ENSG00000180376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341455 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding nonsense_mediated_decay 13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 0.32694842 0.33573968 0.3102666 0.16882134 0.13051824 -0.1104126 0.03467500 0.08393333 0.01633333 -0.067600000 4.219007e-01 1.324933e-08 FALSE  
ENST00000460838 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding processed_transcript 13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 0.63827982 0.07232481 1.2951251 0.07232481 0.17300306 3.9867171 0.03195000 0.01476667 0.06866667 0.053900000 8.472068e-02 1.324933e-08 FALSE  
ENST00000468108 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding retained_intron 13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 2.08967413 0.53078822 2.4809506 0.27301412 0.27056992 2.2035608 0.15798750 0.12913333 0.13360000 0.004466667 8.781999e-01 1.324933e-08 FALSE  
ENST00000484441 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding retained_intron 13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 0.42146531 0.30411239 0.1389004 0.19026937 0.13890037 -1.0769335 0.04261250 0.07046667 0.00690000 -0.063566667 3.112132e-01 1.324933e-08    
ENST00000487739 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding retained_intron 13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 0.86980642 0.29619968 1.0436824 0.14647319 0.31190258 1.7828954 0.06756667 0.08390000 0.05436667 -0.029533333 8.652346e-01 1.324933e-08    
MSTRG.23130.16 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding   13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 1.78799504 0.46878809 2.8921739 0.23891328 0.18615622 2.5996748 0.13038750 0.13983333 0.15470000 0.014866667 8.421949e-01 1.324933e-08 FALSE  
MSTRG.23130.17 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding   13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 0.59795064 0.22017998 0.7284394 0.02534004 0.00942703 1.6817172 0.05078750 0.05896667 0.03926667 -0.019700000 4.585564e-01 1.324933e-08 TRUE  
MSTRG.23130.23 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding   13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 0.04157768 0.21969078 0.0000000 0.04448783 0.00000000 -4.5216210 0.01136667 0.06123333 0.00000000 -0.061233333 1.324933e-08 1.324933e-08 FALSE  
MSTRG.23130.6 ENSG00000180376 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC66 protein_coding   13.84521 3.865986 18.71329 0.5172631 1.129289 2.272199 2.61062757 0.61028304 4.9549525 0.39421020 0.77083957 3.0007813 0.16256667 0.13923333 0.26160000 0.122366667 5.789289e-01 1.324933e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180376 E001 0.1451727 0.0423761483 1.000000e+00   3 56557161 56557162 2 + 0.067 0.000 -8.757
ENSG00000180376 E002 0.1451727 0.0423761483 1.000000e+00   3 56557163 56557174 12 + 0.067 0.000 -10.792
ENSG00000180376 E003 0.4375944 0.0242099523 5.820169e-01 7.064503e-01 3 56557175 56557182 8 + 0.176 0.000 -12.322
ENSG00000180376 E004 0.4375944 0.0242099523 5.820169e-01 7.064503e-01 3 56557183 56557183 1 + 0.176 0.000 -12.322
ENSG00000180376 E005 1.3254687 0.0099713270 8.343055e-02 1.649344e-01 3 56557184 56557187 4 + 0.397 0.000 -13.762
ENSG00000180376 E006 3.5473445 0.0044417710 1.715680e-03 6.331431e-03 3 56557188 56557190 3 + 0.698 0.000 -14.951
ENSG00000180376 E007 5.3512057 0.0031214582 1.555756e-03 5.816033e-03 3 56557191 56557202 12 + 0.834 0.214 -3.191
ENSG00000180376 E008 6.6830171 0.0024655730 2.169693e-04 1.036545e-03 3 56557203 56557209 7 + 0.920 0.214 -3.521
ENSG00000180376 E009 8.0699965 0.0030335931 3.292713e-04 1.497994e-03 3 56557210 56557210 1 + 0.984 0.357 -2.762
ENSG00000180376 E010 9.2502925 0.0023438363 6.259967e-05 3.441774e-04 3 56557211 56557218 8 + 1.040 0.357 -2.968
ENSG00000180376 E011 13.5985264 0.0018042492 9.802002e-06 6.530773e-05 3 56557219 56557227 9 + 1.189 0.550 -2.504
ENSG00000180376 E012 19.5634917 0.0059221377 2.654399e-06 2.010989e-05 3 56557228 56557234 7 + 1.334 0.737 -2.207
ENSG00000180376 E013 26.1118394 0.0008309722 7.285642e-06 4.994366e-05 3 56557235 56557253 19 + 1.438 0.997 -1.567
ENSG00000180376 E014 1.3370082 0.0211957949 4.563911e-01 5.968242e-01 3 56557254 56557263 10 + 0.367 0.214 -1.064
ENSG00000180376 E015 0.0000000       3 56557707 56557957 251 +      
ENSG00000180376 E016 0.2214452 0.0373527545 1.120753e-01   3 56558845 56558845 1 + 0.000 0.215 13.079
ENSG00000180376 E017 27.8616760 0.0007233927 1.199318e-05 7.824743e-05 3 56558846 56558854 9 + 1.461 1.049 -1.454
ENSG00000180376 E018 36.8442136 0.0213206499 1.846988e-02 4.816396e-02 3 56558855 56558910 56 + 1.555 1.310 -0.845
ENSG00000180376 E019 28.3324740 0.0007225088 7.029423e-03 2.130180e-02 3 56559569 56559594 26 + 1.443 1.212 -0.807
ENSG00000180376 E020 9.9966151 0.0037252706 1.666640e-01 2.838495e-01 3 56560862 56561012 151 + 1.013 0.828 -0.699
ENSG00000180376 E021 4.5521996 0.0106237369 9.345880e-01 9.628030e-01 3 56561013 56561222 210 + 0.698 0.683 -0.064
ENSG00000180376 E022 3.4259282 0.0566499105 9.078346e-01 9.455136e-01 3 56561257 56561378 122 + 0.601 0.618 0.075
ENSG00000180376 E023 1.9552749 0.0072984094 8.310243e-01 8.940602e-01 3 56563516 56563651 136 + 0.425 0.464 0.200
ENSG00000180376 E024 1.5166363 0.0090961466 9.610241e-01 9.794613e-01 3 56563652 56563683 32 + 0.367 0.357 -0.062
ENSG00000180376 E025 53.7407819 0.0004853540 1.269852e-03 4.876643e-03 3 56563684 56563825 142 + 1.709 1.508 -0.685
ENSG00000180376 E026 35.4540169 0.0082934876 8.084768e-03 2.399547e-02 3 56563826 56563905 80 + 1.539 1.304 -0.811
ENSG00000180376 E027 64.5789778 0.0034423589 4.425672e-03 1.433372e-02 3 56563906 56564125 220 + 1.786 1.607 -0.604
ENSG00000180376 E028 0.5244761 0.2598885253 5.965310e-01 7.184695e-01 3 56564126 56564156 31 + 0.125 0.217 0.959
ENSG00000180376 E029 1.1888288 0.0123048958 1.112602e-01 2.074005e-01 3 56565134 56565204 71 + 0.367 0.000 -13.615
ENSG00000180376 E030 0.1515154 0.0423657814 1.000000e+00   3 56565205 56565205 1 + 0.067 0.000 -10.792
ENSG00000180376 E031 33.9092252 0.0018359535 6.956555e-02 1.426421e-01 3 56566594 56566660 67 + 1.508 1.367 -0.487
ENSG00000180376 E032 40.1402979 0.0032668439 1.394587e-01 2.472887e-01 3 56566661 56566738 78 + 1.573 1.463 -0.378
ENSG00000180376 E033 24.4716834 0.0035425166 1.821458e-01 3.038923e-01 3 56566739 56566740 2 + 1.367 1.245 -0.428
ENSG00000180376 E034 23.0375537 0.0008549410 9.147440e-03 2.665050e-02 3 56566741 56566759 19 + 1.364 1.117 -0.869
ENSG00000180376 E035 1.2554346 0.0113171922 6.936236e-02 1.423055e-01 3 56566783 56566949 167 + 0.221 0.550 1.937
ENSG00000180376 E036 27.3493620 0.0018777435 1.539572e-01 2.670554e-01 3 56566950 56566950 1 + 1.411 1.290 -0.423
ENSG00000180376 E037 50.8093659 0.0005022316 6.235972e-01 7.401428e-01 3 56566951 56567053 103 + 1.652 1.621 -0.106
ENSG00000180376 E038 13.2083887 0.0080938193 3.113427e-01 4.537917e-01 3 56569313 56569637 325 + 1.066 1.175 0.394
ENSG00000180376 E039 13.2526710 0.0170818664 1.355458e-02 3.720465e-02 3 56569638 56570746 1109 + 1.013 1.287 0.980
ENSG00000180376 E040 0.9244060 0.0136968632 8.182135e-01 8.851106e-01 3 56571167 56571180 14 + 0.263 0.214 -0.384
ENSG00000180376 E041 46.0436486 0.0006312587 9.961632e-01 1.000000e+00 3 56571181 56571302 122 + 1.603 1.601 -0.007
ENSG00000180376 E042 0.5149111 0.0198725068 8.627100e-02 1.694302e-01 3 56571303 56571379 77 + 0.067 0.357 2.939
ENSG00000180376 E043 10.8007256 0.0017489137 4.674832e-01 6.069928e-01 3 56572337 56572428 92 + 1.027 0.937 -0.335
ENSG00000180376 E044 1.6639819 0.0110464019 3.266456e-03 1.105096e-02 3 56572429 56572910 482 + 0.176 0.684 2.942
ENSG00000180376 E045 45.5397245 0.0029743359 7.993969e-01 8.720330e-01 3 56592970 56593101 132 + 1.594 1.608 0.049
ENSG00000180376 E046 47.0185077 0.0005877161 6.205160e-01 7.376734e-01 3 56593491 56593619 129 + 1.619 1.587 -0.109
ENSG00000180376 E047 44.1249970 0.0005271073 5.789862e-01 7.039759e-01 3 56593620 56593711 92 + 1.594 1.557 -0.126
ENSG00000180376 E048 32.8377317 0.0006148347 1.616617e-01 2.772767e-01 3 56593712 56593741 30 + 1.486 1.379 -0.367
ENSG00000180376 E049 51.6034427 0.0004417191 5.136912e-02 1.115857e-01 3 56593944 56594028 85 + 1.677 1.557 -0.409
ENSG00000180376 E050 3.9535008 0.0041347377 2.249769e-01 3.563904e-01 3 56598204 56598300 97 + 0.683 0.464 -1.000
ENSG00000180376 E051 35.0393337 0.0006843140 5.751050e-03 1.795812e-02 3 56613589 56613610 22 + 1.530 1.317 -0.736
ENSG00000180376 E052 67.8776192 0.0003460582 6.609306e-01 7.695273e-01 3 56613611 56613750 140 + 1.776 1.752 -0.082
ENSG00000180376 E053 56.7909531 0.0004501130 5.465778e-02 1.174019e-01 3 56615128 56615272 145 + 1.666 1.766 0.338
ENSG00000180376 E054 8.0347951 0.0025394744 3.396272e-01 4.835517e-01 3 56615273 56615417 145 + 0.920 0.785 -0.521
ENSG00000180376 E055 4.0181320 0.0040712199 8.618701e-01 9.149419e-01 3 56615869 56615903 35 + 0.652 0.622 -0.132
ENSG00000180376 E056 7.6478973 0.0024984511 1.658894e-01 2.828507e-01 3 56615904 56615921 18 + 0.823 0.997 0.659
ENSG00000180376 E057 52.6317838 0.0005452228 8.526676e-01 9.086883e-01 3 56615922 56616053 132 + 1.657 1.665 0.028
ENSG00000180376 E058 13.5909690 0.0023222903 3.812046e-01 5.255051e-01 3 56616054 56617100 1047 + 1.124 1.024 -0.364
ENSG00000180376 E059 1.4402475 0.1106614647 1.503917e-01 2.622104e-01 3 56617101 56617111 11 + 0.263 0.549 1.611
ENSG00000180376 E060 103.2621370 0.0002837076 3.933108e-02 8.978702e-02 3 56617112 56617400 289 + 1.928 2.007 0.265
ENSG00000180376 E061 65.1633494 0.0003633967 8.192990e-04 3.328339e-03 3 56617401 56617529 129 + 1.708 1.867 0.538
ENSG00000180376 E062 52.1700943 0.0005510295 7.179107e-04 2.963068e-03 3 56617530 56617605 76 + 1.610 1.789 0.607
ENSG00000180376 E063 25.7035426 0.0472206935 9.091817e-01 9.463117e-01 3 56617606 56618171 566 + 1.361 1.372 0.039
ENSG00000180376 E064 43.0458913 0.0005406345 1.872943e-02 4.874149e-02 3 56618172 56618212 41 + 1.539 1.677 0.470
ENSG00000180376 E065 14.2432654 0.0015146149 2.634695e-03 9.174095e-03 3 56618213 56619270 1058 + 1.034 1.317 1.010
ENSG00000180376 E066 113.7896651 0.0004481013 4.392551e-10 6.949688e-09 3 56619271 56619527 257 + 1.929 2.151 0.746
ENSG00000180376 E067 79.2981354 0.0028755278 3.330282e-09 4.480909e-08 3 56619777 56619901 125 + 1.751 2.033 0.951
ENSG00000180376 E068 54.9184030 0.0030823714 5.875159e-08 6.237565e-07 3 56621532 56625857 4326 + 1.588 1.889 1.017
ENSG00000180376 E069 0.4449813 0.0227695354 5.896955e-01 7.127248e-01 3 56626516 56626610 95 + 0.125 0.214 0.936