ENSG00000180448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313093 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding protein_coding 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.27377603 0.5736631 0.06452059 0.14352280 0.06452059 -2.9694248 0.19106250 0.2947667 0.07800000 -0.21676667 0.22559215 0.04842222 FALSE TRUE
ENST00000539243 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding protein_coding 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.01705246 0.0000000 0.05800027 0.00000000 0.05800027 2.7655404 0.01982917 0.0000000 0.11963333 0.11963333 0.66765553 0.04842222 FALSE TRUE
ENST00000543365 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding protein_coding 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.03948903 0.0000000 0.01277528 0.00000000 0.01277528 1.1874690 0.06418333 0.0000000 0.01963333 0.01963333 0.61739299 0.04842222 FALSE TRUE
ENST00000586033 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding retained_intron 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.01663934 0.0000000 0.05669710 0.00000000 0.05669710 2.7376241 0.01796250 0.0000000 0.08720000 0.08720000 0.59769918 0.04842222 FALSE FALSE
ENST00000586378 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding retained_intron 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.21496850 0.0000000 0.06758335 0.00000000 0.06758335 2.9557470 0.14969167 0.0000000 0.10393333 0.10393333 0.62194241 0.04842222 FALSE TRUE
ENST00000586866 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding protein_coding 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.02708124 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05985000 0.0000000 0.00000000 0.00000000   0.04842222 FALSE TRUE
ENST00000587186 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding protein_coding 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.02262147 0.0000000 0.04847283 0.00000000 0.04847283 2.5477664 0.02304167 0.0000000 0.05860000 0.05860000 0.50997214 0.04842222 FALSE FALSE
ENST00000590512 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding processed_transcript 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.03142445 0.0000000 0.09141903 0.00000000 0.04733943 3.3422565 0.03578750 0.0000000 0.14350000 0.14350000 0.04842222 0.04842222   FALSE
ENST00000590577 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding protein_coding 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.15298839 0.2221259 0.20219211 0.04117161 0.04330653 -0.1295366 0.17054583 0.1286667 0.30363333 0.17496667 0.12254656 0.04842222 FALSE TRUE
ENST00000591169 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding nonsense_mediated_decay 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.69262568 0.3220335 0.02600327 0.32203345 0.02600327 -3.2051286 0.09518333 0.1415000 0.03143333 -0.11006667 0.96639704 0.04842222 FALSE TRUE
ENST00000592297 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding retained_intron 1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.07711726 0.4018481 0.00000000 0.40184806 0.00000000 -5.3640403 0.04700417 0.1960333 0.00000000 -0.19603333 0.94784511 0.04842222 FALSE TRUE
MSTRG.16036.12 ENSG00000180448 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP45 protein_coding   1.670134 1.87656 0.6540231 0.2937082 0.09882171 -1.506453 0.07434358 0.2824438 0.02635924 0.15392826 0.02635924 -3.0077656 0.09237917 0.1819333 0.05436667 -0.12756667 0.71588111 0.04842222 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180448 E001 0.1515154 0.0430661637 0.108939950   19 1065923 1066163 241 + 0.218 0.000 -11.729
ENSG00000180448 E002 0.1451727 0.0420339381 0.109566010   19 1066509 1066641 133 + 0.218 0.000 -14.288
ENSG00000180448 E003 0.8083770 0.0326090048 0.325572596 0.469000704 19 1067167 1067316 150 + 0.362 0.172 -1.421
ENSG00000180448 E004 0.6632043 0.0186679587 0.814055374 0.882166505 19 1067317 1067318 2 + 0.218 0.172 -0.420
ENSG00000180448 E005 0.8083770 0.0326090048 0.325572596 0.469000704 19 1067319 1067326 8 + 0.362 0.172 -1.421
ENSG00000180448 E006 2.0564352 0.0086493692 0.697266454 0.797434579 19 1067327 1067495 169 + 0.471 0.391 -0.419
ENSG00000180448 E007 0.0000000       19 1067498 1067674 177 +      
ENSG00000180448 E008 0.1482932 0.0423404661 1.000000000   19 1068333 1068413 81 + 0.000 0.065 10.708
ENSG00000180448 E009 5.1258777 0.1721531389 0.461623594 0.601544941 19 1068414 1068744 331 + 0.556 0.702 0.636
ENSG00000180448 E010 0.0000000       19 1071221 1071358 138 +      
ENSG00000180448 E011 0.0000000       19 1071513 1071766 254 +      
ENSG00000180448 E012 3.9540920 0.1573824068 0.282082366 0.422037528 19 1073149 1073223 75 + 0.362 0.625 1.304
ENSG00000180448 E013 3.9990442 0.0193085252 0.423355223 0.566416030 19 1073224 1073292 69 + 0.471 0.613 0.667
ENSG00000180448 E014 4.7104360 0.0390140654 0.832504081 0.895041136 19 1073506 1073582 77 + 0.691 0.646 -0.192
ENSG00000180448 E015 2.0691337 0.0611877903 0.718436983 0.813536322 19 1073583 1073590 8 + 0.471 0.392 -0.420
ENSG00000180448 E016 0.0000000       19 1073591 1073673 83 +      
ENSG00000180448 E017 3.9888153 0.0058688857 0.861139101 0.914430514 19 1073674 1073746 73 + 0.629 0.594 -0.156
ENSG00000180448 E018 3.4330930 0.0048699862 0.607149490 0.727199817 19 1073948 1074014 67 + 0.629 0.536 -0.419
ENSG00000180448 E019 4.3499337 0.0144481939 0.908303089 0.945749262 19 1074104 1074241 138 + 0.629 0.643 0.061
ENSG00000180448 E020 3.1988868 0.0562394903 0.673076722 0.778867946 19 1074343 1074407 65 + 0.471 0.554 0.399
ENSG00000180448 E021 2.6278380 0.0798326566 0.627251012 0.743064173 19 1074614 1074724 111 + 0.557 0.466 -0.441
ENSG00000180448 E022 2.9443054 0.0056585008 0.877844955 0.925556482 19 1074799 1074879 81 + 0.471 0.494 0.114
ENSG00000180448 E023 1.8788860 0.0229039364 0.004976041 0.015863093 19 1077487 1077856 370 + 0.745 0.258 -2.492
ENSG00000180448 E024 5.8228458 0.0030787994 0.497574638 0.634115576 19 1077857 1078045 189 + 0.629 0.732 0.431
ENSG00000180448 E025 5.2316491 0.0034447966 0.677161595 0.781947048 19 1079703 1079757 55 + 0.629 0.691 0.260
ENSG00000180448 E026 6.0796677 0.0030249469 0.434616653 0.576935837 19 1079758 1079840 83 + 0.837 0.718 -0.473
ENSG00000180448 E027 7.8342059 0.0037425796 0.168405585 0.286103136 19 1079928 1080118 191 + 0.976 0.793 -0.703
ENSG00000180448 E028 5.8186826 0.0032200970 0.335551581 0.479330123 19 1080255 1080379 125 + 0.837 0.691 -0.588
ENSG00000180448 E029 0.0000000       19 1080380 1080463 84 +      
ENSG00000180448 E030 4.5327709 0.0057868934 0.803847763 0.875194951 19 1080464 1080547 84 + 0.691 0.644 -0.199
ENSG00000180448 E031 4.3585406 0.0042371436 0.974436565 0.988032991 19 1080682 1080786 105 + 0.629 0.628 -0.004
ENSG00000180448 E032 6.8233222 0.0027006730 0.713435541 0.809936917 19 1080892 1081064 173 + 0.745 0.792 0.189
ENSG00000180448 E033 0.0000000       19 1081415 1081549 135 +      
ENSG00000180448 E034 7.5952667 0.0196358189 0.791585865 0.866696146 19 1081550 1081738 189 + 0.793 0.826 0.130
ENSG00000180448 E035 6.8610884 0.0028987944 0.667278110 0.774570408 19 1081824 1081961 138 + 0.837 0.769 -0.266
ENSG00000180448 E036 0.2966881 0.0290785164 0.020983820   19 1082521 1082657 137 + 0.362 0.000 -15.200
ENSG00000180448 E037 0.1472490 0.0461634512 0.108795345   19 1082784 1082839 56 + 0.218 0.000 -14.278
ENSG00000180448 E038 5.0605433 0.0046228024 0.171967225 0.290761606 19 1082840 1082840 1 + 0.837 0.629 -0.851
ENSG00000180448 E039 6.9749263 0.0041120717 0.467261453 0.606775612 19 1082841 1082938 98 + 0.876 0.769 -0.418
ENSG00000180448 E040 5.1187562 0.0032479140 0.676888133 0.781717037 19 1082939 1083066 128 + 0.629 0.690 0.259
ENSG00000180448 E041 1.4026941 0.0100186398 0.569204532 0.695793592 19 1083067 1083142 76 + 0.218 0.330 0.803
ENSG00000180448 E042 9.8778045 0.0025626600 0.885666201 0.930866389 19 1083143 1083275 133 + 0.946 0.920 -0.097
ENSG00000180448 E043 9.4298176 0.0282817043 0.548274422 0.678138744 19 1083276 1083353 78 + 0.976 0.887 -0.335
ENSG00000180448 E044 13.6714700 0.0169789456 0.384079263 0.528268627 19 1084238 1084346 109 + 0.946 1.056 0.410
ENSG00000180448 E045 38.4383969 0.0006680465 0.002178802 0.007776183 19 1085660 1086628 969 + 1.284 1.499 0.744