ENSG00000180628

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336126 ENSG00000180628 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF5 protein_coding protein_coding 21.01292 28.43241 19.02842 1.52925 0.6379234 -0.5791301 2.7176199 0.7119159 4.829525 0.1119659 0.1232378 2.7449628 0.14414583 0.02533333 0.2540000 0.22866667 6.311412e-30 6.311412e-30 FALSE TRUE
ENST00000490164 ENSG00000180628 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF5 protein_coding processed_transcript 21.01292 28.43241 19.02842 1.52925 0.6379234 -0.5791301 11.8480040 21.5325580 6.026453 1.0998095 0.5495203 -1.8354166 0.53513750 0.75763333 0.3166667 -0.44096667 3.896615e-22 6.311412e-30   FALSE
ENST00000496708 ENSG00000180628 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF5 protein_coding processed_transcript 21.01292 28.43241 19.02842 1.52925 0.6379234 -0.5791301 0.7883973 1.9491520 0.000000 0.4904430 0.0000000 -7.6140855 0.03336250 0.06773333 0.0000000 -0.06773333 1.432877e-11 6.311412e-30   FALSE
MSTRG.4364.1 ENSG00000180628 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF5 protein_coding   21.01292 28.43241 19.02842 1.52925 0.6379234 -0.5791301 4.4095983 4.1867911 5.766886 0.2100189 0.4928898 0.4610053 0.21997083 0.14730000 0.3037000 0.15640000 1.012781e-05 6.311412e-30   FALSE
MSTRG.4364.2 ENSG00000180628 HEK293_OSMI2_2hA HEK293_TMG_2hB PCGF5 protein_coding   21.01292 28.43241 19.02842 1.52925 0.6379234 -0.5791301 1.0076277 0.0000000 1.920652 0.0000000 0.2915843 7.5929443 0.05437083 0.00000000 0.1001000 0.10010000 2.400517e-23 6.311412e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180628 E001 1.075921 0.0120619507 2.293989e-01 3.617177e-01 10 91162972 91162983 12 + 0.459 0.127 -2.472
ENSG00000180628 E002 4.637936 0.0219058533 1.048109e-01 1.978154e-01 10 91162984 91163011 28 + 0.930 0.481 -1.889
ENSG00000180628 E003 14.311061 0.0027388988 6.383110e-01 7.519625e-01 10 91163012 91163081 70 + 1.303 1.034 -0.960
ENSG00000180628 E004 0.000000       10 91220151 91220176 26 +      
ENSG00000180628 E005 0.000000       10 91220177 91220280 104 +      
ENSG00000180628 E006 0.000000       10 91220281 91220327 47 +      
ENSG00000180628 E007 5.592031 0.0045909618 5.118247e-02 1.112606e-01 10 91220371 91220662 292 + 0.779 0.830 0.203
ENSG00000180628 E008 34.668697 0.0013352654 3.406961e-14 1.036017e-12 10 91220663 91220782 120 + 1.416 1.643 0.780
ENSG00000180628 E009 41.822380 0.0007136748 1.345209e-15 5.005809e-14 10 91220783 91220836 54 + 1.513 1.714 0.684
ENSG00000180628 E010 262.958373 0.0032648159 6.809317e-27 8.698616e-25 10 91222689 91222983 295 + 2.372 2.460 0.292
ENSG00000180628 E011 361.047352 0.0002303536 0.000000e+00 0.000000e+00 10 91227337 91227960 624 + 2.225 2.731 1.688
ENSG00000180628 E012 34.747333 0.0006414848 3.341811e-26 4.050518e-24 10 91240484 91240580 97 + 1.842 0.732 -3.962
ENSG00000180628 E013 33.668727 0.0005936783 3.442674e-23 3.117611e-21 10 91248505 91248560 56 + 1.822 0.784 -3.688
ENSG00000180628 E014 33.662740 0.0006327430 3.560137e-24 3.597106e-22 10 91248665 91248724 60 + 1.826 0.759 -3.801
ENSG00000180628 E015 43.292362 0.0030399722 7.184486e-27 9.147038e-25 10 91251292 91251440 149 + 1.935 0.850 -3.805
ENSG00000180628 E016 27.240445 0.0037974805 1.995525e-17 9.373821e-16 10 91261326 91261424 99 + 1.736 0.704 -3.721
ENSG00000180628 E017 36.007020 0.0041694289 1.263010e-23 1.200569e-21 10 91264431 91264520 90 + 1.859 0.732 -4.019
ENSG00000180628 E018 19.254722 0.0019742352 2.632047e-12 6.033803e-11 10 91271638 91271697 60 + 1.579 0.642 -3.447
ENSG00000180628 E019 546.563634 0.0238123929 5.394757e-26 6.448078e-24 10 91278269 91284337 6069 + 3.000 2.151 -2.829