ENSG00000180304

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326005 ENSG00000180304 HEK293_OSMI2_2hA HEK293_TMG_2hB OAZ2 protein_coding protein_coding 78.95982 123.738 54.20981 1.652011 0.918781 -1.190513 66.942060 109.361102 43.385282 0.9137249 1.173904 -1.3336215 0.83317083 0.88403333 0.8001667 -0.08386667 0.00088937 0.00088937    
ENST00000559753 ENSG00000180304 HEK293_OSMI2_2hA HEK293_TMG_2hB OAZ2 protein_coding protein_coding 78.95982 123.738 54.20981 1.652011 0.918781 -1.190513 3.846679 3.706535 2.387382 0.5647125 1.229658 -0.6324984 0.05530417 0.02993333 0.0434000 0.01346667 0.97209037 0.00088937    
MSTRG.11023.5 ENSG00000180304 HEK293_OSMI2_2hA HEK293_TMG_2hB OAZ2 protein_coding   78.95982 123.738 54.20981 1.652011 0.918781 -1.190513 5.869699 7.114159 6.283845 1.0334671 1.317680 -0.1787781 0.08027500 0.05730000 0.1167667 0.05946667 0.15197553 0.00088937    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180304 E001 3.2397866 0.0695596330 6.358802e-01 7.500554e-01 15 64687573 64687575 3 - 0.497 0.598 0.472
ENSG00000180304 E002 7.2265151 0.0032726908 6.096611e-01 7.291140e-01 15 64687576 64687603 28 - 0.900 0.842 -0.223
ENSG00000180304 E003 248.6225367 0.0055738408 4.075730e-02 9.242806e-02 15 64687604 64687725 122 - 2.246 2.351 0.350
ENSG00000180304 E004 1385.7224388 0.0008544071 3.664383e-07 3.330805e-06 15 64687726 64688175 450 - 2.999 3.091 0.304
ENSG00000180304 E005 1120.8183810 0.0007269087 3.724497e-01 5.169155e-01 15 64688176 64688484 309 - 2.960 2.983 0.074
ENSG00000180304 E006 1510.9081328 0.0001019682 2.600083e-01 3.974839e-01 15 64688485 64688834 350 - 3.111 3.107 -0.011
ENSG00000180304 E007 798.0348846 0.0003203784 6.232384e-01 7.398698e-01 15 64689084 64689169 86 - 2.819 2.835 0.054
ENSG00000180304 E008 5.4709951 0.0060511348 2.340809e-01 3.672479e-01 15 64690167 64690373 207 - 0.870 0.713 -0.623
ENSG00000180304 E009 646.9472106 0.0008789378 8.402511e-01 9.002648e-01 15 64690374 64690419 46 - 2.731 2.743 0.040
ENSG00000180304 E010 577.6923753 0.0010176708 9.153911e-01 9.504685e-01 15 64690420 64690444 25 - 2.683 2.693 0.033
ENSG00000180304 E011 476.4374639 0.0018438033 6.112362e-01 7.303769e-01 15 64690445 64690460 16 - 2.612 2.606 -0.021
ENSG00000180304 E012 695.7635294 0.0014539204 5.306471e-01 6.632196e-01 15 64690461 64690549 89 - 2.777 2.770 -0.023
ENSG00000180304 E013 1.9801612 0.0082378516 5.083310e-01 6.437654e-01 15 64690723 64690907 185 - 0.316 0.445 0.743
ENSG00000180304 E014 1.0234039 0.1477285211 1.499964e-01 2.616656e-01 15 64690908 64691009 102 - 0.001 0.339 9.277
ENSG00000180304 E015 2.6453677 0.0093177570 4.678184e-01 6.072977e-01 15 64691010 64691433 424 - 0.415 0.553 0.684
ENSG00000180304 E016 655.0811074 0.0001831086 1.553833e-03 5.810219e-03 15 64691434 64691588 155 - 2.779 2.737 -0.142
ENSG00000180304 E017 239.2697483 0.0009644341 1.026587e-02 2.942045e-02 15 64691589 64691591 3 - 2.361 2.294 -0.222
ENSG00000180304 E018 15.5654003 0.0131021221 8.610293e-01 9.143721e-01 15 64691592 64693074 1483 - 1.157 1.144 -0.046
ENSG00000180304 E019 3.0956476 0.0111164511 6.389473e-01 7.524642e-01 15 64693075 64693181 107 - 0.624 0.553 -0.317
ENSG00000180304 E020 18.2339512 0.0014356789 1.212141e-01 2.216629e-01 15 64693182 64695963 2782 - 1.306 1.179 -0.449
ENSG00000180304 E021 3.2536659 0.0690777352 9.364928e-01 9.640693e-01 15 64695964 64696050 87 - 0.565 0.559 -0.029
ENSG00000180304 E022 3.3903335 0.0047200951 2.038505e-01 3.310179e-01 15 64696051 64696303 253 - 0.722 0.529 -0.844
ENSG00000180304 E023 0.8836053 0.0183671663 5.263873e-01 6.596232e-01 15 64700485 64700590 106 - 0.316 0.203 -0.842
ENSG00000180304 E024 551.0541513 0.0002384320 1.549247e-10 2.647007e-09 15 64703029 64703281 253 - 2.749 2.645 -0.344