ENSG00000180198

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373831 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding protein_coding 246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 21.02927 32.82293 19.259854 1.5226781 0.3503273 -0.7687979 0.08408333 0.09883333 0.08860000 -0.01023333 4.103157e-01 1.473203e-27 FALSE TRUE
ENST00000373832 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding protein_coding 246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 46.78099 62.89595 38.359796 1.7032633 1.3903204 -0.7132254 0.19001667 0.19010000 0.17630000 -0.01380000 7.240117e-01 1.473203e-27 FALSE TRUE
ENST00000411533 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding protein_coding 246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 22.42673 27.60392 22.543028 3.8142760 1.4417779 -0.2920745 0.09156667 0.08346667 0.10350000 0.02003333 5.388886e-01 1.473203e-27 FALSE TRUE
ENST00000478232 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding retained_intron 246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 15.87744 29.50826 5.179476 5.0093293 1.3008398 -2.5079471 0.06091250 0.08846667 0.02376667 -0.06470000 1.305681e-03 1.473203e-27 FALSE TRUE
MSTRG.692.11 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding   246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 24.92867 13.70910 36.641231 1.3274190 0.8492497 1.4176761 0.10946667 0.04163333 0.16846667 0.12683333 9.930618e-17 1.473203e-27 FALSE TRUE
MSTRG.692.14 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding   246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 15.64078 10.21066 23.779761 0.8856215 1.1380870 1.2188522 0.06790833 0.03100000 0.10930000 0.07830000 6.217624e-13 1.473203e-27 TRUE TRUE
MSTRG.692.24 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding   246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 58.17079 103.48599 24.151148 8.1894312 0.3612005 -2.0988140 0.22419583 0.31063333 0.11110000 -0.19953333 1.473203e-27 1.473203e-27 FALSE TRUE
MSTRG.692.25 ENSG00000180198 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC1 protein_coding   246.6336 332.1131 217.4761 11.11065 2.409014 -0.6107948 29.51968 40.08579 34.038824 0.9209479 1.0904393 -0.2358457 0.12025833 0.12080000 0.15666667 0.03586667 5.801629e-03 1.473203e-27 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.