ENSG00000180592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000444772 ENSG00000180592 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIDA1 protein_coding protein_coding 0.9573478 0.7701963 0.9587606 0.04524419 0.108683 0.3123029 0.1886143 0.0000000 0.3812507 0.00000000 0.1396787 5.2900213 0.1680625 0 0.3779333 0.3779333 0.0001605393 0.0001514606 FALSE TRUE
ENST00000449193 ENSG00000180592 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIDA1 protein_coding protein_coding 0.9573478 0.7701963 0.9587606 0.04524419 0.108683 0.3123029 0.7532107 0.7701963 0.5775099 0.04524419 0.0452223 -0.4092241 0.8076125 1 0.6220667 -0.3779333 0.0001514606 0.0001514606 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180592 E001 64.0252582 0.0006467201 7.305526e-10 1.111476e-08 10 21513475 21515015 1541 - 1.668 1.887 0.740
ENSG00000180592 E002 70.6101502 0.0004708977 9.360032e-10 1.395365e-08 10 21515016 21516916 1901 - 1.949 1.764 -0.622
ENSG00000180592 E003 2.9400311 0.0605516946 2.690811e-01 4.075518e-01 10 21516917 21517153 237 - 0.691 0.491 -0.899
ENSG00000180592 E004 8.0174798 0.0024105632 9.272912e-01 9.582305e-01 10 21517154 21518565 1412 - 0.946 0.956 0.036
ENSG00000180592 E005 2.3219033 0.0072438620 7.445183e-01 8.328380e-01 10 21518566 21519507 942 - 0.543 0.489 -0.258
ENSG00000180592 E006 0.6060617 0.8148645587 2.549296e-01 3.917114e-01 10 21519508 21519658 151 - 0.388 0.000 -11.041
ENSG00000180592 E007 0.7813216 0.0249865412 8.100201e-01 8.794150e-01 10 21521389 21521480 92 - 0.234 0.277 0.322
ENSG00000180592 E008 1.4046833 0.1172635757 6.431163e-02 1.338847e-01 10 21523683 21523871 189 - 0.132 0.520 2.698
ENSG00000180592 E009 0.0000000       10 21523872 21523895 24 -      
ENSG00000180592 E010 0.8887149 0.5600100667 5.337393e-01 6.658894e-01 10 21525547 21525682 136 - 0.132 0.374 1.942
ENSG00000180592 E011 0.1817044 0.0403669543 5.644215e-01   10 21526291 21526368 78 - 0.000 0.113 10.821