ENSG00000180488

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370791 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding protein_coding 10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 0.7152641 0.57631253 0.09861522 0.16441863 0.09861522 -2.4324436 0.1121542 0.180366667 0.006633333 -0.17373333 6.655510e-03 6.202699e-22 FALSE TRUE
ENST00000443751 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding protein_coding 10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 1.3848310 0.06273348 3.13123421 0.06273348 0.28498670 5.4325682 0.1129417 0.019633333 0.231966667 0.21233333 9.660128e-03 6.202699e-22 FALSE TRUE
ENST00000642959 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding protein_coding 10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 0.4868119 0.00000000 0.72382743 0.00000000 0.14191074 6.1973689 0.0294750 0.000000000 0.052666667 0.05266667 2.199588e-04 6.202699e-22 FALSE TRUE
ENST00000643143 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding nonsense_mediated_decay 10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 0.7848557 0.00000000 1.57322634 0.00000000 0.23084211 7.3067237 0.0471625 0.000000000 0.114500000 0.11450000 1.209264e-08 6.202699e-22 TRUE TRUE
MSTRG.1452.5 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding   10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 1.6668750 0.00000000 2.37882404 0.00000000 0.45016046 7.9001568 0.1034875 0.000000000 0.172800000 0.17280000 4.454902e-09 6.202699e-22 FALSE TRUE
MSTRG.1452.6 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding   10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 1.5515520 0.03684945 2.15594227 0.03684945 0.29021934 5.5308189 0.0945875 0.009033333 0.158166667 0.14913333 1.489738e-05 6.202699e-22 FALSE TRUE
MSTRG.1452.9 ENSG00000180488 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA1 protein_coding   10.01963 3.257216 13.64283 0.456207 0.6150391 2.063066 2.8637239 2.32950874 2.64124235 0.31576773 0.22085073 0.1804629 0.4438542 0.716400000 0.193066667 -0.52333333 6.202699e-22 6.202699e-22 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180488 E001 0.1817044 0.0416417799 3.446721e-02   1 77779624 77779629 6 + 0.000 0.299 12.702
ENSG00000180488 E002 0.1817044 0.0416417799 3.446721e-02   1 77779630 77779632 3 + 0.000 0.299 14.914
ENSG00000180488 E003 0.3268771 0.0288164594 1.191336e-01   1 77779633 77779633 1 + 0.044 0.299 3.215
ENSG00000180488 E004 0.6537541 0.5287271143 1.159737e-01 2.142037e-01 1 77779634 77779635 2 + 0.084 0.477 3.235
ENSG00000180488 E005 2.6562716 0.2779394112 3.296717e-01 4.732036e-01 1 77779636 77779648 13 + 0.379 0.699 1.525
ENSG00000180488 E006 6.3141389 0.0321185537 5.505132e-03 1.730086e-02 1 77779649 77779659 11 + 0.613 1.077 1.820
ENSG00000180488 E007 31.2212944 0.0006959960 1.174934e-02 3.293499e-02 1 77779660 77779736 77 + 1.287 1.528 0.832
ENSG00000180488 E008 0.0000000       1 77779763 77779774 12 +      
ENSG00000180488 E009 0.8189741 0.0235736367 5.020614e-01 6.381630e-01 1 77779775 77779903 129 + 0.155 0.300 1.217
ENSG00000180488 E010 0.7447779 0.0954684469 1.000000e+00 1.000000e+00 1 77779904 77779967 64 + 0.186 0.000 -13.536
ENSG00000180488 E011 1.9907347 0.1885924701 7.286143e-02 1.481002e-01 1 77779968 77780192 225 + 0.268 0.705 2.252
ENSG00000180488 E012 19.9403885 0.0009123052 1.412521e-01 2.497530e-01 1 77783238 77783242 5 + 1.113 1.297 0.655
ENSG00000180488 E013 29.2994060 0.0006444734 4.483619e-02 9.989981e-02 1 77783243 77783267 25 + 1.268 1.473 0.715
ENSG00000180488 E014 44.6023316 0.0004930251 1.506139e-03 5.656218e-03 1 77783268 77783351 84 + 1.434 1.686 0.862
ENSG00000180488 E015 18.0382972 0.0125323330 1.310193e-30 2.302525e-28 1 77788008 77788194 187 + 0.731 1.834 3.940
ENSG00000180488 E016 49.2403336 0.0004606044 9.872469e-07 8.199876e-06 1 77801331 77801508 178 + 1.546 1.076 -1.648
ENSG00000180488 E017 34.7041320 0.0006351076 1.576433e-03 5.882422e-03 1 77803270 77803388 119 + 1.393 1.076 -1.121
ENSG00000180488 E018 21.7686597 0.0008714852 3.397109e-02 7.969933e-02 1 77803389 77803406 18 + 1.197 0.951 -0.894
ENSG00000180488 E019 40.6192289 0.0005382366 7.826478e-04 3.197410e-03 1 77806975 77807101 127 + 1.456 1.143 -1.096
ENSG00000180488 E020 36.8940426 0.0005485155 2.309653e-04 1.095700e-03 1 77813734 77813867 134 + 1.418 1.038 -1.346
ENSG00000180488 E021 30.2966365 0.0009012431 2.544060e-02 6.279013e-02 1 77815108 77815231 124 + 1.328 1.111 -0.770
ENSG00000180488 E022 35.0772038 0.0005587706 3.202528e-02 7.590970e-02 1 77843307 77843407 101 + 1.387 1.201 -0.654
ENSG00000180488 E023 39.9782288 0.0005191308 2.149557e-02 5.463599e-02 1 77858938 77859056 119 + 1.441 1.252 -0.658
ENSG00000180488 E024 1.4833268 0.0089274639 3.099050e-01 4.522495e-01 1 77859057 77859313 257 + 0.316 0.000 -14.936
ENSG00000180488 E025 24.0033807 0.0010617030 3.015392e-02 7.227076e-02 1 77859314 77859386 73 + 1.236 0.997 -0.864
ENSG00000180488 E026 3.3290303 0.0047987620 6.322231e-01 7.471105e-01 1 77859387 77860039 653 + 0.481 0.599 0.551
ENSG00000180488 E027 32.5390105 0.0006574510 1.043903e-02 2.983635e-02 1 77860040 77860126 87 + 1.360 1.111 -0.880
ENSG00000180488 E028 6.4775907 0.0226107998 2.028855e-01 3.298268e-01 1 77860127 77861223 1097 + 0.731 0.475 -1.141
ENSG00000180488 E029 36.4683760 0.0009115286 4.041183e-02 9.177646e-02 1 77861224 77861322 99 + 1.400 1.227 -0.606
ENSG00000180488 E030 1.7673295 0.0086715105 2.264513e-01 3.581640e-01 1 77861323 77862215 893 + 0.358 0.000 -15.155
ENSG00000180488 E031 44.2985242 0.0004848542 1.842975e-01 3.066209e-01 1 77863894 77864028 135 + 1.476 1.394 -0.283
ENSG00000180488 E032 31.3212242 0.0006687707 3.840356e-01 5.282383e-01 1 77866338 77866391 54 + 1.330 1.275 -0.193
ENSG00000180488 E033 3.0956981 0.1083073064 1.059756e-03 4.165475e-03 1 77868248 77868636 389 + 0.315 0.997 3.065
ENSG00000180488 E034 8.5903720 0.0021061666 4.748344e-02 1.047022e-01 1 77873001 77873003 3 + 0.844 0.475 -1.593
ENSG00000180488 E035 36.2966018 0.0005923529 1.988796e-02 5.125027e-02 1 77873004 77873120 117 + 1.404 1.201 -0.712
ENSG00000180488 E036 145.9945935 0.0415612651 2.641356e-02 6.477317e-02 1 77874846 77876163 1318 + 1.992 1.807 -0.623
ENSG00000180488 E037 84.2292204 0.0003259555 1.055402e-01 1.989243e-01 1 77876164 77877052 889 + 1.746 1.678 -0.231
ENSG00000180488 E038 184.5875062 0.0002348255 7.550419e-01 8.405041e-01 1 77877053 77878755 1703 + 2.071 2.113 0.144
ENSG00000180488 E039 44.8136551 0.0227666000 3.319901e-15 1.173187e-13 1 77878756 77879540 785 + 1.296 2.035 2.514