 0.205826881 1.0000000000   12 75330026 75330056 31 - 0.124 0.000 -11.915
ENSG00000180881 E032 10.5070093 0.061725275 0.0003185666 0.001455164 12 75359884 75361019 1136 - 0.861 1.292 1.571
ENSG00000180881 E033 3.4545214 0.055009646 0.8997487557 0.940035548 12 75364809 75365263 455 - 0.617 0.549 -0.305
ENSG00000180881 E034 7.2447517 0.004350241 0.7366075451 0.827049663 12 75371079 75371482 404 - 0.881 0.787 -0.366
ENSG00000180881 E035 0.2987644 0.031751998 1.0000000000   12 75373498 75373918 421 - 0.124 0.000 -11.934
ENSG00000180881 E036 1.7841796 0.010755887 0.8705904551 0.920793834 12 75390322 75390381 60 - 0.423 0.358 -0.366
ENSG00000180881 E037 3.6451714 0.005452980 0.8223533058 0.888009386 12 75390838 75390901 64 - 0.634 0.552 -0.364
ENSG00000180881 E038 1.2020659 0.168651376 0.8123579323 0.880978071 12 75390902 75390908 7 - 0.333 0.216 -0.841
ENSG00000180881 E039 0.7279398 0.146492077 0.4508639554 0.591898554 12 75390909 75390910 2 - 0.261 0.000 -12.877
ENSG00000180881 E040 0.1451727 0.045629727 1.0000000000   12 75390911 75390921 11 - 0.066 0.000 -11.144
ENSG00000180881 E041 0.0000000       12 75390922 75390922 1 -      
ENSG00000180881 E042 0.0000000       12 75390923 75390928 6 -