ENSG00000180776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382466 ENSG00000180776 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC20 protein_coding protein_coding 13.97727 2.103577 23.49158 0.4654246 0.7824664 3.474999 5.1422467 0.5899812 9.079432 0.29499093 0.27193533 3.921201 0.36865417 0.30410000 0.3880333 0.08393333 7.991565e-01 1.12282e-15 FALSE TRUE
ENST00000400590 ENSG00000180776 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC20 protein_coding protein_coding 13.97727 2.103577 23.49158 0.4654246 0.7824664 3.474999 1.9203306 0.1708759 4.783210 0.05764303 0.92678824 4.727920 0.13184167 0.07973333 0.2016667 0.12193333 9.425260e-02 1.12282e-15 FALSE TRUE
ENST00000494731 ENSG00000180776 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC20 protein_coding processed_transcript 13.97727 2.103577 23.49158 0.4654246 0.7824664 3.474999 2.6026520 0.0000000 3.195274 0.00000000 0.31663675 8.324304 0.09767917 0.00000000 0.1364333 0.13643333 1.003400e-07 1.12282e-15 FALSE TRUE
ENST00000542645 ENSG00000180776 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC20 protein_coding protein_coding 13.97727 2.103577 23.49158 0.4654246 0.7824664 3.474999 2.2953687 0.3488292 4.503673 0.30957670 0.09472655 3.652933 0.16578333 0.19020000 0.1922000 0.00200000 6.638502e-01 1.12282e-15 FALSE TRUE
ENST00000626464 ENSG00000180776 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC20 protein_coding nonsense_mediated_decay 13.97727 2.103577 23.49158 0.4654246 0.7824664 3.474999 0.8580571 0.9843478 0.000000 0.44873552 0.00000000 -6.635679 0.15465417 0.42283333 0.0000000 -0.42283333 1.122820e-15 1.12282e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180776 E001 0.6330284 0.0702083513 3.113673e-02 7.416839e-02 13 21372571 21372572 2 - 0.070 0.534 3.792
ENSG00000180776 E002 0.6330284 0.0702083513 3.113673e-02 7.416839e-02 13 21372573 21372576 4 - 0.070 0.534 3.793
ENSG00000180776 E003 191.9391156 0.0150905453 4.285160e-25 4.722575e-23 13 21372577 21373193 617 - 1.895 2.620 2.423
ENSG00000180776 E004 337.2121524 0.0014571446 2.242966e-10 3.722825e-09 13 21373194 21374270 1077 - 2.234 2.532 0.994
ENSG00000180776 E005 213.4789736 0.0001861899 8.638793e-02 1.696215e-01 13 21374271 21375106 836 - 2.065 2.096 0.105
ENSG00000180776 E006 322.0036618 0.0002217686 1.094693e-10 1.919000e-09 13 21375107 21376346 1240 - 2.254 2.117 -0.459
ENSG00000180776 E007 70.3942447 0.0082979412 5.096825e-02 1.108904e-01 13 21376347 21376486 140 - 1.599 1.514 -0.290
ENSG00000180776 E008 47.6092310 0.0105789387 4.903714e-02 1.074466e-01 13 21376487 21376514 28 - 1.437 1.311 -0.436
ENSG00000180776 E009 40.0580227 0.0133589097 5.686194e-02 1.212253e-01 13 21376515 21376518 4 - 1.366 1.225 -0.492
ENSG00000180776 E010 80.7282018 0.0042028011 1.900401e-03 6.916116e-03 13 21376519 21376655 137 - 1.662 1.497 -0.563
ENSG00000180776 E011 8.1540372 0.0021228119 3.687055e-02 8.522052e-02 13 21378661 21378700 40 - 0.757 0.345 -1.956
ENSG00000180776 E012 8.2843344 0.0019466755 3.399577e-02 7.975329e-02 13 21378701 21378738 38 - 0.763 0.345 -1.983
ENSG00000180776 E013 68.6113563 0.0016046726 1.047908e-02 2.992812e-02 13 21381434 21381546 113 - 1.591 1.479 -0.385
ENSG00000180776 E014 22.2683826 0.0008414835 8.564783e-04 3.460528e-03 13 21381547 21381549 3 - 1.141 0.667 -1.816
ENSG00000180776 E015 3.6828384 0.0045582280 3.917198e-01 5.356432e-01 13 21381901 21381945 45 - 0.490 0.345 -0.786
ENSG00000180776 E016 0.0000000       13 21381946 21381994 49 -      
ENSG00000180776 E017 74.2993959 0.0031314268 6.004462e-03 1.862204e-02 13 21382920 21383009 90 - 1.626 1.496 -0.444
ENSG00000180776 E018 90.7618636 0.0003390956 5.150851e-05 2.893013e-04 13 21387508 21387634 127 - 1.715 1.513 -0.691
ENSG00000180776 E019 0.4513240 0.1741975430 1.995346e-01 3.256481e-01 13 21390195 21390254 60 - 0.070 0.343 2.781
ENSG00000180776 E020 77.0698673 0.0028790812 1.950314e-04 9.426502e-04 13 21391722 21391854 133 - 1.647 1.423 -0.766
ENSG00000180776 E021 59.7704899 0.0018759773 9.094869e-02 1.766414e-01 13 21400373 21400493 121 - 1.527 1.479 -0.161
ENSG00000180776 E022 38.4228452 0.0052952060 2.425844e-01 3.771904e-01 13 21401653 21401685 33 - 1.341 1.310 -0.107
ENSG00000180776 E023 51.1196053 0.0040160765 1.627727e-01 2.787577e-01 13 21402797 21402866 70 - 1.460 1.424 -0.124
ENSG00000180776 E024 82.7787685 0.0116987833 5.517665e-04 2.353548e-03 13 21413652 21413772 121 - 1.677 1.425 -0.862
ENSG00000180776 E025 65.2322397 0.0053522370 1.918402e-06 1.497962e-05 13 21421061 21421164 104 - 1.583 1.157 -1.479
ENSG00000180776 E026 26.5398554 0.0066249825 1.922092e-04 9.305291e-04 13 21425652 21425678 27 - 1.213 0.667 -2.074
ENSG00000180776 E027 53.4692822 0.0027188379 3.812861e-07 3.452020e-06 13 21459054 21459370 317 - 1.502 0.978 -1.856