ENSG00000180773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326402 ENSG00000180773 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A4 protein_coding protein_coding 14.17418 5.973651 19.61697 0.4453204 0.8192924 1.71374 3.6398515 1.3234724 5.596987 0.1063117 0.1567174 2.072038 0.2414417 0.2241333 0.28576667 0.06163333 2.685774e-01 8.893165e-11 FALSE TRUE
ENST00000529184 ENSG00000180773 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A4 protein_coding protein_coding 14.17418 5.973651 19.61697 0.4453204 0.8192924 1.71374 0.4131034 0.7505449 0.000000 0.2433810 0.0000000 -6.248961 0.0592500 0.1252333 0.00000000 -0.12523333 8.893165e-11 8.893165e-11 FALSE TRUE
ENST00000534116 ENSG00000180773 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A4 protein_coding protein_coding 14.17418 5.973651 19.61697 0.4453204 0.8192924 1.71374 3.5993886 0.9157652 4.494452 0.5098101 1.1107465 2.282633 0.2341833 0.1476333 0.22533333 0.07770000 7.376248e-01 8.893165e-11 FALSE TRUE
MSTRG.6166.5 ENSG00000180773 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A4 protein_coding   14.17418 5.973651 19.61697 0.4453204 0.8192924 1.71374 3.0278720 1.7910465 5.137503 0.3000274 0.9568930 1.515037 0.2253958 0.3002000 0.26670000 -0.03350000 8.833537e-01 8.893165e-11 FALSE TRUE
MSTRG.6166.6 ENSG00000180773 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC36A4 protein_coding   14.17418 5.973651 19.61697 0.4453204 0.8192924 1.71374 1.9015361 0.6607583 1.800286 0.3331182 1.0820450 1.432353 0.1445458 0.1093667 0.08803333 -0.02133333 9.686090e-01 8.893165e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180773 E001 189.0596228 0.0075385735 4.185721e-04 1.845495e-03 11 93144174 93147195 3022 - 2.296 2.110 -0.621
ENSG00000180773 E002 30.8421563 0.0022300462 1.300667e-09 1.887746e-08 11 93147196 93147409 214 - 1.582 1.044 -1.885
ENSG00000180773 E003 133.1659990 0.0003065755 5.682403e-02 1.211554e-01 11 93147410 93148147 738 - 2.119 2.044 -0.252
ENSG00000180773 E004 38.3997693 0.0020117590 1.013591e-01 1.925454e-01 11 93148148 93148314 167 - 1.536 1.626 0.307
ENSG00000180773 E005 24.8220734 0.0009525152 4.044308e-02 9.183532e-02 11 93148315 93148420 106 - 1.334 1.471 0.474
ENSG00000180773 E006 38.0289854 0.0006369193 9.221415e-03 2.683805e-02 11 93148421 93148500 80 - 1.510 1.653 0.486
ENSG00000180773 E007 69.3066452 0.0003973261 1.130820e-03 4.407127e-03 11 93148501 93148652 152 - 1.771 1.903 0.444
ENSG00000180773 E008 51.5923619 0.0017263905 5.298007e-03 1.674270e-02 11 93148653 93148726 74 - 1.643 1.780 0.464
ENSG00000180773 E009 85.2681056 0.0003167746 2.751773e-05 1.651456e-04 11 93148727 93148844 118 - 1.851 2.005 0.516
ENSG00000180773 E010 2.0807540 0.0126246449 2.629002e-01 4.007278e-01 11 93151919 93151976 58 - 0.531 0.313 -1.182
ENSG00000180773 E011 0.2998086 0.0285334430 4.647032e-01   11 93153964 93154107 144 - 0.079 0.184 1.403
ENSG00000180773 E012 41.6939488 0.0005396477 4.697235e-03 1.508829e-02 11 93154108 93154120 13 - 1.549 1.697 0.503
ENSG00000180773 E013 53.6665296 0.0005437663 9.789378e-04 3.887821e-03 11 93154121 93154156 36 - 1.653 1.806 0.519
ENSG00000180773 E014 96.8346177 0.0002878005 5.746475e-05 3.188976e-04 11 93154157 93154277 121 - 1.913 2.050 0.461
ENSG00000180773 E015 6.0475911 0.0028099983 1.960891e-01 3.213309e-01 11 93154278 93155488 1211 - 0.869 0.673 -0.787
ENSG00000180773 E016 120.9335214 0.0003095945 7.947516e-01 8.688868e-01 11 93162706 93162875 170 - 2.057 2.054 -0.009
ENSG00000180773 E017 99.6460478 0.0037268481 7.214106e-01 8.158130e-01 11 93165918 93166016 99 - 1.973 1.979 0.019
ENSG00000180773 E018 0.7384472 0.0339075019 5.421378e-01 6.729505e-01 11 93166017 93167530 1514 - 0.204 0.313 0.815
ENSG00000180773 E019 117.9157118 0.0002866923 5.843811e-01 7.083322e-01 11 93167944 93168171 228 - 2.044 2.052 0.025
ENSG00000180773 E020 3.5556446 0.0172188037 9.604200e-01 9.790666e-01 11 93170111 93170153 43 - 0.623 0.622 -0.006
ENSG00000180773 E021 3.0365809 0.0062464331 5.654048e-01 6.925072e-01 11 93170154 93170221 68 - 0.602 0.494 -0.500
ENSG00000180773 E022 73.4847175 0.0003587128 3.562352e-01 5.006245e-01 11 93180797 93180881 85 - 1.856 1.803 -0.179
ENSG00000180773 E023 75.2096997 0.0004019410 3.352525e-01 4.790294e-01 11 93181691 93181786 96 - 1.868 1.813 -0.184
ENSG00000180773 E024 46.1041101 0.0004837276 3.704010e-01 5.148302e-01 11 93182806 93182834 29 - 1.661 1.598 -0.212
ENSG00000180773 E025 62.9228622 0.0011374300 2.160469e-01 3.456440e-01 11 93182835 93182894 60 - 1.798 1.723 -0.252
ENSG00000180773 E026 70.1439080 0.0004061814 7.564649e-02 1.525386e-01 11 93184430 93184520 91 - 1.851 1.757 -0.318
ENSG00000180773 E027 0.5848434 0.0222451888 2.477562e-01 3.832910e-01 11 93185220 93185690 471 - 0.255 0.000 -10.574
ENSG00000180773 E028 72.6177016 0.0009471340 7.448537e-03 2.238176e-02 11 93185691 93185814 124 - 1.876 1.736 -0.473
ENSG00000180773 E029 0.2214452 0.0403366590 1.709530e-01   11 93197192 93197455 264 - 0.000 0.185 11.112
ENSG00000180773 E030 47.7264244 0.0067941899 4.838366e-02 1.063024e-01 11 93197778 93197991 214 - 1.699 1.549 -0.511
ENSG00000180773 E031 0.0000000       11 93236980 93237020 41 -